Results 151 to 160 of about 814,199 (298)

Bovine tuberculosis

open access: yes
Bovine tuberculosis (TB), caused by Mycobacterium bovis, poses significant challenges to both human and animal health worldwide. This article examines various aspects of bovine TB, including its etiology, clinical symptoms in humans and animals, laboratory diagnosis, and vaccination strategies.
openaire   +2 more sources

Characterization of DnaB–DnaG Interaction in M. tuberculosis Using Small‐Angle X‐ray Scattering‐Based Dissociation Assay

open access: yesChemBioChem, Volume 26, Issue 14, July 18, 2025.
The study characterizes interactions between DnaB helicase and DnaG primase in Mycobacterium tuberculosis using small‐angle X‐ray scattering, surface plasmon resonance, and cross‐linking. The findings reveal that DnaG forms dimers in solution, which are destabilized upon DnaB binding.
Dayan A, Ilic S, Akabayov B
wiley   +1 more source

Harnessing Organometallic Au(III) Complexes as Precision Scaffolds for Next‐Generation Therapeutic and Imaging Agents

open access: yesChemBioChem, Volume 26, Issue 14, July 18, 2025.
Cyclometalated gold(III) complexes offer a versatile platform for selective biological interactions, including cysteine arylation, redox modulation, and enzyme inhibition. This review explores their roles in anticancer, antimicrobial, and protein modification strategies, highlighting their ability to disrupt metabolic pathways, modulate aquaporins, and
Sophie R. Thomas, Riccardo Bonsignore
wiley   +1 more source

Synthesis, Antimycobacterial Activity, and Computational Insight of Novel 1,4‐Benzoxazin‐2‐one Derivatives as Promising Candidates against Multidrug‐Resistant Mycobacterium Tuberculosis

open access: yesChemMedChem, Volume 20, Issue 14, July 18, 2025.
A series of 14 novel 1,4‐benzoxazinone derivatives is tested against various strains of Mycobacterium tuberculosis. All compounds show high activity against all tested strains, particularly the resistant strains. Additionally, the novel derivatives exhibit low cytotoxicity toward mammalian Vero cells.
Maria Grazia Mamolo   +6 more
wiley   +1 more source

The Regulatory Mechanisms of Treponema pallidum Enolase on Macrophages: From Enzymatic Activity to Signal Transduction

open access: yesThe FASEB Journal, Volume 39, Issue 13, 15 July 2025.
ABSTRACT Syphilis, caused by the gram‐negative bacterium Treponema pallidum, remains a significant global public health threat. Despite the efficacy of antibiotic treatment in controlling syphilis, the pathogenic mechanisms of T. pallidum, particularly its interactions with the host immune system, are not well understood.
Peiyuan Sun   +12 more
wiley   +1 more source

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