Results 131 to 140 of about 25,846 (308)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Semi-abelian categories, cocommutative Hopf algebras and Hopf braces

In this talk I’ll present some recent results on the interactions between Hopf algebra theory and semi-abelian categories. Semi-abelian categories [1] have played a central role in categorical algebra during the last 25 years.
Gran, Marino, The Interplay Between Skew Braces and Hopf-Galois Theory   +1 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Skew Braces of Finite Morley Rank

We describe skew braces of finite Morley rank. In particular, we derive sufficient and necessary conditions for the solubility and nilpotency of skew braces of finite Morley rank.
Invitti, Moreno, Ferrara, M, Trombetti, Marco, Wagner, Frank Olaf   +3 more
core   +3 more sources

What are the clinical recommendations for the use of ankle braces? A scoping review

JSAMS Plus
Background: Ankle braces can be used in the treatment and prevention of lateral ankle sprains. However, there is a limited understanding and consensus about which type of brace should be used, for how long, and when to stop using ankle braces. Objective:
Tomas Megalaa, Paula R. Beckenkamp, Alycia Fong Yan, Claire E. Hiller   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Woman with braces smiling

, 1990
Woman with braces ...

core  

Evaluating the Efficiency of Milwaukee Brace on Scoliosis Deformity: A Systematic Review of Literature [PDF]

Iranian Rehabilitation Journal
Objectives: Scoliosis is a three-dimensional deformity of the spine that can be treated using various treatment approaches. The use of braces is one of the most commonly used treatment methods for controlling curve progression.
Mohammad Taghi Karimi, Majid Ansari, Morteza Faghih Jouibari   +2 more
doaj