Results 71 to 80 of about 1,649,716 (257)

Critical Roles of O‐Acetylation Revealed by Synthetic Trisaccharide Antigens for a Broad‐Spectrum Anti‐Salmonella Vaccine

Advanced Science, EarlyView.
A synthetic glycoconjugate vaccine based on a diacetylated Salmonella trisaccharide elicits broadly protective antibodies against four major human pathogenic serovars. Mechanistic studies identify 2,3‐di‐O‐acetylation of rhamnose as a critical determinant of antigen recognition and breadth of protection, establishing a new strategy for broad‐spectrum ...
Xingling Pan, Soham Maity, Herbert Kavunja, Yuvarani Murali, Ting‐An Chen, Chang‐xin Huo, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +1 more source

Specific Inhibition of Bovine Viral Diarrhea Virus Replicase [PDF]

Journal of Virology, 2003
ABSTRACT Compound-1453 was identified and characterized as a specific inhibitor of bovine viral diarrhea virus (BVDV). The concentration of compound-1453 which results in 50% protection from virus-induced cytopathic effect is ∼2.2 μM, with a therapeutic index of 60, and it is not active against a panel of RNA and DNA viruses.
Jin-Hua, Sun, Julie A, Lemm, Donald R, O'Boyle, Jason, Racela, Richard, Colonno, Min, Gao   +5 more
openaire   +2 more sources

Comparing Cytopathic and Noncytopathic Bovine Viral Diarrhea Virus (BVDV) Vaccines: Antigen Trafficking Increased to Mucosal Surfaces with Noncytopathic Vaccines

, 2008
Bovine viral diarrhea virus (BVDV) is a major pathogen of cattle causing severe respiratory and reproductive disease. Since BVDV infects through the oral-nasal route, increasing mucosal immunity should decrease BVDV infection and disease.
Holler, L., Braun, L. J., Spire, M., Chase, C. C. L.   +3 more
core   +1 more source

SAT1‐Induced Spermidine Depletion Potentiates Food Allergy

Advanced Science, EarlyView.
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Manman Liu, Beiyu Zhang, Junjuan Wang, Yue Jiang, Shiwen Han, Qianwei Wang, Lingyu Zeng, Jinfeng Wang, Huilian Che   +8 more
wiley   +1 more source

Isolation of Bovine Viral Diarrhea Virus from an Alpaca [PDF]

Journal of Veterinary Diagnostic Investigation, 2002
A frozen, stillborn alpaca ( Lama pacos) was submitted to the Minnesota Veterinary Diagnostic Laboratory for diagnostic purposes. No gross or histopathologic changes of any significance were seen. A pool of lung, liver, and brain tissues was positive for bovine viral diarrhea virus (BVDV) by reverse transcription–polymerase chain reaction.
Sagar M, Goyal, Mostafa, Bouljihad, Sigrun, Haugerud, Julia F, Ridpath   +3 more
openaire   +2 more sources

Inhibition of Bovine Herpesvirus 1 and Bovine Viral Diarrhea Virus Replication by Genistein: a Compound in Soybeans

, 2001
Bovine herpesvirus type 1 (BHV-1, IBR), an alphaherpesvirus, and bovine viral diarrhea virus (BVDV), a pestivirus, are important cattle pathogens. Genistein, a naturally occurring flavonoid in soybeans, inhibits in vitro replication of herpes simplex ...
Peterson, D., Wang, C. Y., Braun, L. J., El-Sheikh, A. A., Chase, C. C. L., Shaw, A.   +5 more
core   +1 more source

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

Advanced Science, EarlyView.
DUET‐seq is an open‐source droplet platform that jointly profiles chromatin accessibility and gene expression from the same nucleus. Dissolvable dual‐linker hydrogel beads and a one‐step intra‐droplet RT‐PCR co‐index both modalities in under 12 h at roughly $0.04 per cell.
Dong Cheng, Zijun Meng, Lan Wei, Pingjing Yang, Fanfan Zhang, Zhiyi Luo, Ting Lai, Chunli Li, Mengyao Zhao, Mengqin Xu, Jiaqi Wang, Linjun Li, Huarong Chen, Jin Li, Ailong Huang, Youquan Bu, Liuyang Zhao   +16 more
wiley   +1 more source

Identifying Fetal Bovine Viral Diarrhea Virus Infection from Amniotic and Allantoic Fluid

, 2002
Control of Bovine Viral Diarrhea Virus (BVDV) relies on accurate identification of persistently infected (PI) animals. A persistent infection can develop when a fetus is exposed to virus in utero, prior to 125 days gestation.
Tan, Lucy, Callan, Robert J., Van Campen, Hana   +2 more
core   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Effects of Testing and Removal of Persistently Infected Bovine Viral Diarrhea Virus Feeder Calves on Morbidity and Mortality of Home Pen-associated Feeder Calves

, 2006
Crossbred feeder calves (2,868 head 20 lots) were tested for bovine viral diarrhea virus persistent infection(BVD PI). The effects of testing and removal of persistently infected bovine viral diarrhea virus feeder calves on morbidity and mortality of ...
Lindberg, N. N., Thomson, D. U., Stevens, E. T.   +2 more
core   +1 more source