Results 91 to 100 of about 116,603 (307)

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Shock formation around planets orbiting M-dwarf stars

, 2011
Bow shocks can be formed around planets due to their interaction with the coronal medium of the host stars. The net velocity of the particles impacting on the planet determines the orientation of the shock. At the Earth's orbit, the (mainly radial) solar
Fossati, Fossati, Hebb, Kasting, Lai, Llama, Parker, Schlaufman, Vidotto, Vidotto, Vidotto   +10 more
core   +2 more sources

Temporal Interference Stimulation Enhances Neural Regeneration

Advanced Science, EarlyView.
Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressott, Maria Garcia Garrido, Patrycja Dzialecka, Rachel Man Hoi Law, Roberto Portillo‐Lara, Bethany Geary, Elena Faillace, Shirine Merlo‐Nikpay Aslie, Marcelina Wojewska, Maria Otero‐Jimenez, Martina Genta, Luqiao Tan, Karen Duff, Javier Alegre‐Abarrategui, Rylie Green, Nir Grossmann   +15 more
wiley   +1 more source

The Milky Way Project MOBStIRS: Parameterizing Infrared Stellar-wind Bow Shock Morphologies with Citizen Science

The Astronomical Journal
Mass-loss influences stellar evolution, especially for massive stars with strong winds. Stellar wind bow shock nebulae driven by Galactic OB stars can be used to measure mass-loss rates ( $\dot{M}$ ).
Angelica S. Whisnant, Matthew S. Povich, Nikhil Patten, Henry A. Kobulnicky   +3 more
doaj   +1 more source

Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy

Advanced Science, EarlyView.
Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao, Zihan Deng, Yufei Liu, Li Liu, Deqiang Deng, Muyang Yang, Yuanyuan Geng, Yao Sun, Beilei Yue, Jonathan F. Lovell, Yushuai Liu, Lisen Lu, Honglin Jin   +12 more
wiley   +1 more source

Variability in Saturn's bow shock and magnetopause from pioneer and voyager: Probabilistic predictions and initial observations by Cassini [PDF]

, 2005
Probability distributions for the location of the Saturnian bow shock and magnetopause have been derived by extrapolating observations of dynamic solar wind pressures to the position of Saturn's orbit. These observations are those made by the Pioneer 11,
Achilleos, N, Dougherty, MK, Hendricks, S, Neubauer, FM, Russell, CT   +4 more
core  

The Cone-Like H-alpha Nebula in NGC 4945: A Galactic Superwind Bow Shock ?

, 1997
We find that a non-axisymmetric bow shock model, with an appropriate choice of parameters, could fit the line splitting velocity field of the cone-like H$\alpha$ nebula in NGC 4945 better than a canonical cone model.
Bandiera R., Cozial R., Huang R. Q., Jie-Hao Huang, Moorwood A. F. M., Nakai N., Schneps M. H., Yang Chen, Ye T.-S., Yorke H. W.   +9 more
core   +2 more sources

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Cometary shaped sources at the Galactic Center - Evidence for a wind from the central 0.2 pc [PDF]

, 2010
In 2007 we reported two cometary shaped sources in the vicinity of Sgr A* (0.8" and 3.4" projected distance), named X7 and X3. The symmetry axes of the two sources are aligned to within 5 degrees in the plane of the sky and the tips of their bow-shocks ...
A. Eckart, Acker, Baganoff, Beloborodov, Benedettini, Blandford, Blöcker, Bouret, Bower, Brandner, Comerón, Eckart, Eckart, Eckart, Eisenhauer, Figer, Figer, G. Witzel, Ghez, Ghez, Gillessen, K. Mužić, Laor, Lu, Lutz, M. Zamaninasab, Mac Low, Marrone, Mathis, Muzic, Muzic, Najarro, Nisini, Paumard, Paumard, Portegies Zwart, Povich, R. Buchholz, R. Schödel, Raga, Schödel, Schödel, Schödel, Tanner, Van Buren, Villaver, Yuan, Yusef-Zadeh, Yusef-Zadeh, Yusef-Zadeh, Zhang, Zhao   +51 more
core   +1 more source

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source