Results 131 to 140 of about 545,043 (221)
AABP Conference (2012): Receptions
Description of the 45th American Association of Bovine Practitioners Conference ...
Bovine Practitioners, American Association of
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Structural Proteins of Bovine Coronavirus and Their Intracellular Processing
The Quebec isolate of bovine coronavirus (BCV) was found to contain four unique major structural proteins. These proteins consisted of the peplomeric protein (gp190/E2, gp100/E2), the nucleocapsid protein (p53/N) and its apparent trimer (p160/N), a family of small matrix glycoproteins (gp26/E1, gp25/E1 and p23/E1) and the putative haemagglutinin (gp124/
D, Deregt, M, Sabara, L A, Babiuk
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Searching for Novel COVID19 Treatments: Towards Covalent TMPRSS2 Inhibitors
We designed, synthesised, and evaluated new guanidine derivatives as potential covalent inhibitors of TMPRSS2, a key protease for SARS‐CoV‐2 entry. Computational studies showed that some compounds have improved binding over nafamostat. However, experimentally none effectively blocked viral entry in cell assays, indicating further optimisation is needed.
Marco Minneci +6 more
wiley +1 more source
1991 24th Annual Convention. Orlando, Florida, September 18-21
Description of the 24th Convention of the American Association of Bovine Practitioners ...
Bovine Practitioners, American Association of
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Temporal regulation of bovine coronavirus RNA synthesis
The structure and synthesis of bovine coronavirus (BCV)-specific intracellular RNA were studied. A genome-size RNA and seven subgenomic RNAs with molecular weights of approximately 3.3 X 10(6), 3.1 X 10(6), 2.6 X 10(6), 1.1 X 10(6), 1.0 X 10(6), 0.8 X 10(6) and 0.6 X 10(6) were detected.
Keck, James G. +3 more
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Abstract BACKGROUND Late‐onset Alzheimer's disease (AD) exhibits substantial biological heterogeneity. We developed a framework linking cell‐type–specific polygenic risk profiles to precision medicine in AD. METHODS Cell‐based polygenic risk scores (cbPRSs) derived from single‐nucleus RNA‐seq co‐expression networks were evaluated in Alzheimer's Disease
Nathan Sahelijo +16 more
wiley +1 more source
Bovine Coronavirus Infections in Transported Commingled Beef Calves and Sole-source Ranch Cattle
Bovine respiratory diseases (BRD) occurring in the feedlot represent the major disease entity during the feeding period. Several bacteria, viruses, and Mycoplasma spp are reported as causative agents.
Wahrmund, Jackie +10 more
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A human coronavirus responsible for the common cold massively kills dendritic cells but not monocytes [PDF]
Copyright @ 2012, American Society for Microbiology.Human coronaviruses are associated with upper respiratory tract infections that occasionally spread to the lungs and other organs.
Lorin, V +18 more
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Sigma‐1 Receptor‐Targeting Compounds Show Antiviral Activity Across Multiple Coronavirus Models
ABSTRACT Over the past two decades, coronaviruses have caused three major public health crises, including the epidemics of SARS‐CoV, MERS‐CoV, and SARS‐CoV‐2. Following the outbreak of SARS‐CoV‐2, several antiviral drugs have been approved for the treatment of COVID‐19.
Cuiling Zhang +9 more
wiley +1 more source
Plaque Assay for Titration of Bovine Enteric Coronavirus
The plaquing ability of two isolates of bovine enteric coronavirus (BECV) was studied in HRT18 (human rectal adenocarcinoma) cell monolayers. Both isolates were able to induce plaque formation within 2 to 3 days; plaques appeared as round opalescent areas which remained colourless after neutral red or crystal violet staining.
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