Results 51 to 60 of about 618,341 (263)

Human milk protein production in xenografts of genetically engineered bovine mammary epithelial stem cells. [PDF]

PLoS ONE, 2010
BACKGROUND: In the bovine species milk production is well known to correlate with mammary tissue mass. However, most advances in optimizing milk production relied on improvements of breeding and husbandry practices.
Eugenio Martignani, Peter Eirew, Paolo Accornero, Connie J Eaves, Mario Baratta   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Comparative inactivation of Listeria monocytogenes in human and bovine milk treated with high-pressure processing and UV-C treatment and potential growth during refrigerated shelf-life

Frontiers in Microbiology
Human and bovine milk differ in composition, including the concentration of antimicrobial components, which may impact the efficacy of non-thermal processes to inactivate foodborne pathogens and may also impact the growth of pathogens introduced via post-
Hussein M. H. Mohamed, Ningjian Liang, Ningjian Liang, Austin Lowder, David C. Dallas, David C. Dallas, Joy Waite-Cusic   +6 more
doaj   +1 more source

Optimised Method for Short-Chain Fatty Acid Profiling of Bovine Milk and Serum

Molecules, 2022
Short-chain fatty acids (SCFA, C2-C5) in milk and serum are derived from rumen bacterial fermentation and, thus, have the potential to be used as biomarkers for the health status of dairy cows.
Cheng Li, Zhiqian Liu, Carolyn Bath, Leah Marett, Jennie Pryce, Simone Rochfort   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

American Association of Bovine Practitioners 36th Annual Conference (2003): Part 1

, 2003
Description and highlights of the 36th Annual Convention American Association of Bovine Practitioners (2003), information about, events, awards, receptions ...
Bovine Practitioners, American Association of
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

AABP Conference (2016): Minutes of the American Association of Bovine Practitioners Annual Business Luncheon

, 2017
Description of the 2016 American Association of Bovine ...
Bovine Practitioners, American Association of
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Aldolase in Bovine Milk

Journal of Dairy Science, 1950
Summary With the procedure of Sibley and Lehninger, the enzyme aldolase has been found in normal cow's milk in the same concentration range as in blood serum. The presence of the enzyme in various milk fractions is indicated, and factors affecting the stability of the enzyme in milk are discussed.
B.D. Polis, H.W. Shmukler
openaire   +1 more source