Results 111 to 120 of about 5,713,232 (301)

Microbiological Profile of the Upper and Lower Respiratory Tract of Suckling and Weaned Dairy Calves with Acute Respiratory Disease

Veterinary Sciences
Bovine respiratory disease (BRD) is a significant global health issue in cattle farming, leading to substantial economic losses. This study analyzed the microbiological profiles of BRD outbreaks in nine dairy cattle herds in southern Brazil.
Alice Fernandes Alfieri, Juliana Torres Tomazi Fritzen, Carolina Yuka Yasumitsu, Amauri Alcindo Alfieri   +3 more
doaj   +1 more source

Ancillary Therapy For Bovine Respiratory Disease

, 1993
Through ancillary therapy we attempt to improve response to antimicrobial drugs. Ameliorating the harmful effects of inflammation, blocking the activity of histamine, and improving immune function serve to alter the pathophysiology of the infectious ...
Apley, Michael D.
core  

Monitoring systems for identifying bovine respiratory disease

, 2015
Accurate diagnosis of bovine respiratory disease (BRD) is a critical component of applying appropriate therapy at the optimal time. Visual observation is the conventional manner for BRD diagnosis; however, this method has been shown to have relatively ...
White, Brad
core   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

A survey of herd-level risk factors for bovine respiratory disease (BRD) in nursing beef calves

, 2012
Surveys by the USDA confirm that bovine respiratory disease (BRD) is the leading cause of death of nursing (preweaned) beef calves three weeks of age and older. Management modifications decrease BRD in some cattle populations; however, management-related
Waggoner, E. R., Matlik, D. K., Jones, A. L., Mason, G. L., Woolums, A. R., Engelken, T. J., Irsik, M., Smith, L. J., Smith, D. R., Berghaus, R. D., White, B. J., Ellis, R. W.   +11 more
core   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Associations between Weather Conditions and Bovine Respiratory Disease in Feedlot Cattle

, 2011
Bovine respiratory disease complex (BRD) is the most common cause of disease in weaned cattle. Ambient environmental conditions affect nutritional requirements, metabolism, and BRD risk; however, data on associations between specific weather conditions ...
Fox, J. T., Renter, D. G., Cernicchiaro, N., Babcock, A. H., White, B. J.   +4 more
core   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Efficacy of intranasal vaccines containing bovine corona virus or bovine respiratory syncytial virus and parainfluenza virus type 3 in young calves with or without maternally derived antibodies

Veterinary Vaccine
Bovine respiratory syncytial virus, bovine parainfluenza type 3 virus, and bovine corona virus cause respiratory disease in calves during the first weeks of life and protection should be achieved as young as possible to cover the period with the highest ...
Piet Nuijten, Birgit Makoschey, Elias Salem, Mark van Rooij, Geert Vertenten   +4 more
doaj   +1 more source