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Novel drug approval by the FDA: Ekterly (Sebetralstat), oral plasma kallikrein inhibitor for treating acute attacks of hereditary angioedema. [PDF]
Ann Med Surg (Lond)Gulalai, Miraj SA, Mahato RK.
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South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1996 openaire +1 more source
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Raman studies on bradykinin and a cyclic bradykinin
Peptides, 1982Laser Raman spectra of bradykinin in water, deuterium oxide, and the solid phase were recorded. From the spectra it was concluded that bradykinin conformation is comprised of ordered and unordered structure. The ordered structure appears to be some form of reverse turn.
J W, Fox +3 more
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Radioimmunoassay of Bradykinin
Nature, 1967IN the past few years highly sensitive and specific radioimmunological methods have been developed for the determination of many polypeptide hormones1. Radioimmunoassays are usually based on the competitive reaction of a measured amount of polypeptide hormone labelled with iodine-125 and iodine-131 and varying amounts of unlabelled hormone with hormone
H, Rinderknecht +2 more
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Nature, 1963
WHEN the nonapeptide bradykinin is injected into tissue certain effects follow1. These are: stimulation of smooth muscle, vasodilation with increased capillary permeability, and the production of pain. With large doses there is also attraction of masses of leucocytes to the injected site. No specific antagonist of bradykinin has yet been discovered and
R K, ARCHER, J, BROOME
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WHEN the nonapeptide bradykinin is injected into tissue certain effects follow1. These are: stimulation of smooth muscle, vasodilation with increased capillary permeability, and the production of pain. With large doses there is also attraction of masses of leucocytes to the injected site. No specific antagonist of bradykinin has yet been discovered and
R K, ARCHER, J, BROOME
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Pseudopeptide Analogs of Bradykinin and Bradykinin Antagonists
1992Over 100 reduced-bond analogs of bradykinin and bradykinin antagonists were designed, synthesized, and assayed in the classic smooth muscle and blood pressure assays in a further study of the structure-activity relationships of bradykinin. Both potent BK-like agonists and antagonists of BK activity were found among the reduced-bond analogs.
R J, Vavrek, L, Gera, J M, Stewart
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Origin and content of methionyl-lysyl-bradykinin, lysyl-bradykinin and bradykinin in human urine
Biochemical Pharmacology, 1976Abstract When human urine is collected in acid, three kinins, bradykinin (BK), lysyl-bradykinin (LBK, kallidin) and methionyl-lysyl-bradykinin (MLBK), are found. The identification of the MLBK was based on: (1) a chromatographic procedure which clearly separated it from BK and LBK, (2) its conversion by dipeptidyl aminopeptidase I to BK which was ...
V, Hial, H R, Keiser, J J, Pisano
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