Results 251 to 260 of about 721,610 (311)

Silencing Myostatin Using In Vivo Self‐Assembled siRNA Protects Against Cancer‐ and Dexamethasone‐Induced Muscle Atrophy

open access: yesAdvanced Healthcare Materials, EarlyView.
This study reports an in vivo self‐assembled siRNA strategy that enables the liver to generate small extracellular vesicles (sEVs) tagged with a muscle‐targeting peptide (MSP) and naturally loaded with myostatin (MSTN)‐siRNA. These MSP‐tagged sEVs are systemically delivered to skeletal muscle, efficiently silence MSTN, promote muscle hypertrophy, and ...
Xin Yin   +14 more
wiley   +1 more source

Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery

open access: yesAdvanced Healthcare Materials, EarlyView.
This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo   +3 more
wiley   +1 more source

ROS‐Triggered Microgels for Programmable Drug Release in Volumetric Muscle Loss Repair

open access: yesAdvanced Healthcare Materials, EarlyView.
Reduced graphene oxide‐incorporated hyaluronic acid microgels are developed as ROS‐responsive, injectable platforms for curcumin delivery in volumetric muscle loss. The microgels exhibit strong antioxidative activity, high drug‐loading capacity, and ROS‐triggered release.
Seungjun Lee   +5 more
wiley   +1 more source

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