Results 21 to 30 of about 36,655 (113)

BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models

Nature Communications, 2021
Elucidation of non-canonical protein functions can identify novel tissue homeostasis pathways. Herein, we describe a role for the Bcl-2 family member BAD in postnatal mammary gland morphogenesis.
J. M. Githaka, Namita Tripathi, Raven Kirschenman, Namrata Patel, V. Pandya, D. A. Kramer, Rachel Montpetit, Lin‐Fu Zhu, N. Sonenberg, R. Fahlman, N. Danial, D. Underhill, I. Goping   +12 more
semanticscholar   +1 more source

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

MedComm, Volume 4, Issue 3, June 2023., 2023
The reversible and irreversible protein posttranslational modifications, such as acetylation, methylation, phosphorylation, ubiquitination, glycosylation, SUMOylation, and redox modifications, are essential regulators in organisms and cells. This work systematically summarizes the features, regulatory mechanisms, substrates, functions, and related ...
Qian Zhong, Xina Xiao, Yijie Qiu, Zhiqiang Xu, Chunyu Chen, Baochen Chong, Xinjun Zhao, Shan Hai, Shuangqing Li, Zhenmei An, Lunzhi Dai   +10 more
wiley   +1 more source

The 15q11.2 BP1-BP2 Microdeletion (Burnside–Butler) Syndrome: In Silico Analyses of the Four Coding Genes Reveal Functional Associations with Neurodevelopmental Disorders

International Journal of Molecular Sciences, 2020
The 15q11.2 BP1-BP2 microdeletion (Burnside–Butler) syndrome is emerging as the most frequent pathogenic copy number variation (CNV) in humans associated with neurodevelopmental disorders with changes in brain morphology, behavior, and cognition. In this
Syed K. Rafi, M. Butler
semanticscholar   +1 more source

Signaling pathways and intervention for therapy of type 2 diabetes mellitus

MedComm, Volume 4, Issue 3, June 2023., 2023
Cao et al. provide a comprehensive overview of signaling pathways in the pathogenesis and therapy of type 2 diabetes mellitus (T2DM) and its complications. Abstract Type 2 diabetes mellitus (T2DM) represents one of the fastest growing epidemic metabolic disorders worldwide and is a strong contributor for a broad range of comorbidities, including ...
Rong Cao, Huimin Tian, Yu Zhang, Geng Liu, Haixia Xu, Guocheng Rao, Yan Tian, Xianghui Fu   +7 more
wiley   +1 more source

Age‐related changes to adipose tissue and peripheral neuropathy in genetically diverse HET3 mice differ by sex and are not mitigated by rapamycin longevity treatment

Aging Cell, Volume 22, Issue 4, April 2023., 2023
Genetically diverse HET3 mice display sex‐dependent peripheral neuropathy phenotypes as a result of age. Longevity treatment rapamycin was unable to attenuate denervation and worsened adipose tissue inflammation and fibrosis. Abstract Neural communication between the brain and adipose tissues regulates energy expenditure and metabolism through ...
Jake W. Willows, Morganne Robinson, Zahra Alshahal, Samantha K. Morrison, Gargi Mishra, Harrison Cyr, Magdalena Blaszkiewicz, Gilian Gunsch, Sabrina DiPietro, Emma Paradie, Benjamin Tero, Anne Harrington, Larisa Ryzhova, Lucy Liaw, Peter C. Reifsnyder, David E. Harrison, Kristy L. Townsend   +16 more
wiley   +1 more source

The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

Nature Communications, 2019
Myofibroblasts are the key effector cells responsible for excessive extracellular matrix deposition in multiple fibrotic conditions, including idiopathic pulmonary fibrosis (IPF). The PI3K/Akt/mTOR axis has been implicated in fibrosis, with pan-PI3K/mTOR
Hannah V. Woodcock, J. Eley, D. Guillotin, M. Platé, C. Nanthakumar, Matteo Martufi, Simon Peace, G. Joberty, Daniel Poeckel, R. Good, Adam R. Taylor, N. Zinn, Matthew Redding, E. Forty, R. Hynds, C. Swanton, M. Karsdal, T. Maher, Andrew Fisher, G. Bergamini, R. Marshall, A. Blanchard, P. Mercer, R. Chambers   +23 more
semanticscholar   +1 more source

HAWC J2227+610 and Its Association with G106.3+2.7, a New Potential Galactic PeVatron [PDF]

Astrophysical Journal, 2020
We present the detection of very-high-energy gamma-ray emission above 100 TeV from HAWC J2227+610 with the High-Altitude Water Cherenov Gamma-Ray Observatory (HAWC) observatory.
A. Albert, R. Alfaro, C. Alvarez, J. Camacho, J. C. Arteaga-Vel'azquez, K. Arunbabu, D. Rojas, H. Solares, V. Baghmanyan, E. Belmont-Moreno, S. Benzvi, C. Brisbois, K. Caballero-Mora, T. Capistrán, A. Carramiñana, S. Casanova, U. Cotti, J. Cotzomi, S. León, E. D. L. Fuente, L. Díaz-Cruz, B. Dingus, M. DuVernois, J. C. Díaz-Vélez, R. Ellsworth, K. Engel, C. Espinoza, K. Fan, K. Fang, M. F. Alonso, H. Fleischhack, N. Fraija, A. Galv'an-G'amez, D. García, J. García-González, F. Garfias, G. Giacinti, M. Gonz'alez, J. Goodman, J. P. Harding, S. Hernández, J. Hinton, B. Hona, D. Huang, F. Hueyotl-Zahuantitla, P. Hüntemeyer, A. Iriarte, A. Jardin-Blicq, V. Joshi, William H. Lee, H. L. Vargas, J. Linnemann, A. Longinotti, G. Luis-Raya, J. Lundeen, K. Malone, S. Marinelli, O. Martinez, I. Martinez-Castellanos, J. Martínez-Castro, J. Matthews, P. Miranda-Romagnoli, J. Morales-Soto, E. Moreno, M. Mostafá, A. Nayerhoda, L. Nellen, M. Newbold, M. Nisa, R. Noriega-Papaqui, N. Omodei, A. Peisker, Y. Araujo, E. Pérez-Pérez, C. Rho, D. Rosa-González, E. Ruiz-Velasco, H. Salazar, F. Greus, A. Sandoval, M. Schneider, H. Schoorlemmer, J. S. Franco, G. Sinnis, A. Smith, R. Springer, P. Surajbali, E. Tabachnick, M. Tanner, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, F. Ureña-Mena, L. Villaseñor, T. Weisgarber, A. Zepeda, Hong-lei Zhou, C. D. Le'on, J. Álvarez   +99 more
semanticscholar   +1 more source

Association of congenital cardiovascular malformation and neuropsychiatric phenotypes with 15q11.2 (BP1–BP2) deletion in the UK Biobank

European Journal of Human Genetics, 2020
Deletion of a non-imprinted 500kb genomic region at chromosome 15q11.2, between breakpoints 1 and 2 of the Prader–Willi/Angelman locus (BP1–BP2 deletion), has been associated in previous studies with phenotypes including congenital cardiovascular ...
S. Williams, Apostol Nakev, Hui Guo, Simon Frain, Gennadiy Tenin, Anna Liakhovitskaia, Priyanka Saha, J. Priest, Kathryn E. Hentges, B. Keavney   +9 more
semanticscholar   +1 more source

4E-BP1 Protects Neurons from Misfolded Protein Stress and Parkinson's Disease Toxicity by Inducing the Mitochondrial Unfolded Protein Response

Journal of Neuroscience, 2020
Decline of protein quality control in neurons contributes to age-related neurodegenerative disorders caused by misfolded proteins. 4E-BP1 is a key node in the regulation of protein synthesis, as activated 4E-BP1 represses global protein translation ...
S. Dastidar, M. T. Pham, M. B. Mitchell, Steven G Yeom, Sarah Jordan, Angela Chang, B. Sopher, A. L. La Spada   +7 more
semanticscholar   +1 more source

CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability

Genes & Development, 2019
Here, Choi et al. show that CDK12, the RNA polymerase II C-terminal domain kinase, which regulates genome stability, expression of DNA repair genes, and cancer cell drug resistance, also phosphorylates the mRNA 5′ cap-binding repressor 4E-BP1 to promote ...
S. Choi, Thomas F. Martinez, Seongjae Kim, C. Donaldson, M. Shokhirev, A. Saghatelian, K. Jones   +6 more
semanticscholar   +1 more source