Results 101 to 110 of about 138,768 (302)

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Microbiological Profile of the Upper and Lower Respiratory Tract of Suckling and Weaned Dairy Calves with Acute Respiratory Disease

Veterinary Sciences
Bovine respiratory disease (BRD) is a significant global health issue in cattle farming, leading to substantial economic losses. This study analyzed the microbiological profiles of BRD outbreaks in nine dairy cattle herds in southern Brazil.
Alice Fernandes Alfieri, Juliana Torres Tomazi Fritzen, Carolina Yuka Yasumitsu, Amauri Alcindo Alfieri   +3 more
doaj   +1 more source

The Effect of Market Forces on Bovine Respiratory Disease

Veterinary Clinics of North America: Food Animal Practice, 2020
Bovine respiratory disease (BRD) is a persistent negative economic impact on beef and dairy industries and the inability to show any progress in controlling BRD is a source of increasing frustration among animal health professionals and the industry.
openaire   +2 more sources

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

An investigation of the association between herpesviruses and respiratory disease in racehorses in Western Australia

, 2003
Respiratory disease is an important cause of wastage in the Australian horse racing industry and viruses are frequently suspected as aetiological agents of respiratory disease or poor performance by clinicians and trainers but confirmation is seldom ...
Wang, Liping
core  

Bovine Respiratory Disease (BRD) Risk Assessment Tool [PDF]

, 2020
The Bovine Respiratory Disease (BRD) risk assessment tool for preweaned calves on dairies relies on scores that are proportional to the association measures observed between management risk factors and BRD.
Karle, Betsy, Williams, Deniece, Love, William, Maier, Gabriele, Champagne, John, Anderson, Randall, Dubrovsky, Sasha, Rowe, Joan, Lehenbauer, Terry, Van Eenennaam, Alison, Aly, Sharif   +10 more
core  

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Efficacy of intranasal vaccines containing bovine corona virus or bovine respiratory syncytial virus and parainfluenza virus type 3 in young calves with or without maternally derived antibodies

Veterinary Vaccine
Bovine respiratory syncytial virus, bovine parainfluenza type 3 virus, and bovine corona virus cause respiratory disease in calves during the first weeks of life and protection should be achieved as young as possible to cover the period with the highest ...
Piet Nuijten, Birgit Makoschey, Elias Salem, Mark van Rooij, Geert Vertenten   +4 more
doaj   +1 more source

Bovine Respiratory Disease virtual symposium [PDF]

Animal Health Research Reviews, 2020
Christopher C L, Chase, Amelia R, Woolums   +1 more
openaire   +2 more sources

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source