Results 101 to 110 of about 243,194 (292)

High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering

Advanced Materials, EarlyView.
A high‐throughput in vivo mRNA LNP screening platform is developed and employed to screen a large library of 122 mRNA LNPs in vivo for delivery to immune, stromal, and parenchymal cells, identifying promising LNP candidates. A novel small particle flow cytometry‐based protein adsorption analysis method is utilized to interrogate protein corona ...
Alex G. Hamilton, Ajay S. Thatte, Junchao Xu, Zhangyi Luo, Hannah C. Safford, Kelsey L. Swingle, Jenna Muscat‐Rivera, Michael Kegel, Xuexiang Han, Ryann A. Joseph, Amanda M. Murray, Hannah C. Geisler, Ricardo C. Whitaker, Lulu Xue, Roman Spektor, Jilian R. Melamed, Drew Weissman, Michael J. Mitchell   +17 more
wiley   +1 more source

IL-1R and inflammasomes mediate early pulmonary protective mechanisms in respiratory brucella abortus infection [PDF]

, 2016
Brucella spp. infection is frequently acquired through contaminated aerosols. The role of interleukin-1 beta (IL-1β) in the early pulmonary response to respiratory Brucella infection is unknown.
Alonso Paiva, Iván Mathias, Baldi, Pablo Cesar, Campos, Priscila C., Falivene, Juliana, Fernandez, Andrea Giselle, Ferrero, Mariana Cristina, Hielpos, María Soledad, Muñoz González, Florencia, Oliveira, Sergio Costa, Vieira, Angelica T.   +9 more
core   +1 more source

Matrix Stiffness Governs Fibroblasts’ Regulation of Gingival Immune Homeostasis

Advanced Materials, EarlyView.
This study identifies a “mechano‐epigenetic” checkpoint in which matrix stiffness governs the immune responses of gingival fibroblasts. Using biomimetic hydrogels and human gingival explants, the studies revealed that restoring extracellular matrix stiffness actively suppresses inflammation via non‐canonical NF‐κB signaling and DNA methylation ...
Hardik Makkar, Nghi Tran, Yu‐Chang Chen, Kang I. Ko, Rebecca G. Wells, Kyle H. Vining   +5 more
wiley   +1 more source

Differential expression of microRNAs in bovine papillomavirus type 1 transformed equine cells [PDF]

, 2016
Bovine papillomavirus (BPV) types 1 and 2 play an important role in the pathogenesis of equine sarcoids (ES), the most common cutaneous tumour affecting horses.
Britton, C., Nasir, L., Nicolson, L., Terron-Canedo, N., Weir, W.   +4 more
core   +1 more source

CD207‐Positive Dendritic Cells Promote Emphysema Through CD8+ T Cell Pathway in Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
CD207+ dendritic cells (DCs) drive emphysema by promoting CD8⁺ T cell cytotoxicity via Birbeck granule‐dependent MHC‐I antigen presentation. This DC subset is expanded by cigarette smoke‐induced oxidative stress, which triggers granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) release from airway epithelium.
Shurui Xuan, Yunhui Wu, Feng Liu, Heng Fu, Yaqi Meng, Yingwei Ou, Xijing Yuan, Ian M. Adcock, Man Jia, Xiaoning Zeng, Xin Yao   +10 more
wiley   +1 more source

Bovine Parainfluenza Virus 3 and Bovine Respiratory Syncytial Virus: Dominant Viral Players in Bovine Respiratory Disease Complex among Serbian Cattle

Animals
Bovine respiratory disease complex, a complex respiratory ailment in cattle, results from a combination of viral and bacterial factors, compounded by environmental stressors such as overcrowding, transportation, and adverse weather conditions. Its impact
Vesna Milićević, Sofija Šolaja, Dimitrije Glišić, Milan Ninković, Bojan Milovanović, Milan Đorđević, Snežana Ristevski, Filip Spasojević, Miroljub Dačić   +8 more
doaj   +1 more source

TRIM47 Regulates Energy Metabolism via Glycolytic Reprogramming to Drive Hepatocellular Carcinoma Progression and Represents an Efficient Therapeutic Target

Advanced Science, EarlyView.
This study identifies TRIM47 as a key driver of liver cancer progression by promoting glycolysis through ubiquitin‐mediated degradation of the gluconeogenic enzyme FBP1. TRIM47 enhances glucose uptake, lactate and ATP production, and tumor growth and metastasis.
Weijie Sun, Yihang Yuan, Qian Qiu, Kexuan Tan, Xutong Li, Haotian Li, Luyang Kang, Yuting Gu, Ziheng Zhang, Jiayu He, Jiali Li, Junjie Lin, Zihan Xie, Kexing Han, Jiabin Li, Yang Zhang, Ting Wu, Yufeng Gao   +17 more
wiley   +1 more source

Microbiological Profile of the Upper and Lower Respiratory Tract of Suckling and Weaned Dairy Calves with Acute Respiratory Disease

Veterinary Sciences
Bovine respiratory disease (BRD) is a significant global health issue in cattle farming, leading to substantial economic losses. This study analyzed the microbiological profiles of BRD outbreaks in nine dairy cattle herds in southern Brazil.
Alice Fernandes Alfieri, Juliana Torres Tomazi Fritzen, Carolina Yuka Yasumitsu, Amauri Alcindo Alfieri   +3 more
doaj   +1 more source

Demonstration of early functional compromise of bone marrow derived hematopoietic progenitor cells during bovine neonatal pancytopenia through in vitro culture of bone marrow biopsies [PDF]

, 2012
Background Bovine neonatal pancytopenia (BNP) is a syndrome characterised by thrombocytopenia associated with marked bone marrow destruction in calves, widely reported since 2007 in several European countries and since 2011 in New Zealand. The disease is
Ballingall, Keith T, Bell, Charlotte, Connelly, Maira, Dagleish, Mark P, Laming, Eleanor, Melzi, Eleonora, Rocchi, Mara S, Scholes, Sandra F E, Willoughby, Kim   +8 more
core   +2 more sources

Disengaging the Engine: Histone Deacetylases 1 and 2‐Mediated Acetylation of Hexokinase‐2 Regulates Energy Metabolism in Microglia Following Intracerebral Hemorrhage

Advanced Science, EarlyView.
This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang, Heng Yang, Xinjie Gao, Zengyu Zhang, Ruiyuan Weng, Yuchao Fei, Jiabin Su, Hanqiang Jiang, Wei Ni, Yuxiang Gu   +9 more
wiley   +1 more source