Results 41 to 50 of about 63,165 (118)

Cell death pathways: molecular mechanisms and therapeutic targets for cancer

MedComm, Volume 5, Issue 9, September 2024.
This graphical abstract provides a comprehensive view of therapeutic strategies for studying cell death pathways in cancer. Abstract Cell death regulation is essential for tissue homeostasis and its dysregulation often underlies cancer development. Understanding the different pathways of cell death can provide novel therapeutic strategies for battling ...
Shaohui Wang, Sa Guo, Jing Guo, Qinyun Du, Cen Wu, Yeke Wu, Yi Zhang   +6 more
wiley   +1 more source

Parent-of-Origin Effects in 15q11.2 BP1-BP2 Microdeletion (Burnside-Butler) Syndrome

International Journal of Molecular Sciences, 2019
To identify whether parent-of-origin effects (POE) of the 15q11.2 BP1-BP2 microdeletion are associated with differences in clinical features in individuals inheriting the deletion, we collected 71 individuals reported with phenotypic data and known ...
K. W. Davis, Moises A. Serrano, S. Loddo, Catherine Robinson, V. Alesi, B. Dallapiccola, A. Novelli, M. Butler   +7 more
semanticscholar   +1 more source

Renal cancer: signaling pathways and advances in targeted therapies

MedComm, Volume 5, Issue 8, August 2024.
Comprehensive summary of therapeutic strategies and corresponding targets in renal cancer. Abstract Renal cancer is a highlyheterogeneous malignancy characterized by rising global incidence and mortalityrates. The complex interplay and dysregulation of multiple signaling pathways,including von Hippel–Lindau (VHL)/hypoxia‐inducible factor (HIF ...
Aimin Jiang, Jinxin Li, Ziwei He, Ying Liu, Kun Qiao, Yu Fang, Le Qu, Peng Luo, Anqi Lin, Linhui Wang   +9 more
wiley   +1 more source

O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1–dependent mitochondrial dysfunction in the retina

Journal of Biological Chemistry, 2019
Diabetes promotes the posttranslational modification of proteins by O-linked addition of GlcNAc (O-GlcNAcylation) to Ser/Thr residues of proteins and thereby contributes to diabetic complications.
Sadie K. Dierschke, William P. Miller, John S. Favate, Premal Shah, Y. Imamura Kawasawa, Anna C. Salzberg, S. Kimball, L. Jefferson, Michael D. Dennis   +8 more
semanticscholar   +1 more source

Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy

Cancer Communications, Volume 44, Issue 3, Page 297-360, March 2024.
Abstract Cancer is a leading cause of death worldwide. Targeted therapies aimed at key oncogenic driver mutations in combination with chemotherapy and radiotherapy as well as immunotherapy have benefited cancer patients considerably. Tumor protein p53 (TP53), a crucial tumor suppressor gene encoding p53, regulates numerous downstream genes and cellular
Bin Song, Ping Yang, Shuyu Zhang
wiley   +1 more source

Discovering Jewish Studies Collections in Academic Libraries: A Practical Guide

, 2014
The U.S. colleges and universities offering non-sectarian educational programs in Jewish Studies rely on the support of their academic libraries for research materials and library services.
Taler, Izabella
core  

Mitosis-related phosphorylation of the eukaryotic translation suppressor 4E-BP1 and its interaction with eukaryotic translation initiation factor 4E (eIF4E)

Journal of Biological Chemistry, 2019
Eukaryotic translation initiation factor 4E (eIF4E)–binding protein 1 (4E-BP1) inhibits cap-dependent translation in eukaryotes by competing with eIF4G for an interaction with eIF4E.
Rui Sun, Erdong Cheng, C. Velásquez, Yuan Chang, P. Moore   +4 more
semanticscholar   +1 more source

Understanding exosomes: Part 2—Emerging leaders in regenerative medicine

Periodontology 2000, Volume 94, Issue 1, Page 257-414, February 2024.
Abstract Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of diseases ...
Richard J. Miron, Nathan E. Estrin, Anton Sculean, Yufeng Zhang   +3 more
wiley   +1 more source

4E‐BP1 and 4E‐BP2 double knockout mice are protected from aging‐associated sarcopenia

Journal of Cachexia, Sarcopenia and Muscle, 2019
Sarcopenia is the loss of muscle mass/function that occurs during the aging process. The links between mechanistic target of rapamycin (mTOR) activity and muscle development are largely documented, but the role of its downstream targets in the ...
O. Le Bacquer, Kristell Combe, V. Patrac, B. Ingram, L. Combaret, D. Dardevet, C. Montaurier, J. Salles, C. Giraudet, C. Guillet, N. Sonenberg, Y. Boirie, S. Walrand   +12 more
semanticscholar   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source