Federation proceedings, 1979 So far the Cl inactivator, alpha 2-macroglobulin, antithrombin III (in the presence of heparin), and alpha 1-antitrypsin have been identified as inhibitors of plasma kallikrein; alpha 1-antitrypsin reacts slowly also with tissue kallikreins. Of the various naturally occurring kallikrein inhibitors the basic trypsin-kallikrein inhibitor of bovine organs,
Fink, Edwin +2 more
core +4 more sources
The 3(rd) International Symposium on Kallikreins and Kallikrein-Related Peptidases [PDF]
Biological Chemistry, 2010 No abstract ...
Fritz, Hans +3 more
core +4 more sources
Insights into platypus crural gland transcriptomics – venom and beyond [PDF]
BMC GenomicsBackground The platypus (Ornithorhynchus anatinus) is one of 15 confirmed venomous mammals worldwide, and possesses a unique venom system, termed the crural system.
Adele Gonsalvez +3 more
doaj +2 more sources
Drugs of the Kallikrein–Kinin System: An Overview [PDF]
Drugs and Drug Candidates, 2023 The kallikrein–kinin system consists of the two kininogen substrates present in the blood plasma, and two serine proteases: the plasma and tissue kallikreins.
François Marceau
doaj +2 more sources
Molecular biology of the kallikrein-kinin system: from structure to function [PDF]
Brazilian Journal of Medical and Biological Research, 1998 The participation of the kallikrein-kinin system, comprising the serine proteases kallikreins, the protein substrates kininogens and the effective peptides kinins, in some pathological processes like hypertension and cardiovascular diseases is still a ...
J.B. Pesquero, M. Bader
doaj +4 more sources
Inhibition of Growth and Induction of Apoptosis of Human Prostate Cancer Cells by Enzymatic Blockage of Kallikreins [PDF]
Prostate CancerFabienne Lehner +4 more
doaj +2 more sources
Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis
eLife, 2022 Atherosclerosis preferentially occurs in arterial regions exposed to disturbed blood flow (d-flow), while regions exposed to stable flow (s-flow) are protected.
Darian Williams +21 more
doaj +1 more source
Treatment of hereditary angioedema—single or multiple pathways to the rescue
Frontiers in Allergy, 2022 Hereditary angioedema (HAE) is a rare disease caused by mutations in the SERPING1 gene. This results in deficient or dysfunctional C1 esterase inhibitor (C1-INH) and affects multiple proteases involved in the complement, contact-system, coagulation, and ...
Anna Valerieva, Hilary J. Longhurst
doaj +1 more source
Interrelation among exercise training, cardiac hypertrophy, and tissue kallikrein-kinin system in athlete and non-athlete women [PDF]
Journal of Cardiovascular and Thoracic Research, 2022 Introduction: The tissue kallikrein-kinin system is an endogenous homeostatic pathway, which its stimulation is associated with cardioprotection. The present study aimed to determine the effect of exercise training on plasma tissue kallikrein (TK) and ...
Behnam Heidari +4 more
doaj +1 more source
Serine protease inhibitors decrease metastasis in prostate, breast, and ovarian cancers
Molecular Oncology, 2023 Targeted therapies for prostate, breast, and ovarian cancers are based on their activity against primary tumors rather than their anti‐metastatic activity. Consequently, there is an urgent need for new agents targeting the metastatic process.
Amiram Sananes +8 more
doaj +1 more source