Results 61 to 70 of about 7,416 (159)
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang +23 more
wiley +1 more source
Abstract This case report describes pituitary abscess syndrome (PAS) in a 20‐month‐old Blonde d'Aquitaine heifer with cranial nerve deficits (V, VII, VIII, IX, X and XII) associated with facial hemiparesis, head tilt, ataxia and dysphagia, pneumonia and otitis interna.
Chloé Saada +4 more
wiley +1 more source
Harvest increase and culling as tools for managing chronic wasting disease in white‐tailed deer
We used an agent‐based model to simulate the effect of CWD management on a white‐tailed deer population in northwest Indiana and northeast Illinois. Our results suggest that wildlife managers should reconsider how and if they should manage CWD. Abstract Chronic wasting disease (CWD), a transmissible spongiform encephalopathy that affects white‐tailed ...
Jonathan D. Brooks +3 more
wiley +1 more source
Accumulation of L-type Bovine Prions in Peripheral Nerve Tissues
We recently reported the intraspecies transmission of L-type atypical bovine spongiform encephalopathy (BSE). To clarify the peripheral pathogenesis of L-type BSE, we studied prion distribution in nerve and lymphoid tissues obtained from experimentally ...
Yoshifumi Iwamaru +16 more
doaj +1 more source
Abstract Pastoral practices remain a widespread economic activity across European mountain regions. However, the viability of this activity may be threatened by the recovery of large wild vertebrates associated with passive rewilding, leading to the so‐called human–wildlife conflicts.
P. Acebes +4 more
wiley +1 more source
Review on prion diseases in animals with emphasis to Bovine Spongiform Encephalopathy
Prion diseases are known as Transmissible Spongiform Encephalopathies (TSE). These are degenerative brain disorders characterized by tiny microscopic holes that give the brain 'spongy' appearance.
Rajender P. Gupta +3 more
doaj
From Meat to Plant‐Based Products? The Enduring Impact of BSE on Beef Consumption
ABSTRACT This study reassesses the impact of the historical BSE outbreak on EU diets, showing that consumption patterns shifted persistently even after policy actions eliminated the food safety risk. Utilizing advanced difference‐in‐differences techniques on 1980–2020 data, we demonstrate that while beef consumption exhibited a transient U‐shaped ...
Jader Velásquez, Shon Ferguson
wiley +1 more source
Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga +11 more
wiley +1 more source
Differentiation of Prions from L-type BSE versus Sporadic Creutzfeldt-Jakob Disease
We compared transmission characteristics for prions from L-type bovine spongiform encephalopathy and MM2-cortical sporadic Creutzfeldt-Jakob disease in the Syrian golden hamster and an ovine prion protein–transgenic mouse line and isolated distinct prion
Simon Nicot +5 more
doaj +1 more source
ABSTRACT This article analyses the recent expansion of Argentina's beef exports in the context of China's emergence as the world's leading beef importer and the principal destination for Argentine exports. It examines shifts in production, export orientation and domestic consumption, and analyses the export‐oriented fractions of meat capital that have ...
Emilia Ormaechea +2 more
wiley +1 more source

