Results 31 to 40 of about 1,347,109 (294)

Comparative Analysis of Romanian and Swiss Bovine Populations Using Whole Genome Sequencing and SNP Microarrays

Scientific Papers Animal Science and Biotechnologies, 2023
The use of SNP microarrays has gained distinguished attention in recent years and the identification of numerous SNPs has proven valuable for genetic evaluation and selection in farm animals.
Alexandru Eugeniu Mizeranschi, Radu Ionel Neamț, Ciprian Valentin Mihali, Vlad Goilean, Mihai Carabaș, Daniela Elena Ilie   +5 more
doaj  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

PacBio Single-Molecule Long-Read Sequencing Provides New Light on the Complexity of Full-Length Transcripts in Cattle

Frontiers in Genetics, 2021
Cattle (Bos taurus) is one of the most widely distributed livestock species in the world, and provides us with high-quality milk and meat which have a huge impact on the quality of human life.
Tianpeng Chang, Bingxing An, Mang Liang, Xinghai Duan, Lili Du, Wentao Cai, Bo Zhu, Xue Gao, Yan Chen, Lingyang Xu, Lupei Zhang, Huijiang Gao, Junya Li   +12 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

A draft genome of Drung cattle reveals clues to its chromosomal fusion and environmental adaptation

Communications Biology, 2022
Integrated genomic, transcriptomic, and methylomic data from the endangered Drung cattle (Bos frontalis) provide further insight into its unique physiology and adaptation to alpine environments.
Yan Chen, Tianliu Zhang, Ming Xian, Rui Zhang, Weifei Yang, Baqi Su, Guoqiang Yang, Limin Sun, Wenkun Xu, Shangzhong Xu, Huijiang Gao, Lingyang Xu, Xue Gao, Junya Li   +13 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Genomic Prediction Using LD-Based Haplotypes Inferred From High-Density Chip and Imputed Sequence Variants in Chinese Simmental Beef Cattle

Frontiers in Genetics, 2021
A haplotype is defined as a combination of alleles at adjacent loci belonging to the same chromosome that can be transmitted as a unit. In this study, we used both the Illumina BovineHD chip (HD chip) and imputed whole-genome sequence (WGS) data to ...
Hongwei Li, Bo Zhu, Bo Zhu, Ling Xu, Zezhao Wang, Lei Xu, Peinuo Zhou, Han Gao, Peng Guo, Yan Chen, Xue Gao, Lupei Zhang, Huijiang Gao, Huijiang Gao, Wentao Cai, Lingyang Xu, Junya Li, Junya Li   +17 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Evaluation of Passive Immunity Induced by Immunisation Using Two Inactivated gE-deleted Marker Vaccines against Infectious Bovine Rhinotracheitis (IBR) in Calves

Vaccines, 2020
Different types of vaccines against Infectious Bovine Rhinotracheitis (IBR) are commercially available. Among these, inactivated glycoprotein E (gE)-deleted marker vaccines are commonly used, but their ability to induce passive immunity is poorly known ...
Stefano Petrini, Cecilia Righi, Carmen Iscaro, Giulio Viola, Paola Gobbi, Eleonora Scoccia, Elisabetta Rossi, Claudia Pellegrini, Gian Mario De Mia   +8 more
doaj   +1 more source

Relationship between the structure and composition of rumen microorganisms and the digestibility of neutral detergent fibre in goats [PDF]

Asian-Australasian Journal of Animal Sciences, 2019
Objective This experiment was conducted to compare the structure and composition of ruminal microorganisms in goats with high and low neutral detergent fibre (NDF) digestibility.
Kaizhen Liu, Lizhi Wang, Tianhai Yan, Zhisheng Wang, Bai Xue, Quanhui Peng   +5 more
doaj   +1 more source