Results 51 to 60 of about 62,638 (248)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Functional interactions of the Tax and p13 proteins of Human T-cell Leukemia Virus Type I [PDF]

, 2013
Human T-cell leukemia virus type 1 (HTLV-1) establishes a lifelong persistent infection in humans. Approximately 3% of the infected individuals will develop adult T-cell leukemia/lymphoma (ATLL), an aggressive malignancy of mature CD4+ T-cells. The viral
Manicone, Mariangela
core  

Bovine Leukemia Virus Involvement In Enzootic Bovine Leukosis

, 1978
Publisher Summary Enzootic bovine leukosis is a contagious disease induced by bovine leukemia virus (BLV). It is a chronic disease that develops over a long period and can be schematically divided into three phases: (1) from birth to infection (some animals are already infected at birth), (2) from viral infection to tumorous transformation (a number ...
Burny, Arsène, Bex, Françoise, Chantrenne, Hubert, Cleuter, Yvette, Dekegel, Daniel, Ghysdael, Jacques, Kettmann, Richard, Leclercq, M, Leunen, Joseph, Mammerickx, Marc, Portetelle, Daniel   +10 more
openaire   +3 more sources

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

ДИАГНОСТИЧЕСКАЯ ОЦЕНКА СЕРОЛОГИЧЕСКОГО И МОЛЕКУЛЯРНОГЕНЕТИЧЕСКОГО МЕТОДОВ ЛАБОРАТОРНЫХ ИССЛЕДОВАНИЙ НА РЕТРОВИРУСНЫЕ ИНФЕКЦИИ КРУПНОГО РОГАТОГО СКОТА

Ветеринарная патология, 2013
It is established that the infection rate of bovine immunodeficiency virus and bovine leukemia virus in farms of the Saratov region is rather high (68.7% and 65,2%, respectively), the combined infection by both retroviruses is registered in 52,5% of ...

doaj  

MODERN METHODS AND EXPERIENCE OF STRUGGLE AGAINST LEUKEMIA OF CATTLE

В мире научных открытий, 2018
The article presents the main methods of diagnosis and control of the bovine leukemia virus currently used. The wide spread of the disease is due to a fairly easy transmission of the virus, the lack of early diagnosis, vaccination and treatment ...
Tatyana Vladimirovna Zubova, Vladimir Alexandrovich Pleshkov, Alexander Nikolaevich Mironov   +2 more
doaj   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Генетическое разнообразие вируса лейкоза крупного рогатого скота и его распространение в районах Республики Дагестан

Юг России: экология, развитие
To study the spread of infection caused by the bovine leukemia virus in farms of the Republic of Dagestan.PCR diagnostics of 212 cattle blood samples collected in farms of the Kizlyarsky, Kumtorkalinsky and Tabasaransky districts was performed for the ...
D. A. Baboshko, M. G. Daudova, P. Y. Achigecheva, K. A. Elfimov, D. K. Dandamaev, Z. R. Shakhbanova, A. V. Totmenin, N. M. Gashnikova   +7 more
doaj   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

The theoretical and practical aspects of the recombinant antigens for the diagnosis of bovine leukemia production

Annals of Mechnikov's Institute, 2020
Introduction. Nowadays the problem of bovine leukemia (EBL) effective diagnosis in countries where EBL is registered and the disease-free areas remains actual.
O Shapovalova
doaj