Results 71 to 80 of about 505,915 (296)
A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints
ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu +3 more
wiley +1 more source
Mesoporous mixed ionic‐electronic PU/PEDOT: PSS electrodes enable label‐free detection of stochastic extracellular bioelectrical dynamics in living Phaeodactylum tricornutum. Living diatoms actively modulate interfacial ionic dynamics, establishing stochastic electrochemical noise as a sensitive probe of microbial bioelectrochemical activity and a new ...
David M. S. Silva +7 more
wiley +1 more source
Numerical Simulation of the Effect of Swing Center on a Supersonic Split Line Nozzle
A numerical investigation was performed in the present work to uncover the effect of swing center on a supersonic split line nozzle. Detailed nozzle internal flow and thrust performance were analysed, for serval swing center positions.
Shuhui ZHAO +5 more
doaj +1 more source
Statistical survey of day-side magnetospheric current flow using Cluster observations: bow shock [PDF]
We present the first comprehensive statistical survey of the day-side terrestrial bow shock current system based on a large number of Cluster spacecraft bow shock crossings.
E. Liebert, C. Nabert, K.-H. Glassmeier
doaj +1 more source
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan +16 more
wiley +1 more source
The free escape continuum of diffuse ions upstream of the Earth's quasi-parallel bow shock [PDF]
The Earth's bow shock is very efficient in accelerating ions out of the incident solar wind distribution to high energies (≈ 200 keV/e). Fluxes of energetic ions accelerated at the quasi-parallel bow shock, also known as diffuse ions, are best ...
Janzen, P. +29 more
core +2 more sources
In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang +8 more
wiley +1 more source
Mercury’s Bow Shock and Magnetopause Variations According to MESSENGER Data
Using data from the MESSENGER spacecraft magnetometer that describes the magnetopause and the bow shock crossing points of the Mercury’s magnetosphere, we have calculated the parameters of the paraboloids of revolution approximating the obtained points ...
Dmitry Nevsky +2 more
doaj +1 more source

