Results 51 to 60 of about 119,023 (342)

Targeting miR-423-5p Reverses Exercise Training–Induced HCN4 Channel Remodeling and Sinus Bradycardia

Circulation Research, 2017
Rationale: Downregulation of the pacemaking ion channel, HCN4 (hyperpolarization-activated cyclic nucleotide gated channel 4), and the corresponding ionic current, If, underlies exercise training–induced sinus bradycardia in rodents.
A. D’Souza, C. Pearman, Yanwen Wang, S. Nakao, S. Logantha, Charlotte Cox, H. Bennett, Yu Zhang, A. Johnsen, Nora Linscheid, P. C. Poulsen, J. Elliott, J. Coulson, Jamie McPhee, Abigail C. Robertson, P. A. da Costa Martins, A. Kitmitto, U. Wisløff, E. Cartwright, O. Monfredi, A. Lundby, H. Dobrzynski, D. Oceandy, G. Morris, M. Boyett   +24 more
semanticscholar   +1 more source

A Road Less Traveled: Successful Alcohol Septal Ablation via an Aberrant Septal Coronary Artery in Hypertrophic Obstructive Cardiomyopathy

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Alcohol septal ablation (ASA) is a minimally invasive treatment option for patients with hypertrophic obstructive cardiomyopathy (HOCM) who remain symptomatic despite medical treatment and are either poor surgical candidates or prefer a less invasive approach.
Vishnu Bharani, Vishal I. Patel, Morton J. Kern, Pranav M. Patel   +3 more
wiley   +1 more source

Cardiac Hypertrophy May Be a Risk Factor for the Development and Severity of Glaucoma

Biomedicines, 2022
The purpose of this study was to examine the relationship between glaucoma and cardiac abnormalities. We evaluated 581 patients with open-angle glaucoma (285 men and 296 women) and 595 individuals without glaucoma (273 men and 322 women).
Yukihisa Suzuki, Motohiro Kiyosawa
doaj   +1 more source

Pharmacokinetics and Safety Evaluation of a New Generic Sitafloxacin: A Phase I Bioequivalence Study in Healthy Chinese Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Sitafloxacin is a new antibiotic drug belonging to the fourth generation quinolone antibiotics. The aim of this study was to evaluate the pharmacokinetics (PK), safety profiles, and bioequivalence of test and reference 50‐mg sitafloxacin tablets under fasting and fed conditions.
Yongfang Lei, Pan Luo, Yuzhu Chen, Liuliang Xue, Donglin Zhang, Xingxing Qi, Yinian Fang, Hengyi Yu, Zheng He, Qin Zuo, Chang Liu, Dong Liu, Xinhua Ren, Qian Chen   +13 more
wiley   +1 more source

Multi-organ dysfunction following honeybee bite—A rare entity

Journal of Family Medicine and Primary Care, 2020
Honeybee bites have been known to cause localized allergic reactions and anaphylaxis but systemic toxic reactions leading to multiorgan dysfunction is very rare. Serious complications like acute renal failure, acute myocardial infarction (Kounis syndrome)
Satish Kumar Prasad, Sameer Kumar Mehta, Bhagyalakshmi Satyanarayan, Suman Kumar Panda   +3 more
doaj   +1 more source

Emergency transvenous temporary pacing during rotational atherectomy

Frontiers in Cardiovascular Medicine, 2023
BackgroundRotational atherectomy (RA) during percutaneous coronary intervention may cause transient bradycardia or a higher-degree heart block.
Konstantin Schwarz, Julia Mascherbauer, Elisabeth Schmidt, Martina Zirkler, Gudrun Lamm, Paul Vock, Chun Shing Kwok, Josip Andelo Borovac, Roya Anahita Mousavi, Uta C. Hoppe, Gregor Leibundgut, Maximilian Will, Maximilian Will   +12 more
doaj   +1 more source

Navigating Pharmacogenomic Testing in Practice: Who to Test and When to Test

Clinical Pharmacology &Therapeutics, EarlyView.
There is increasing attention on the clinical utility and value of pharmacogenetic (PGx) testing to individualize medication management. Most clinical practice guidelines from medical professional societies do not recommend routine PGx testing, with a few key exceptions.
James M. Stevenson, D. Max Smith, Sony Tuteja, Jai N. Patel, on behalf of the Pharmacogenomics Global Research Network (PGRN) Publications Committee   +4 more
wiley   +1 more source

Shared Decision Making and Cardioneuroablation Allow Discontinuation of Permanent Pacing in Patients with Vagally Mediated Bradycardia

Journal of Cardiovascular Development and Disease, 2023
Background: Safe discontinuation of pacemaker therapy for vagally mediated bradycardia is a dilemma. The aim of the study was to present the outcomes of a proposed diagnostic and therapeutic process aimed at discontinuing or not restoring pacemaker ...
Sebastian Stec, Antoni Wileczek, Agnieszka Reichert, Janusz Śledź, Jarosław Kosior, Dariusz Jagielski, Anna Polewczyk, Magdalena Zając, Andrzej Kutarski, Dariusz Karbarz, Dorota Zyśko, Łukasz Nowarski, Edyta Stodółkiewicz-Nowarska   +12 more
doaj   +1 more source

Infant Death due to Cannabis Ingestion

Drug Testing and Analysis, EarlyView.
ABSTRACT A child died in the emergency room of a local hospital a few hours after ingesting a substance the color of cork and the consistency of earth. At home, a modest amount of resinous substance was found. At the hospital, the child exhibited alterations in walking, balance, and consciousness.
Donata Favretto, Antonello Cirnelli, Roberto Pertile, Raffaella Stimamiglio, Clara Cestonaro, Oriana Cuman, Anna Pagliaro, Fabio Mattiazzi, Cristina Basso, Maddalena Galeazzi   +9 more
wiley   +1 more source

A randomised comparative study to compare the prophylactic use of phenylephrine and norepinephrine in caesarean delivery under spinal anaesthesia

Journal of Obstetric Anaesthesia and Critical Care, 2023
Background: To compare the efficacy and safety of prophylactic intravenous infusions of phenylephrine (0.1 μg/kg/min) and norepinephrine (NE) (0.05 μg/kg/min) for the management of maternal hypotension under spinal anesthesia for cesarean delivery ...
C V Soabir Ali, Jeetendra Kumar Bajaj
doaj   +1 more source