Results 31 to 40 of about 63,165 (118)

Caffeine Potentiates Ethanol-Induced Neurotoxicity Through mTOR/p70S6K/4E-BP1 Inhibition in SH-SY5Y Cells

International journal of toxicology, 2020
Caffeine is a popular psychostimulant, which is frequently consumed with ethanol. However, the effects of caffeine on neuronal cells constantly exposed to ethanol have not been investigated.
Pongsak Sangaunchom, P. Dharmasaroja
semanticscholar   +1 more source

Cancer‐Associated Fibroblasts: Heterogeneity, Cancer Pathogenesis, and Therapeutic Targets

MedComm, Volume 6, Issue 7, July 2025.
Cancer‐associated fibroblasts (CAFs) arise from normal fibroblasts in response to various tumor microenvironmental signals, including cytokines such as TGF‐β and IL‐6, paracrine factors like PDGFs, Notch signaling, extracellular vesicles, as well as aging, inflammation, hypoxia, oxidative stress, and increased extracellular matrix (ECM) stiffness. Upon
Yutao Li, Qingyun Liu, Xilin Jing, Yuqi Wang, Xiaohua Jia, Xing Yang, Kezhong Chen   +6 more
wiley   +1 more source

Signal propagation in mobile communication systems [PDF]

, 2013
Tato práce popisuje základní princip funkce mobilních komunikačních systémů. Blíže jsou zde popsány systémy GSM, UMTS. Práce se zabývá zejména problematikou ztrát při šíření signálu, které nastávají mezi vysílačem a přijímačem.
Julínek, Pavel
core  

Daily blood flow restriction does not preserve muscle mass and strength during 2 weeks of bed rest

The Journal of Physiology, Volume 603, Issue 13, Page 3837-3856, 1 July 2025.
Abstract figure legend Two weeks of bed rest lowers skeletal muscle mass and strength. Daily passive blood flow restriction during bed rest does not modulate daily muscle protein synthesis and does not preserve skeletal muscle mass or strength. Created with BioRender.com.
Cas J. Fuchs, Wesley J. H. Hermans, Jean Nyakayiru, Michelle E. G. Weijzen, Joey S. J. Smeets, Thorben Aussieker, Joan M. Senden, Will K. H. W. Wodzig, Tim Snijders, Lex B. Verdijk, Luc J. C. van Loon   +10 more
wiley   +1 more source

Vanillic Acid Suppresses HIF-1α Expression via Inhibition of mTOR/p70S6K/4E-BP1 and Raf/MEK/ERK Pathways in Human Colon Cancer HCT116 Cells

International Journal of Molecular Sciences, 2019
Hypoxia-inducible factor 1 (HIF-1) plays a pivotal role in tumor adaptation to microenvironmental hypoxia, and it also exerts important roles in angiogenesis and tumor development.
Jingli Gong, Shengxue Zhou, Shihai Yang
semanticscholar   +1 more source

ANGPTL4 Induces TMZ Resistance of Glioblastoma by Promoting Cancer Stemness Enrichment via the EGFR/AKT/4E-BP1 Cascade

International Journal of Molecular Sciences, 2019
Glioblastoma (GBM) is the most aggressive type of brain tumor, with strong invasiveness and a high tolerance to chemotherapy. Despite the current standard treatment combining temozolomide (TMZ) and radiotherapy, glioblastoma can be incurable due to drug ...
Y. Tsai, An-Chih Wu, Wen-Bin Yang, T. Kao, J. Chuang, Wen-Chang Chang, T. Hsu   +6 more
semanticscholar   +1 more source

Characteristic, Regulation and Targeting Strategies of Cancer Stem Cells and Their Niche in Digestive System Tumors

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Cancer stem cells, characterized by self‐renewal, differentiation, heterogeneity, plasticity and tumorigenicity, are regulated by intrinsic factors such as signaling pathways, transcription factors, metabolism and noncoding RNAs, as well as environmental cells (including tumor cells, immune cells and stromal cells), environmental factors and distant ...
Zhenzhen Chen, Huanle Qi, Yapeng Xue, Yaqi Zhang, Zhuo Zhang, Shun Xu, Shixin Liao, Xiaoyu Zeng, Jiayi Wu, Xinrui Lv, Qiankun He, Pingping Zhu   +11 more
wiley   +1 more source

The Role of Cholesterol Metabolism and Its Regulation in Tumor Development

Cancer Medicine, Volume 14, Issue 7, April 2025.
ABSTRACT Background Within the tumor microenvironment, tumor cells undergo metabolic reprogramming of cholesterol due to intrinsic cellular alterations and changes in the extracellular milieu. Furthermore, cholesterol reprogramming within this microenvironment influences the immune landscape of tumors, facilitating immune evasion and consequently ...
Yongmei Wu, Wenqian Song, Min Su, Jing He, Rong Hu, Youbo Zhao   +5 more
wiley   +1 more source

Estimating the effect size of the 15Q11.2 BP1–BP2 deletion and its contribution to neurodevelopmental symptoms: recommendations for practice

Journal of Medical Genetics, 2019
Background The 15q11.2 deletion is frequently identified in the neurodevelopmental clinic. Case–control studies have associated the 15q11.2 deletion with neurodevelopmental disorders, and clinical case series have attempted to delineate a microdeletion ...
A. Jønch, E. Douard, C. Moreau, Anke Van Dijck, M. Passeggeri, F. Kooy, J. Puechberty, Carolyn Campbell, D. Sanlaville, Henrietta Lefroy, S. Richetin, A. Pain, D. Geneviève, U. Kini, C. Le Caignec, J. Lespinasse, A. Skytte, B. Isidor, C. Zweier, J. Caberg, M. Delrue, R. Møller, A. Bojesen, H. Hjalgrim, C. Brasch-Andersen, E. Lemyre, L. Ousager, S. Jacquemont   +27 more
semanticscholar   +1 more source

eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer.

JCI Insight, 2019
Pancreatic ductal adenocarcinoma (PDAC) relies on hyperactivated protein synthesis. Consistently, human and mouse PDAC lose expression of the translational repressor and mTOR target 4E-BP1.
D. Müller, Sauyeun Shin, T. Goullet de Rugy, R. Samain, R. Baer, Manon Strehaiano, Laia Masvidal-Sanz, J. Guillermet‐Guibert, C. Jean, Yoshinori Tsukumo, N. Sonenberg, Frédéric Marion, N. Guilbaud, J. Hoffmann, O. Larsson, C. Bousquet, S. Pyronnet, Y. Martineau   +17 more
semanticscholar   +1 more source