Results 151 to 160 of about 120,428 (365)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Long-term Outcomes of Traditional Braces versus Invisalign in Orthodontic Treatment

open access: yesJournal of Pharmacy and Bioallied Sciences
Objective: This research targets to compare the longstanding outcomes of traditional braces versus Invisalign in orthodontic treatment, focusing on dental alignment, occlusal stability, patient satisfaction, and treatment duration.
Seelam Prudhvi Das Reddy   +6 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

A Finite Element Analysis-Based Modeling and Evaluation Method for Sternum Support Brace

open access: yesIEEE Access
Sternum support braces are commonly used in thoracic surgery to secure the chest after open chest procedures. Despite their widespread use in postoperative recovery, current modeling and performance evaluation methods have significant limitations that ...
Linhua Lv   +3 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Evaluating the Efficiency of Milwaukee Brace on Scoliosis Deformity: A Systematic Review of Literature [PDF]

open access: yesIranian Rehabilitation Journal
Objectives: Scoliosis is a three-dimensional deformity of the spine that can be treated using various treatment approaches. The use of braces is one of the most commonly used treatment methods for controlling curve progression.
Mohammad Taghi Karimi   +2 more
doaj  

DUCTILITY CAPACITY STUDY OF LARGE-SCALE, BUCKLING-RESTRAINED BRACES IN STEEL STRUCTURES

open access: yesJournal of Sustainable Technologies and Materials
One of the new methods of anchoring steel structures is the use of large-scale buckling-restrained braces (BRBs) on the lateral system of this type of structure. This study investigates the behavior of BRBs and compares them with buckling braces. In this
Mohammad Amin Abdollahzadeh   +1 more
doaj   +1 more source

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