Results 51 to 60 of about 116,603 (307)

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Interplanetary shock transmitted into the Earth's magnetosheath: Cluster and Double Star observations [PDF]

Annales Geophysicae, 2010
On day 7 May 2005, the plasma instruments on board Double Star TC1 and Cluster SC3 spacecraft register inside the magnetosheath, at 19:15:12 and 19:16:20 UT, respectively, a strong pressure pulse due to the impact of an interplanetary shock wave (IS ...
G. Pallocchia, A. A. Samsonov, M. B. Bavassano Cattaneo, M. F. Marcucci, H. Rème, C. M. Carr, J. B. Cao   +6 more
doaj   +1 more source

Radio light curves during the passage of cloud G2 near Sgr A* [PDF]

, 2013
We calculate radio light curves produced by the bow shock that is likely to form in front of the G2 cloud when it penetrates the accretion disk of Sgr A*.
Abarca, D., Guo, X., Narayan, R., Ozel, F., Sadowski, A., Sironi, L.   +5 more
core   +1 more source

Entropy Generation across Earth’s Collisionless Bow Shock

Physical Review Letters, 2012
Earth's bow shock is a collisionless shock wave but entropy has never been directly measured across it. The plasma experiments on Cluster and Double Star measure 3D plasma distributions upstream and downstream of the bow shock allowing calculation of Boltzmann's entropy function H and his famous H theorem, dH/dt≤0.
Parks, G. K., Lee, E., Mccarthy, M., Goldstein, M. L., Fu, S. Y., Cao, J.B., Canu, Patrick, Lin, N., Wilber, M., Dandouras, I., Rème, H., Fazakerley, A.   +11 more
openaire   +5 more sources

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

The Large Magellanic Cloud’s ∼30 kpc Bow Shock and Its Impact on the Circumgalactic Medium

The Astrophysical Journal Letters, 2023
The interaction between the supersonic motion of the Large Magellanic Cloud (LMC) and the circumgalactic medium (CGM) is expected to result in a bow shock that leads the LMC’s gaseous disk.
David J. Setton, Gurtina Besla, Ekta Patel, Cameron Hummels, Yong Zheng, Evan Schneider, Munier Salem   +6 more
doaj   +1 more source

Using numerical models of bow shocks to investigate the circumstellar medium of massive stars

, 2014
Many massive stars travel through the interstellar medium at supersonic speeds. As a result they form bow shocks at the interface between the stellar wind.
Cox, Nick, Decin, Leen, Meliani, Zakaria, van Marle, Allard Jan   +3 more
core   +3 more sources

LMC X-1: A New Spectral Analysis of the O-star in the binary and surrounding nebula [PDF]

, 2017
We provide new observations of the LMC X-1 O star and its extended nebula structure using spectroscopic data from VLT/UVES as well as H$\alpha$ imaging from the Wide Field Imager on the Max Planck Gesellschaft / European Southern Observatory 2.2m ...
Filipovic, Miroslav D., Grieve, Kevin, Hyde, Elaina A., Kaper, Lex, O'Brien, Andrew N., Ritter, Andreas, Russell, David M.   +6 more
core   +2 more sources

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Large scale simulations of the jet-IGM interaction [PDF]

, 2003
In a parameter study extending to jet densities of $10^{-5}$ times the ambient one, I have recently shown that light large scale jets start their lives in a spherical bow shock phase.
Krause, Martin G. H.
core   +6 more sources