Results 111 to 120 of about 280,040 (268)

The business of process integration [PDF]

The paper describes the value of application integration and the place of business process management. It focuses on the duet BPM-SOA as the successful solution to build the adaptive enterprise of the near future.integration, ERP, enterprise applications,
Hurbean, Luminita
core   +1 more source

A simple and affordable protocol to assess censer seed dispersal: First confirmation of the mechanism in the genus Solanum

Applications in Plant Sciences, EarlyView.
Abstract Premise The censer seed dispersal mechanism, whereby mature fruits are retained on plants and seeds dispersed by mechanical shaking, is among the most specialized wind‐aided seed dispersal strategies employed by the flowering plants. An efficient, affordable, and easily repeatable protocol for determining whether a species uses this unusual ...
Abigail J. Motter, Christopher T. Martine, Melody P. Sain   +2 more
wiley   +1 more source

Expressing Properties of BPM Measurement System in Terms of Error Emittance and Error Twiss Parameters

, 2011
We show that properties of the beam position monitor (BPM) system designed for the measurement of transverse and energy beam jitters can be described in terms of the usual accelerator physics concepts of emittance, energy spread, dispersions and betatron
Balandin, Vladimir, Decking, Winfried, Golubeva, Nina   +2 more
core  

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Pharmacokinetics of dolutegravir, tenofovir and lamivudine during venous–venous extracorporeal membrane oxygenation (VV‐ECMO): A case report

British Journal of Clinical Pharmacology, EarlyView.
While providing potentially life‐saving cardiorespiratory support for critically ill patients, extracorporeal membrane oxygenation (ECMO) may detrimentally affect pharmacokinetic (PK) performance and concurrent drug efficacy and safety. We describe a patient with Pneumocystis jirovecii pneumonia (PJP) in the context of acquired immunodeficiency ...
Tom C. Zwart, Emiel Leegwater, Thomas H. Ottens, Emile F. Schippers, Erik B. Wilms, David M. Burger, Cees van Nieuwkoop, Liesbeth B. E. Bosma   +7 more
wiley   +1 more source

Convergencia entre la gestión de riesgos y la gestión por procesos: una revisión de la literatura

Innovar: Revista de Ciencias Administrativas y Sociales
El enfoque conjunto de la gestión por procesos y la gestión de riesgos constituye un marco gerencial integral. Mientras que la gestión por procesos se orienta a la mejora continua y la optimización de los métodos organizacionales, la gestión de riesgos ...
Hugo Santiago Aguirre Mayorga, Elisa del Carmen Navarro Romero   +1 more
doaj   +1 more source

Adipocytes in Aortic Stenosis: Association With Clinical and Morphological Indices

Clinical Anatomy, EarlyView.
ABSTRACT Recently, great attention has been given to understanding the new pathogenetic mechanisms underlying aortic stenosis (AS). The study aims to understand the role of mature adipocytes in AS and their association with histologic, clinical, and echocardiographic data, an area previously overlooked in AS research.
Elena Zoico, Tanaz Saatchi, Silvia Urbani, Vanni Rizzatti, Gloria Mazzali, Francesco Fantin, Silvia Faccioli, Alessandro Gavras, Mauro Zamboni, Anna Giani   +9 more
wiley   +1 more source

Difference Between Low‐Speed and High‐Speed Rotational Atherectomy Using Two Types of Guidewires

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Debulking devices are necessary to treat severe calcified lesions. Rotational atherectomy (RA) is widely employed to modify calcified plaques, but the influence of procedural variables, such as guidewire type and ablation speed, on ablation outcomes is not well established.
Akito Kawamura, Keita Okayama, Hiroaki Nohara, Tomoaki Nakano, Yasushi Sakata   +4 more
wiley   +1 more source

Clinical assessment of mocravimod as a victim of drug–drug interactions via CYP3A4 metabolism and transporters

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Mocravimod, a novel immunomodulator targeting sphingosine‐1‐phosphate receptor (S1PR), is being developed as a maintenance treatment for patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation. Preclinical data suggested that cytochrome (CYP) 3A4 is the primary enzyme involved in mocravimod metabolism.
Dymphy R. Huntjens, Stephan Oehen, Elisabeth Kueenburg   +2 more
wiley   +1 more source

The impact of forced closure on proppant distribution of hydraulic fracturing in shale formations

Deep Underground Science and Engineering, EarlyView.
Research findings demonstrate that implementing forced closure within shale formations can remarkably mitigate proppant settlement, concurrently increasing the effective propped surface area from 29.74% to 38.68%. Abstract Forced closure is widely used in conventional oil and gas reservoirs to promote uniform proppant placement.
Tongxuan Gu, Hanyi Wang, Quan Gan, Shuang Zheng   +3 more
wiley   +1 more source