Results 31 to 40 of about 1,545 (120)

Expert opinion on the identification, risk assessment, and mitigation of microorganisms and parasites relevant to xenotransplantation products from pigs

Xenotransplantation, Volume 30, Issue 5, September/October 2023., 2023
Abstract Xenotransplantation has the potential to address shortages of organs available for clinical transplantation, but concerns exist regarding potential risks posed by porcine microorganisms and parasites (MP) to the health of human recipients. In this study, a risk‐based framework was developed, and expert opinion was elicited to evaluate porcine ...
Huybert Groenendaal, Solenne Costard, Reid Ballard, Stephen Bienhoff, Diana C. Challen, Brandon J. Dominguez, Douglas R. Kern, Dan Miller, Jeske Noordergraaf, Larisa Rudenko, Henk‐Jan Schuurman, Tom Spizzo, Matthew Sturos, Bill Zollers, Jay A. Fishman   +14 more
wiley   +1 more source

Antimicrobial susceptibility of U.S. porcine Brachyspira isolates and genetic diversity of B. hyodysenteriae by multilocus sequence typing. [PDF]

J Vet Diagn Invest, 2023
Swine dysentery, caused by Brachyspira hyodysenteriae and the newly recognized Brachyspira hampsonii in grower-finisher pigs, is a substantial economic burden in many swine-rearing countries.
Hakimi M, Ye F, Stinman CC, Sahin O, Burrough ER.   +4 more
europepmc   +2 more sources

Variation in hemolytic activity of Brachyspira hyodysenteriae strains from pigs [PDF]

, 2016
Brachyspira hyodysenteriae is the primary cause of swine dysentery, which is responsible for major economic losses to the pig industry worldwide. The hemolytic activity of 10 B.
Boyen, Filip, De Pauw, Nele, Ducatelle, Richard, Haesebrouck, Freddy, Mahu, Maxime, Martel, An, Pasmans, Frank, Vande Maele, Lien, Verlinden, Marc   +8 more
core   +4 more sources

Impairment of electroneutral Na⁺ transport and associated downregulation of NHE3 contributes to the development of diarrhea following in vivo challenge with Brachyspira spp.

Am J Physiol Gastrointest Liver Physiol, 2020
The effects of Brachyspira hyodysenteriae and Brachyspira hampsoniispirochetosis on Na+transport was assessed in the colon to determine its contribution to diarrheal disease, in pigs following experimental infection.
Enns CB, Keith BA, Challa N, Harding JCS, Loewen ME.   +4 more
europepmc   +2 more sources

Metabonomics-based analysis of Brachyspira pilosicoli's response to tiamulin reveals metabolic activity despite significant growth inhibition [PDF]

, 2017
Pathogenic anaerobes Brachyspira spp. are responsible for an increasing number of Intestinal Spirochaetosis (IS) cases in livestock against which few approved treatments are available.
Claus, Sandrine Paule, La Ragione, Roberto Marcello, Le Roy, Caroline Ivanne, Passey, Jade Louise, Woodward, Martin John   +4 more
core   +2 more sources

A novel multiplex qPCR targeting 23S rDNA for diagnosis of swine dysentery and porcine intestinal spirochaetosis [PDF]

, 2016
Figure S1. Consensus sequence alignment of the target DNA region within 23S ribosomal DNA. Primers (Brachy primer for. and Brachy primer rev.) on the target DNA are marked in grey. The probe for B. hyodysenteriae (Probe_hyo) is highlighted in yellow, the
Anna Borgström, Constanze Kirchgässner, Daniel Frei, Max M. Wittenbrink, Sarah Schmitt, Simone Scherrer   +5 more
core   +3 more sources

Brachyspira pilosicoli-induced avian intestinal spirochaetosis [PDF]

, 2015
Avian intestinal spirochetosis (AIS) is a common disease occurring in poultry that can be caused by Brachyspira pilosicoli, a Gram-negative bacterium of the order Spirochaetes. During AIS, this opportunistic pathogen colonises the lower gastrointestinal (
Eurostat, Ghorbani-Dalini, Hampson, Hovind-Hougen, Pretty, Stanton, USDA ERS, Wagenaar   +7 more
core   +2 more sources

Distribution, genetic heterogeneity, and antimicrobial susceptibility of Brachyspira pilosicoli in Swiss pig herds [PDF]

, 2022
Brachyspira (B.) pilosicoli is a bacterium causing porcine intestinal spirochaetosis, a disease characterized by diarrhoea and depressed growth rates especially in nursery and fattening pigs. Knowledge of the epidemiology and antimicrobial susceptibility
Arnold, M, Collaud, A, Hübschke, Ella, Nathues, Heiko, Perreten, Vincent, Rossano, A, Schmitt, S, Zeeh, Friederike   +7 more
core   +1 more source

Role of sialic acid in brachyspira hyodysenteriae adhesion to pig colonic mucins [PDF]

, 2019
Infection with Brachyspira hyodysenteriae results in mucoid hemorrhagic diarrhea. This pathogen is associated with the colonic mucus layer, mainly composed of mucins. Infection regulates mucin O-glycosylation in the colon and increases mucin secretion as
Haesebrouck, Freddy, Linden, Sara, Quintana-Hayashi, Macarena P., Venkatakrishnan, Vignesh   +3 more
core   +2 more sources

The levels of Brachyspira hyodysenteriae binding to porcine colonic mucins differ between individuals, and binding is increased to mucins from infected pigs with de novo MUC5AC synthesis [PDF]

, 2015
Brachyspira hyodysenteriae colonizes the pig colon, resulting in mucohemorrhagic diarrhea and growth retardation. Fecal mucus is a characteristic feature of swine dysentery; therefore, we investigated how the mucin environment changes in the colon during
Boyen, Filip, De Pauw, Nele, Fernandez, Harvey R, Haesebrouck, Freddy, Lindén, Sara K, Mahu, Maxime, Martel, An, Pasmans, Frank, Premaratne, Pushpa, Quintana-Hayashi, Macarena P, Teymournejad, Omid, Vande Maele, Lien   +11 more
core   +2 more sources