Results 91 to 100 of about 505,915 (296)
Advanced Science, EarlyView.PTBP1‐mediated alternative splicing drives a pathogenic switch to the DNAJB6b isoform in everolimus‐resistant clear cell renal cell carcinoma. This splicing event programs a positive feedback loop including EIF4B/PKIB/AKT/mTOR, promoting aggressive therapy resistance.
Xiu‐wu Pan +18 more
wiley +1 more source
Simulation of a perpendicular bow shock
Geophysical Research Letters, 1981 Simulations of a high Mach number shock with parameters typical of the earth's bow shock have been performed using a hybrid (particle ions, fluid electrons) code. The simulations reproduce the observed ion reflection and overshoots in the magnetic field and density. These features are shown to be closely associated with ion gyration.
M. M. Leroy +4 more
openaire +1 more source
Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism
Advanced Science, EarlyView.Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He +7 more
wiley +1 more source
Probing the Low-velocity Regime of Nonradiative Shocks with Neutron Star Bow Shocks
The Astrophysical Journal LettersNonradiative shocks accelerate particles and heat astrophysical plasmas. While supernova remnants are the most well-studied example, neutron star (NS) bow shocks are also nonradiative and Balmer dominated.
Stella Koch Ocker, Maren Cosens
doaj +1 more source
Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition
Advanced Science, EarlyView.CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu +13 more
wiley +1 more source
Advanced Science, EarlyView.AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang +19 more
wiley +1 more source
Advanced Science, EarlyView.Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang +11 more
wiley +1 more source
Efficient computation of ultraviolet radiation from bow shock waves
, 2014 Ultraviolet(UV)emissions radiated by nitric oxide(NO)and hydroxyl radical(OH)in the bow shock experiment[1]are computed using the direct simulation Monte Carlo(DSMC)method and the Navier–Stokes equations,respectively.Compared to previous studies[2,3],the
万田, 张羽淮, 樊菁, 蒋建政
core +2 more sources
Fundamental Parameters for Central Stars of 103 Infrared Bow Shock Nebulae
The Astrophysical JournalStellar bow shock nebulae are arcuate shock fronts formed by the interaction of radiation-driven stellar winds and the relative motion of the ambient interstellar material.
Nikhil Patten +18 more
doaj +1 more source