Results 21 to 30 of about 63,165 (118)
Journal of Biological Chemistry, 2020 Activation of the immune costimulatory molecule cluster of differentiation 40 (CD40) in Müller glia has been implicated in the initiation of diabetes-induced retinal inflammation.
Sadie K. Dierschke +4 more
semanticscholar +1 more source
CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability
Genes & Development, 2019 Here, Choi et al. show that CDK12, the RNA polymerase II C-terminal domain kinase, which regulates genome stability, expression of DNA repair genes, and cancer cell drug resistance, also phosphorylates the mRNA 5′ cap-binding repressor 4E-BP1 to promote ...
S. Choi +6 more
semanticscholar +1 more source
Liquid–liquid phase separation of H3K27me3 reader BP1 regulates transcriptional repression
Genome BiologyBromo-adjacent homology-plant homeodomain domain containing protein 1 (BP1) is a reader of histone post-translational modifications in fungi. BP1 recognizes trimethylation of lysine 27 in histone H3 (H3K27me3), an epigenetic hallmark of gene silencing ...
G. Tang +6 more
semanticscholar +1 more source
Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours
Nature Communications, 2018 Aberrant expression of long noncoding RNA H19 has been associated with tumour progression, but the underlying molecular tumourigenesis mechanisms remain largely unknown.
Z. Wu +18 more
semanticscholar +1 more source
Communication Subsystems for Emerging Wireless Technologies [PDF]
, 2012 The paper describes a multi-disciplinary design of modern communication systems. The design starts with the analysis of a system in order to define requirements on its individual components.
Gotthans, T. +12 more
core +1 more source
4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer.
Cancer Research, 2019 Aberrant activation of the PI3K-mTOR signaling pathway occurs in >80% of head and neck squamous cell carcinomas (HNSCC), and overreliance on this signaling circuit may in turn represent a cancer-specific vulnerability that can be exploited ...
Zhiyong Wang +19 more
semanticscholar +1 more source
PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment
MedComm, Volume 6, Issue 8, August 2025.The PI3K/AKT/mTOR signaling axis is crucial in cancer progression, regulating cell growth, survival, and metabolism. Often hyperactivated through mutations or loss of tumor suppressors such as PTEN, this pathway promotes cancer cell proliferation and survival by inhibiting apoptosis and activating mTOR, which drives protein synthesis and suppresses ...
Mingyang Jiang +10 more
wiley +1 more source
Issues and Challenges in Cataloguing Arabic Books in Malaysian Academic Libraries [PDF]
, 2011 Education in Library and Information Science is a requirement to become a librarian. There are a lot of syllabuses and subjects to concentrate on such as cataloguing and classification, information retrieval, knowledge management, and reference.
Ismail, Mohd Ikhwan +1 more
core
Acta Physiologica, Volume 241, Issue 8, August 2025.ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth +2 more
wiley +1 more source
Issues and challenges in cataloguing arabic books in Malaysian academic libraries / Mohd Ikhwan Ismail and Nurul Azurah Md. Roni [PDF]
, 2011 Education in Library and Information Science is a requirement to become a librarian. There are a lot of syllabuses and subjects to concentrate on such as cataloguing and classification, information retrieval, knowledge management, and reference.
Ismail, Mohd Ikhwan +1 more
core