Results 141 to 150 of about 242,788 (314)

Immobilisation of free-ranging Galapagos sea lions [PDF]

, 1979
Trillmich, F., Wiesner, Henning
core   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

An assessment of opportunities to dissect host genetic variation in resistance to infectious diseases in livestock [PDF]

, 2009
Adzhubei, Ait-Ali, Al-Haddawi, Asif, Atapattu, Bacon, Bacon, Bakker, Barillet, Barrow, Barrow, Bishop, Boyd, Briles, Brisbin, Bumstead, Bumstead, Bumstead, Bumstead, Bumstead, Callaway, Cao, Carlén, Caverly, Cheng, Chiodini, Cole, Cutlip, Dassanayake, Davies, Diez-Tascon, Dileepan, Dominik, E. Giuffra, Ewart, Flori, Fragkou, Friars, G. Davies, Gasbarre, Gauly, Gavora, Gibbons, Gonda, Gonda, Gordon, Gougoulis, Guy, Gyles, Haesebrouck, Hala, Halbur, Hassan, Hayes, Heringstad, Hickford, Houston, Hu, Jackwood, Jensen, Jiao, Juul-Madsen, Kaiser, Kaufman, Keane, Khatkar, Koets, Kramer, Lamont, Lavi, Legarra, Lewis, Liu, Liu, Longenecker, Lund, Lundeheim, Lundeheim, MacKinnon, Mackintosh, Malek, Mariani, Martin, Mavrogianni, Mays, Meijerink, Minion, Mirsky, Moen, Mortensen, Muggli-Cockett, Nakajima, Nieuwhof, Niewold, Noormohammadi, Opriessnig, Peng, Permin, Perry, Petry, Petry, Pinard-van der Laan, Pinard-van der Laan, Purchase, Python, Raadsma, Reiner, Rise, Roehrig, Ruiz, Rupp, S. Genini, S.C. Bishop, Sacco, Schmidt, Schou, Sellwood, Smith, Snowder, Snowder, Sonstegard, Tilquin, Tsai, Tuggle, Uthe, Uthe, Vallejo, Van Diemen, Van Dorp, Van Hemert, Van Hemert, Van Reeth, Vincent, Vincent, Von Schalburg, Vögeli, Wang, Wetten, Williams, Williams, Witter, Yonash, Yonash, Yoo, Young, Yunis, Zhang, Zhu   +147 more
core   +1 more source

Mitochondrial dysfunction promoted by Porphyromonas gingivalis lipopolysaccharide as a possible link between cardiovascular disease and periodontitis [PDF]

, 2011
Oxidative stress is one of the factors that could explain the pathophysiological mechanism of inflammatory conditions that occur in cardiovascular disease (CVD) and periodontitis.
Battino, Maurizio, Bullon, Pedro, Cordero Morales, Mario David, Morillo, J.M., Quiles, José L., Ramirez Tortosa, Maria Carmen   +5 more
core  

Transdermal Delivery of an mRNA‐Liposome Vaccine via Dissolving Microneedle to Preserve Vaccine Activity and Enhance Immune Activation

Advanced Science, EarlyView.
An mRNA‐liposome vaccine via dissolving microneedles (ML‐DMN) enables efficient skin‐targeted delivery while preserving mRNA integrity and allowing sustained antigen expression. Unlike intramuscular (IM) injection, ML‐DMN engages skin‐resident immune cells, activates antigen‐presenting cells (APCs), and induces strong T cell and cytokine responses at ...
Jeehye Nam, JiWon Ahn, Jiwoo Shin, Nahong Lee, Youjin Lee, Sung min Cho, Paul Kim, Geonwoo Kang, Sang‐Jun Ha, Hyungil Jung   +9 more
wiley   +1 more source

Mass‐Produced and High‐Performance Nanowell Biosensor Fabricated via Semiconductor Manufacturing for Rapid and Accurate COVID‐19 Diagnosis in the Clinical Field

Advanced Science, EarlyView.
A semiconductor‐fabricated nanowell biosensor enables rapid, scalable, and highly reproducible detection of SARS‐CoV‐2 antigens from nasal swabs within ∼10 minutes. Clinical validation in 249 retrospective and 243 prospective patient samples demonstrates high sensitivity and specificity, minimal cross‐reactivity, and robust batch‐to‐batch ...
Yoo Min Park, Zahra Rezaei, Nam Ho Bae, Donggee Rho, Da‐Seul Kim, EunYoung Go, YoungTae Seo, Seok Jae Lee, Won Chan Seo, Luke P. Lee, HeaYeon Lee, Su Ryon Shin   +11 more
wiley   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Mitochondrial Enzymes Mimetic Ultrasmall Palladium Nanozymes Prevent Senescence and Neurodegeneration Through Metabolic Reprogramming

Advanced Science, EarlyView.
Simply constructed polyvinylpyrrolidone (PVP) modified palladium nanoparticles (PdP NPs) as cytochrome c oxidase (CcO) and superoxide dismutase (SOD) mimic are promising multifunctional nanoreactors to boost mitochondrial respiration chain function and refine homeostasis via regulation of mitochondrial dynamics and proteostasis sensor UPRmt, which ...
Wenshu Cong, Haiming Jing, Zinan Li, Wenjing Zhang, Nan Zhang, Yingqiu Xie, Shan Gao, Yuanyu Huang, Junyu Ning   +8 more
wiley   +1 more source

Clinical perspectives of emerging pathogens in bleeding disorders. [PDF]

, 2006
As a result of immunological and nucleic-acid screening of plasma donations for transfusion-transmissible viruses, and the incorporation of viral reduction processes during plasma fractionation, coagulation-factor concentrates (CFC) are now judged safe ...
Bozzette, Samuel, Diamond, Michael, Koerper, Marion A, Kulkarni, Roshni, Ludlam, Christopher A, Powderly, William G, Ritchie, Bruce, Siegel, Jamie, Simmonds, Peter, Stanley, Samuel, Tapper, Michael L, von Depka, Mario   +11 more
core   +1 more source

Copper Depletion Nanoparticles Potentiate Cancer Immunotherapy by Avoiding Innate and Adaptive Immune Resistance

Advanced Science, EarlyView.
A mitochondria‐targeted copper depletion nanoplatform (CYN‐CDA@Alb) was developed to selectively disrupt tumor mitochondria copper, which then reprogrammed the tumor immune microenvironment by depressing PD‐L1 and CD47 expression simultaneously. By doing this, CYN‐CDA@Alb reversed radiotherapy‐induced immune tolerance, showing the potential usage of ...
Zaigang Zhou, Ke Li, Xuelan Li, Lei Yi, Zhengxiang Wang, Huan Ding, Sheng Wu, Feiyu Liu, Yuan Li, Rui Cheng, Jianliang Shen   +10 more
wiley   +1 more source