Results 51 to 60 of about 7,613 (182)
A prospective natural history study protocol for clinical trial readiness in synaptic disorders
Epilepsia, EarlyView.Abstract Objective STXBP1‐related disorder (STXBP1‐RD) and SYNGAP1‐related disorder (SYNGAP1‐RD) are two common genetic synaptopathies that are associated with epilepsy, developmental delay, intellectual developmental disorder, and behavioral problems.
Jillian L. McKee +38 more
wiley +1 more source
European Eating Disorders Review, EarlyView.ABSTRACT Background Carers are essential in their young person's recovery during transition from child to adult eating disorder services. Despite recommendations, carer's own needs can be overlooked in transition planning. Subsequently, carers experience distress in supporting their young person and navigating the transition.
Isabel Lenham +13 more
wiley +1 more source
Architecture‐Interface Co‐Design of g‐C3N4 Driven Dry Thick Cathodes Enabling Fast Li‐Ion Transport
Exploration, EarlyView.To break the energy–power trade‐off in dry‐processed thick cathodes, we use g‐C3N4 as a multifunctional additive. In content‐optimized single‐layer electrodes (∼21.5 mg cm−2), transient Li–N coordination lowers Li+ desolvation energy and improves wetting; together, these effects raise 3C capacity by 165.9% and power density by 2.85×.
Hye Ji Eun +12 more
wiley +1 more source
FlexMat, EarlyView.The development of conventional phototheranostic nanomedicines suffers from an intrinsic trade‐off between NIR‐II fluorescence emission and phototherapeutic effects, leading to poor overall efficacy. Herein, we propose an innovative fluorination strategy by constructing fluorinated surroundings in NIR‐II‐emissive organic semiconducting agents to ...
Xiaoming Hu +7 more
wiley +1 more source
Human Resource Management, EarlyView.ABSTRACT This study unravels how the effects of work‐life policies (WLPs) on individual employees' perceived control over their work schedule have cumulative effects across employees, ultimately crossing levels to enhance organizational outcomes like sales.
Margarita Mayo +4 more
wiley +1 more source
iMetaMed, EarlyView.Applying single‐cell RNA‐seq techniques to large‐scale clinical phenotypic data enables the discovery of differential disease progression trajectories and the construction of data‐driven progression scores. These can then be integrated into precision medicine studies to investigate the drivers of patient‐specific disease outcomes. ABSTRACT We propose a
Christian Anderson +11 more
wiley +1 more source
Strategies and mechanisms of precision genome engineering: From gene editing to genome writing
iMetaOmics, EarlyView.In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang +19 more
wiley +1 more source
iMeta, EarlyView.Climate change demands accelerated plant adaptation and de novo domestication. Yet current enviromics focuses disproportionately on external environments, neglecting internal dynamics—gene expression, metabolic flux, and signal transduction—within predictive envirotyping frameworks.
Lin‐An Zhang +8 more
wiley +1 more source
iMeta, EarlyView.From ecological principles to precision engineering of plant microbiomes for sustainable agriculture. The plant holobiont integrates diverse microbial niches (including rhizosphere, endosphere, phyllosphere, seed, and aerial‐root mucilagesphere), host genetics (namely M genes), and host metabolites. Furthermore, molecular dialogues, including rhizobial
Mi Wei +26 more
wiley +1 more source
Journal of the Science of Food and Agriculture, EarlyView.Abstract Mycotoxins remain a persistent threat to the safety and quality of cereal grains and other agricultural products, and their impact on human health continues to raise global concerns. In many situations, the practices traditionally used to control these toxins are no longer sufficiently effective. They can be costly, difficult to implement on a
Abolfazl Asqardokht‐Aliabadi +2 more
wiley +1 more source