Results 1 to 10 of about 3,839 (199)

[Biochemical remarks on therapy with kallikrein and kallikrein inactivator].

Langenbecks Archiv fur klinische Chirurgie ... vereinigt mit Deutsche Zeitschrift fur Chirurgie, 1998
openaire   +1 more source

Senescence and Hypoxia Regulate Colon Cancer Cell Transcriptome and Secretome: Insights into Cancer Cell Senescence Pathophysiology [PDF]

Biomolecules
We investigated the effects of senescence and hypoxia on the transcriptome and secretome of the colon cancer cell, HCT-116, in an in vitro model. Senescence was confirmed using SA-β Gal staining and the expression of p53 and p21 proteins, and hypoxia ...
Chandrasekharam N. Nagineni, Rajani Choudhuri, Murali C. Krishna, James B. Mitchell   +3 more
doaj   +2 more sources

Insights into platypus crural gland transcriptomics – venom and beyond [PDF]

BMC Genomics
Background The platypus (Ornithorhynchus anatinus) is one of 15 confirmed venomous mammals worldwide, and possesses a unique venom system, termed the crural system.
Adele Gonsalvez, Emma Peel, Carolyn J. Hogg, Katherine Belov   +3 more
doaj   +2 more sources

Kallikrein related peptidases 7 and 10 and their substrate desmoglein 3 are upregulated in early stage pancreatic cancerous lesions [PDF]

Scientific Reports
Differential expression of Kallikreins (KLKs) was described for established metastatic pancreatic ductal adenocarcinoma (PDAC), but their potential as markers for early detection is not known.
Jillian Eisenhauer, Ryan Argo, Alicia K. Fleming Martinez, Emir Maldosevic, Ligia I. Bastea, Cody J. Wehrkamp, Heike R. Döppler, Brandy H. Edenfield, Jason T. Lewis, Michael B. Wallace, Peter Storz   +10 more
doaj   +2 more sources

Dysregulated serum levels of human tissue kallikreins, hK7 and hK10, as potential biomarkers of asthma [PDF]

Biochemistry and Biophysics Reports
Background: Asthma is a highly prevalent inflammatory disease worldwide with limited diagnostic and therapeutic approaches. Objective: This study was conducted to explore the possible role of hK7 and hK10 in asthma progression and evaluate them as ...
Samina Ejaz, Faiz-ul-Hassan Nasim, Iqra Abdullah, Sami Ahmad, Muhammad Ashraf   +4 more
doaj   +2 more sources

Inhibition of Growth and Induction of Apoptosis of Human Prostate Cancer Cells by Enzymatic Blockage of Kallikreins [PDF]

Prostate Cancer
Fabienne Lehner, Souzan Salemi, Christopher Millan, Christoph Kündig, Daniel Eberli   +4 more
doaj   +2 more sources

Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis

eLife, 2022
Atherosclerosis preferentially occurs in arterial regions exposed to disturbed blood flow (d-flow), while regions exposed to stable flow (s-flow) are protected.
Darian Williams, Marwa Mahmoud, Renfa Liu, Aitor Andueza, Sandeep Kumar, Dong-Won Kang, Jiahui Zhang, Ian Tamargo, Nicolas Villa-Roel, Kyung-In Baek, Hwakyoung Lee, Yongjin An, Leran Zhang, Edward W Tate, Pritha Bagchi, Jan Pohl, Laurent O Mosnier, Eleftherios P Diamandis, Koichiro Mihara, Morley D Hollenberg, Zhifei Dai, Hanjoong Jo   +21 more
doaj   +1 more source

Treatment of hereditary angioedema—single or multiple pathways to the rescue

Frontiers in Allergy, 2022
Hereditary angioedema (HAE) is a rare disease caused by mutations in the SERPING1 gene. This results in deficient or dysfunctional C1 esterase inhibitor (C1-INH) and affects multiple proteases involved in the complement, contact-system, coagulation, and ...
Anna Valerieva, Hilary J. Longhurst
doaj   +1 more source

Interrelation among exercise training, cardiac hypertrophy, and tissue kallikrein-kinin system in athlete and non-athlete women [PDF]

Journal of Cardiovascular and Thoracic Research, 2022
Introduction: The tissue kallikrein-kinin system is an endogenous homeostatic pathway, which its stimulation is associated with cardioprotection. The present study aimed to determine the effect of exercise training on plasma tissue kallikrein (TK) and ...
Behnam Heidari, Mohammad Reza Zolfaghari, Kamal Khademvatani, Amir Fattahi, Reza Zarezadeh   +4 more
doaj   +1 more source

Serine protease inhibitors decrease metastasis in prostate, breast, and ovarian cancers

Molecular Oncology, 2023
Targeted therapies for prostate, breast, and ovarian cancers are based on their activity against primary tumors rather than their anti‐metastatic activity. Consequently, there is an urgent need for new agents targeting the metastatic process.
Amiram Sananes, Itay Cohen, Irit Allon, Oshrit Ben‐David, Raghda Abu Shareb, Ksenia M. Yegodayev, David Stepensky, Moshe Elkabets, Niv Papo   +8 more
doaj   +1 more source