Results 51 to 60 of about 63,165 (118)

Translational repression of Ccl5 and Cxcl10 by 4E‐BP1 and 4E‐BP2 restrains the ability of mouse macrophages to induce migration of activated T cells

European Journal of Immunology, 2019
Signaling through the mechanistic target of rapamycin complex 1 (mTORC1) is a major regulatory node of pro‐inflammatory mediator production by macrophages (MΦs).
M. William, L. Leroux, Visnu Chaparro, T. Graber, T. Alain, M. Jaramillo   +5 more
semanticscholar   +1 more source

The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1.

Molecules and Cells, 2021
R. Böhm, S. Imseng, R. Jakob, M. Hall, T. Maier, S. Hiller   +5 more
semanticscholar   +1 more source

Magnesium Supplement and the 15q11.2 BP1–BP2 Microdeletion (Burnside–Butler) Syndrome: A Potential Treatment?

International Journal of Molecular Sciences, 2019
The 15q11.2 BP1–BP2 microdeletion (Burnside–Butler) syndrome is an emerging disorder that encompasses four genes (NIPA1, NIPA2, CYFIP1, and TUBGCP5).
M. Butler
semanticscholar   +1 more source

PI3K-Akt-mTOR axis sustains rotavirus infection via the 4E-BP1 mediated autophagy pathway and represents an antiviral target

Virulence, 2017
Rotavirus infection is a major cause of severe dehydrating diarrhea in infants younger than 5 y old and in particular cases of immunocompromised patients irrespective to the age of the patients. Although vaccines have been developed, antiviral therapy is
Yuebang Yin, W. Dang, Xinying Zhou, Lei Xu, Wenshi Wang, W. Cao, Sunrui Chen, Junhong Su, Xuepeng Cai, Shaobo Xiao, M. Peppelenbosch, Q. Pan   +11 more
semanticscholar   +1 more source

Upregulation of the Nitrosylome in Bipolar Disorder Type 1 (BP1), but not BP2, and Major Depression: Increased IgM Antibodies to Nitrosylated Conjugates are Associated with Indicants of Leaky Gut

, 2019
Objective: Major depression (MDD) and a lifetime history of MDD are characterized by increased nitrosylation, while bipolar disorder type 1 (BP1), but not BP2, is accompanied by highly increased levels of oxidative stress and nitric oxide (NO) production.
M. Maes, D. Simeonova, D. Stoyanov, J. Leunis   +3 more
semanticscholar   +1 more source

The consequences of increased 4E-BP1 in polycystic kidney disease.

Human Molecular Genetics, 2019
Autosomal Dominant Polycystic kidney disease (ADPKD) is the most common hereditary renal disease, characterized by cyst formation and growth. Hyperproliferation is a major contributor to cyst growth.
S. Holditch, C. N. Brown, Daniel J. Atwood, Deepak Pokhrel, Sara E. Brown, A. M. Lombardi, Khoa N. Nguyen, Ryan C. Hill, M. Lanaspa, Katharina Hopp, M. Weiser-Evans, C. Edelstein   +11 more
semanticscholar   +1 more source

The 15q11.2 BP1–BP2 Microdeletion Syndrome: A Review

International Journal of Molecular Sciences, 2015
Patients with the 15q11.2 BP1–BP2 microdeletion can present with developmental and language delay, neurobehavioral disturbances and psychiatric problems. Autism, seizures, schizophrenia and mild dysmorphic features are less commonly seen. The 15q11.2 BP1–
Devin M Cox, M. Butler
semanticscholar   +1 more source

Expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy.

Brain : a journal of neurology, 2021
Lena H. Nguyen, Youfen Xu, Travorn Mahadeo, Longbo Zhang, Tiffany V. Lin, Heather A. Born, Anne E. Anderson, A. Bordey   +7 more
semanticscholar   +1 more source

Poster Sessions

HemaSphere, Volume 9, Issue S1, June 2025.
wiley   +1 more source

Proceedings from the 2024 Scandinavian Society of Anaesthesia and Intensive Care Congress in Oulu, Finland: Abstracts

Acta Anaesthesiologica Scandinavica, Volume 69, Issue 1, January 2025.
wiley   +1 more source