Results 121 to 130 of about 123,103 (378)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
To brace or not to brace? [PDF]
The Journal of Bone and Joint Surgery. British volume, 1985 openaire +3 more sources
Cell, 2018 The detachment of plant organs is highly choreographed, requiring the enzymatic dissolution of the middle lamella between cell layers at the base of the detaching organ. Now, Lee et al. demonstrate that abscission efficiency and plant health rely on the spatial confinement of enzymatic activity and mechanical features that ensure a smooth separation.
openaire +2 more sources
The Research of United Energy Dissipated Design of Buckling Restrained Braces and Viscous Dampers for Frame Structure in High Seismic Region [PDF]
, 2018 Shu Wei Lan, Dong Hua Zhou
openalex +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Evaluation of the shear bond strength of the Orthobond composite under different conditions [PDF]
RGO: Revista Gaúcha de Odontologia, 2008 Objective: Evaluate the shear bond strength of metal brackets bonded with Orthobond composite (Dental Morelli Ltda, Sorocaba, Brazil) under different enamel surface conditions.
Antônio Carlos de Oliveira Ruellas +4 more
doaj
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Performance of Compression-Free Turnbuckle Braces Using Partially Fibered Cfrp
, 2022 Mizuki Hamasaki +6 more
openalex +1 more source