Results 21 to 30 of about 7,817 (97)

Advanced Experiment Design Strategies for Drug Development

Advanced Intelligent Discovery, Volume 2, Issue 4, August 2026.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang, Anthony Harker, Mohan Edirisinghe, Maryam Parhizkar   +3 more
wiley   +1 more source

Dynamic, Unconstrained Optimization of Secreted Enzyme Production in Fed‐Batch Fermentation Using Reinforcement Learning

Biotechnology and Bioengineering, Volume 123, Issue 8, Page 2024-2036, August 2026.
ABSTRACT Reinforcement learning (RL) has been used to control a wide range of dynamic processes, especially ones that are too complex to model well or have stochastic environmental perturbations. Fed‐batch fermentations are subject to changes in starting cell growth rates and process variations that can affect cell growth and secreted target production.
Sai Harish Uthravalli, Sakib Ferdous, J. Michael Hess, Nigel F. Reuel   +3 more
wiley   +1 more source

From Fish Waste to Stable Omega‐3 Bioactive Lipids: Encapsulation Strategies and a Conceptual Framework for Antioxidant and Antimicrobial Functional Food Fortification

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Fish waste is valorized into omega‐3‐rich bioactive lipids (EPA and DHA), followed by stabilization through advanced encapsulation technologies to prevent oxidation and improve storage stability. Encapsulation protects polyunsaturated fatty acids from oxidation, improves storage stability, enables controlled gastrointestinal release, and enhances ...
Abebe Desalegn, Habtamu Admassu, Gadissa Mosisa, Gebeyehu Ayele, Molla Abeje, Tanaji Kudre   +5 more
wiley   +1 more source

Development of Functional Bread Fortified with Hawthorn Leaf Phenolic Extract: Evaluation of Technological Performance and Phenolic Bioaccessibility

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
This study investigates the production of hawthorn (Crataegus azarolus) leaf extract–fortified functional bread. Ultrasound‐assisted extraction was optimized using Response Surface Methodology (Box–Behnken design) by adjusting extraction time, temperature, and ethanol concentration.
Semra Topuz Türker, Esra Esin, Mustafa Bayram, Cemal Kaya   +3 more
wiley   +1 more source

Comparative Phytochemical Profiles and Antioxidant Potential of Green and Variegated Morphotypes of Alternanthera bettzickiana Under Optimized Extraction Conditions

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Green and variegated Alternanthera bettzickiana morphotypes were compared after optimizing extraction (Box–Behnken design–RSM: 90% ethanol, 50°C, 2 h, 10 mg/mL). The green morphotype had higher phenolic content, FRAP, and ORAC activity, while the variegated morphotype had higher flavonoid and anthocyanin content.
Sirinapa Thangsiri, Woorawee Inthachat, Piya Temviriyanukul, Amornrat Aursalung, Yuraporn Sahasakul, Uthaiwan Suttisansanee   +5 more
wiley   +1 more source

Encapsulation of Nigella sativa Essential Oil by Complex Coacervation Using Gelatin and Gum Arabic

Journal of Food Science, Volume 91, Issue 8, August 2026.
ABSTRACT This study aimed to encapsulate Nigella sativa essential oil (NSEO) using gelatin (Ge) and gum arabic (GA) via complex coacervation to produce NSEO microcapsules (NSEO‐MCs), optimize encapsulation conditions, characterize the microcapsules, and evaluate antimicrobial activity.
Neslihan Mutlu, Ümmü Gülsüm Koç
wiley   +1 more source

Tunable Natural Deep Eutectic Solvents‐Driven Fractionation of Olive Pomace in an Integrated Biorefinery: Linking Lignin Structural Tailoring to Carbohydrate Valorization and Biopolymer Production

ChemSusChem, Volume 19, Issue 13, 14 July 2026.
Microwave‐conditioned olive pomace was fractionated with deep eutectic solvents (DESs) spanning acidic, neutral, alkaline, and chemo‐enzymatic regimes. The alkaline DES provided the best balance between delignification and carbohydrate preservation, yielding a fermentable glucose/xylose stream suitable for Haloferax mediterranei fermentation and poly(3‐
Ivelina Ivaylova Dzhambazova, Maria Laura Alfieri, Lucia Panzella, Ozge Sakyan Demirkol, Fabio De Stefano, Cinzia Pezzella, Simona Varriale   +6 more
wiley   +1 more source

Defining an operational selectivity window for rare-earth flotation using a Box-Behnken design. [PDF]

Sci Rep
Choi J, Hong G, Kim W.
europepmc   +1 more source

Optimization of Falcon concentrator for iron recovery from blast furnace sludge using Box-Behnken design. [PDF]

Sci Rep
Çerik Ç.
europepmc   +1 more source

Optimizations of Calcium-Reinforced Nanophytosome of Pomegranate Extract Using Box-Behnken Design. [PDF]

Food Sci Nutr
Sedighi R, Rajabzadeh G, Rafe A.
europepmc   +1 more source