Results 11 to 20 of about 12,404 (179)

Preparation, Characterization, and Evaluation of Breviscapine Nanosuspension and Its Freeze-Dried Powder

Pharmaceutics, 2022
As a biopharmaceutics classification system (BCS) class IV drug, breviscapine (Bre) has low solubility in water, poor chemical stability, a short biological half-life and rapid removal from plasma.
Ting Zhang, Xixi Li, Juewen Xu, Jingbao Shao, Meihong Ding, Senlin Shi   +5 more
doaj   +1 more source

NANOSTRUCTURED LIPOSOMES FOR NOSE TO BRAIN DELIVERY OF CARMUSTINE: IN VIVO EVALUATION [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2022
Nano sized particles are promising mediators for the administration of active compounds in the nasal and cerebral systems. However, the ability to achieve relevant therapeutic concentrations of exogenous molecules in the body is dependent mainly on the ...
K.B. Sekhar, M. Alagusundaram, G. Vani
doaj   +1 more source

Penerapan Desain Eksperimen Plackett-Burman dan Box-Behnken pada Analisis Voltametri Pulsa Diferensial untuk Penentuan Kadar Senyawa Kompleks Gd-DTPA

Alchemy, 2020
Gadolinium merupakan salah satu golongan unsur tanah jarang yang menarik karena memiliki sifat paramagnetik yang tinggi. Pengkhelatan gadolinium dengan ligan dietilentriaminpentaasetat (DTPA) menghasilkan senyawa yang berguna dalam bidang kesehatan ...
Santhy Wyantuti, Ravenna Aristantia, Yeni Wahyuni Hartati, Husein H Bahti   +3 more
doaj   +1 more source

A comparison of two hybrid optimization techniques: the Taguchi-BBD-firefly and the Taguchi-regression-firefly methods on the IS 2062-E250 steel plates boring problem

Journal of Engineering and Applied Science, 2023
The expanding proliferation of components for engineering applications requires greater optimisation of parameters, which consequently increases the need for more efficient boring practices.
Ebun Fasina, Babatunde Alade Sawyerr, Yakubu Umar Abdullahi, Sunday Ayoola Oke   +3 more
doaj   +1 more source

Honokiol-Loaded Nanoemulsion for Glioblastoma Treatment: Statistical Optimization, Physicochemical Characterization, and an In Vitro Toxicity Assay

Pharmaceutics, 2023
Background: Glioblastoma (GBM) is an extremely invasive and heterogenous malignant brain tumor. Despite advances in current anticancer therapy, treatment options for glioblastoma remain limited, and tumor recurrence is inevitable.
Aleksandra Gostyńska, Joanna Czerniel, Joanna Kuźmińska, Jakub Brzozowski, Aleksandra Majchrzak-Celińska, Violetta Krajka-Kuźniak, Maciej Stawny   +6 more
doaj   +1 more source

The application of Box-Behnken-Design in the optimization of HPLC separation of fluoroquinolones [PDF]

Scientific Reports, 2019
AbstractBox-Behnken Design is a useful tool for the optimization of the chromatographic analysis. The goal of this study was to select the most significant factors that influenced the following parameters of the chromatographic separation: retention time, relative retention time, symmetry of the peaks, tailing factor, a number of theoretical plates ...
Andrzej Czyrski, Justyna Sznura
openaire   +2 more sources

Study of alcoholic fermentation of an aqueous extract of butiá palm (Butia eriospatha (Martius) Beccari) pulp: Optimization by response surface methodology

Semina: Ciências Exatas e Tecnológicas, 2015
The fermentation conditions were established and an incomplete Box-Behnken factorial design was applied. The independent variables used were yeast extract, yeast and NH4H2PO4, and the alcohol yield obtained was optimized.
Caroline de Souza Cardoso, Kelly Roberta Spacino, Elisângela Tavares da Silva, Cezar Henrique Furtoso Rodrigues, Karina Gomes Angilelli, Ivanira Moreira, Dionisio Borsato   +6 more
doaj   +1 more source

Statistical modeling and optimization of ultrasound-assisted biodiesel production using various experimental designs

Zaštita Materijala, 2019
The present study compares the performances of the regression models developed by the response surface methodology combined with the full factorial, Box-Behnken or face central composite designs applied for the ultrasound-assisted KOH-catalyzed ...
Vlada B. Veljković, Dragana B. Radosavljević, Ivan J. Stojković   +2 more
doaj   +1 more source

QbD assisted development and optimization of composite guar gum silver nanoparticle-based posaconazole hydrogel [PDF]

Nanomedicine Journal
Objective(s): This study aimed to enhance the bioavailability and optimize a composite silver nanoparticle-based Posaconazole hydrogel using a Quality by Design (QbD) approach.
Anushree Piplonia, Upendra Bhadoriya, Nitin Dubey   +2 more
doaj   +1 more source

Evaluating Percentage Rotatability For The Small Box – Behnken Design

Journal of Mathematics and Statistics Studies, 2021
Rotatability property for the Small Box-Behnken design is discussed in this paper. This paper aimed at applying a measure of obtaining percentage rotatability on the Small Box-Behnken designs to determine if the Small Box-behnken designs are rotatable or not and investigated the extent of rotatability in terms of percentage.
Lawrence Chizoba Kiwu, Desmond Chekwube Bartholomew, Fidelia Chinenye Kiwu-Lawrence, Chukwudi Paul Obite, null Okafor Ikechukwu Boniface   +4 more
openaire   +2 more sources