Results 21 to 30 of about 12,165 (138)

Optimization of paclitaxel loaded poly (ε-caprolactone) nanoparticles using Box Behnken design

Beni-Suef University Journal of Basic and Applied Sciences, 2017
Optimization is a critical process in the development of nanoparticles to apprehend the formulation variables and quality attributes. The purpose of this study was to evaluate the influence of formulation variables viz., drug/polymer ratio (A ...
Nandhakumar Sathyamoorthy, Dhanaraju Magharla, Pavankumar Chintamaneni, Sundar Vankayalu   +3 more
doaj   +1 more source

USE OF BOX–BEHNKEN DESIGN FOR OPTIMIZATION OF COMPOUNDED MEDICATION: ACYCLOVIR CAPSULES REPORT

Drug Analytical Research, 2021
Campus compounding pharmacies play an important role in public health. Herpes simplex is one of the most common viral diseases in humans, which generates a great demand for acyclovir capsules in compounding pharmacy. It is well known that the formulation'
Suelen da Silva Reis, Valdemir da Silva Quintanilha Junior, Gabriella da Silva Boto, Thalita Martins da Silva, Elizabeth Valverde Macedo, Carlos Augusto de Freitas Peregrino , Samanta Cardozo Mourão, Emeli Moura de Araújo   +7 more
doaj   +5 more sources

Bridging Virtual and Reality: Testing Design of Experiment Procedures with Simulated and Experimental Data

Engineering Proceedings, 2023
A virtual experiment conducted using the ICP-MS TuneSim software served as the basis for studies that compared the applicability of the central composite design with the Box–Behnken design in analytical chemistry applications.
Agnieszka Królicka, Anna Szczurkowska
doaj   +1 more source

Optimization And Characterization of Silver Nanoparticle Biosynthesis Using Parijoto Fruit (Medinilla speciosa) Water Extract With Box-Behnken Design

Journal of Food and Pharmaceutical Sciences
Silver nanoparticles in the medical field are used as additives in vaccines, anti-diabetic agents, wound and bone healing, biosensors and anticancer therapy in medical applications.
Qinta Laily Nurjana, Azizah Amin, Viviane Annisa, Siti Zahliyatul Munawiroh   +3 more
doaj   +1 more source

Optimization of the experimental parameters of fluticasone propionate microparticles for pulmonary delivery using a box behenken design

Journal of Pharmacy and Bioallied Sciences, 2012
The objective of this study was to examine extensively the influences of formulation and process variables on the microparticles. The microparticles were generated by the spray-drying technique using polymer chitosan, mannitol along with L-leucine.
P V Patel, T G Soni, V T Thakkar, T R Gandhi   +3 more
doaj   +1 more source

Optimization Studies on Imatinib Mesylate Loaded Nanoliposomes Using Box-Behnken Design

Nano Biomedicine and Engineering, 2022
Nanoliposomes are bilayer phospholipid vesicles used to encapsulate and deliver therapeutic agents. The study was aimed to investigate the effects of critical variables on nanoliposomes characteristics.
Mandeep Dahiya, Rajendra Awasthi, Gaurav Gupta, Sachin Kumar Singh, Monica Gulati, Niraj Kumar Jha, Saurabh Kumar Jha, Ankur Sharma, Parteek Prasher, Krishnan Anand, Dinesh Kumar Chellappan, Kamal Dua, Harish Dureja   +12 more
doaj   +1 more source

Advanced Experiment Design Strategies for Drug Development

Advanced Intelligent Discovery, EarlyView.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang, Anthony Harker, Mohan Edirisinghe, Maryam Parhizkar   +3 more
wiley   +1 more source

Rheological and Mechanical Analyses of Felbinac Cataplasms by Using Box–Behnken Design

Pharmaceutics, 2018
Felbinac, an active pharmaceutical ingredient (API) used clinically for the treatment of osteoarthritis, has poor solubility. Felbinac cataplasm product design was investigated using rheological and mechanical analyses.
Jie Yang, Yishen Zhu, Yongqin Diao, Caiyun Yin   +3 more
doaj   +1 more source

Autonomous AI‐Driven Design for Skin Product Formulations

Advanced Intelligent Discovery, EarlyView.
This review presents a comprehensive closed‐loop framework for autonomous skin product formulation design. By integrating artificial intelligence‐driven experiment selection with automated multi‐tiered assays, the approach shifts development from trial‐and‐error to intelligent optimisation.
Yu Zhang, Yongrui Xiao, Chunlin Chen, Dimitrios Tsaoulidis, Kai Yang, Tao Chen   +5 more
wiley   +1 more source

Quality-by-design based fabrication of febuxostat-loaded nanoemulsion: Statistical optimization, characterizations, permeability, and bioavailability studies

Heliyon, 2023
The present work deals with QbD-based development of FEB-loaded nanoemulsion (FEB-NE) in order to enhance bioavailability and permeability. In the beginning, the risk assessment was performed on different experimental variables using the Ishikawa diagram
Vishal C. Gurumukhi, Vivek P. Sonawane, Ganesh G. Tapadiya, Sanjaykumar B. Bari, Sanjay J. Surana, Shailesh S. Chalikwar   +5 more
doaj   +1 more source