Results 61 to 70 of about 153,301 (238)

Partial regularity of Leray-Hopf weak solutions to the incompressible Navier-Stokes equations with hyperdissipation

, 2021
We show that if $u$ is a Leray-Hopf weak solution to the incompressible Navier--Stokes equations with hyperdissipation $\alpha \in (1,5/4)$ then there exists a set $S\subset \mathbb{R}^3$ such that $u$ remains bounded outside of $S$ at each blow-up time,
Ożański, Wojciech S.
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The Application of Computed Tomography to Study the Soil Porosity of Mountain Red Earth

Applied Sciences
Mountain red soil, as a special type of soil in the South, has received widespread attention for its soil erosion problems. Its pore structure restricts water infiltration, thereby affecting the occurrence and development of soil erosion.
Hongchen Ye, Zongheng Xu, Linglong Zha, Yunying Chen   +3 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Statistics and geometry of cosmic voids

, 2009
We introduce new statistical methods for the study of cosmic voids, focusing on the statistics of largest size voids. We distinguish three different types of distributions of voids, namely, Poisson-like, lognormal-like and Pareto-like distributions.
A. Gabrielli, A.V. Tikhonov, A.Z. Mekjian, B.B. Mandelbrot, B.J. Jones, C.M. Bender, D. Sornette, D.S. Mitrinovic, G. Kauffmann, H. El-Ad, J. Betancort-Rijo, J. Einasto, J. Gaite, J. Gaite, J. Gaite, J.M. Colberg ., José Gaite, K. Falconer, M. Vergassola, P. Coles, P.J.E. Peebles, P.J.E. Peebles, S. Borgani, S. Colombi, S.D.M. White, S.N. Gurbatov, V. Icke, W. Franz   +27 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Exploring self-similarity of complex cellular networks: The edge-covering method with simulated annealing and log-periodic sampling

, 2006
Song, Havlin and Makse (2005) have recently used a version of the box-counting method, called the node-covering method, to quantify the self-similar properties of 43 cellular networks: the minimal number $N_V$ of boxes of size $\ell$ needed to cover all ...
Albert, Barabási, Basu, Didier Sornette, Dorogovtsev, Feder, Goh, Huang, Jeong, Johansen, Keller, Kim, Kirkpatrick, Mandelbrot, Newman, Newman, Song, Song, Sornette, Sornette, Strogatz, Suchecki, Watts, Wei-Xing Zhou, Yook, Zhi-Qiang Jiang, Zhou, Zhou   +27 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Multifractal behaviour of river networks [PDF]

Hydrology and Earth System Sciences, 2000
A numerical multifractal analysis was performed for five river networks extracted from Calabrian natural basins represented on 1:25000 topographic sheets.
S. G. De Bartolo, S. Gabriele, S. Gabriele, R. Gaudio   +3 more
doaj