Results 41 to 50 of about 142,549 (217)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Bovine respiratory disease associated with Histophilus somni and bovine respiratory syncytial virus in a beef cattle feedlot from Southeastern Brazil

Semina: Ciências Agrárias, 2017
Bovine respiratory disease (BRD) is a complex multifactorial and multi-etiological disease entity that is responsible for the morbidity and mortality particularly in feedlot cattle from North America.
Selwyn Arligton Headley, Luciana Carvalho Balbo, Alice Fernandes Alfieri, João Paulo Elsen Saut, Anderson Lopes Baptista, Amauri Alfieri   +5 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Association of herd BRSV and BHV-1 seroprevalence with respiratory disease and reproductive performance in adult dairy cattle

Acta Veterinaria Scandinavica, 2012
Background The aim of this study was to detect the associations between bovine herpesvirus 1 (BHV-1) status of a herd and respiratory disease (BRD) occurrence and reproductive performance in pregnant heifers and cows.
Raaperi Kerli, Bougeard Stephanie, Aleksejev Annely, Orro Toomas, Viltrop Arvo   +4 more
doaj   +1 more source

Phylogenetic analysis of bovine respiratory syncytial virus from calves with respiratory disorders [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2018
Bovine respiratory disease (BRD) causes economic losses related to a reduction in weight gain of affected animals, veterinary treatment costs, death, etc.
İlke KARAYEL HACIOĞLU, Nüvit COŞKUN, Selda DURAN YELKEN, Seçil SEVİNÇ, Feray ALKAN   +4 more
doaj   +1 more source

The Cell-Mediated Immune Response against Bovine alphaherpesvirus 1 (BoHV-1) Infection and Vaccination

Vaccines, 2023
Bovine Alphaherpesvirus 1 (BoHV-1) is one of the major respiratory pathogens in cattle worldwide. Infection often leads to a compromised host immune response that contributes to the development of the polymicrobial disease known as “bovine respiratory ...
Cecilia Righi, Giulia Franzoni, Francesco Feliziani, Clinton Jones, Stefano Petrini   +4 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Detection and molecular characterization of bovine enterovirus E2 from dairy calves with respiratory disease in Urumqi, Xinjiang, China

Frontiers in Cellular and Infection Microbiology
IntroductionBovine enterovirus (BEV) is a contagious viral agent that can cause respiratory infections and disease outbreaks among calves. This study reports an outbreak that occurred in a population of dairy calves in northern Xinjiang in November 2024 ...
Xintong Chen, Juanjuan Pan, Yangyuhua Wang, Yangyuhua Wang, Yong Wei, Yong Wei, Xiuyu Zhang, Haichun Jiang, Haichun Jiang, Lei Zhang, Lei Zhang, Guiling Wu, Guiling Wu, Baoyu Chen, Baoyu Chen, Jinxin Xie, Jinxin Xie, Panpan Tong   +17 more
doaj   +1 more source

Development of a nanoparticle-assisted PCR assay for detection of bovine respiratory syncytial virus

BMC Veterinary Research, 2019
Background Bovine respiratory syncytial virus (BRSV) is a common pathogen causing respiratory disease in cattle and a significant contributor to the bovine respiratory disease (BRD) complex.
Zhankui Liu, Jianyou Li, Zeyu Liu, Jiawei Li, Zhijie Li, Chao Wang, Jianke Wang, Li Guo   +7 more
doaj   +1 more source