Results 1 to 10 of about 20,465 (247)

Evolution of the plasma and tissue kallikreins, and their alternative splicing isoforms. [PDF]

PLoS ONE, 2013
Kallikreins are secreted serine proteases with important roles in human physiology. Human plasma kallikrein, encoded by the KLKB1 gene on locus 4q34-35, functions in the blood coagulation pathway, and in regulating blood pressure.
Vassiliki Lila Koumandou, Andreas Scorilas   +1 more
doaj   +2 more sources

Kallikreins 5, 6 and 10 differentially alter pathophysiology and overall survival in an ovarian cancer xenograft model. [PDF]

PLoS ONE, 2011
Human tissue kallikreins (KLKs) are members of a multigene family of serine proteases aberrantly expressed in many cancer types. In ovarian cancer, 12 KLKs are upregulated, and of those KLK5, 6 and 10 have been the focus of investigations into new ...
David Pépin, Zhong-Qi Shao, Geneviève Huppé, Andrea Wakefield, Chee-Wui Chu, Zahra Sharif, Barbara C Vanderhyden   +6 more
doaj   +2 more sources

Evolutionary history of tissue kallikreins. [PDF]

PLoS ONE, 2010
The gene family of human kallikrein-related peptidases (KLKs) encodes proteins with diverse and pleiotropic functions in normal physiology as well as in disease states.
Athanasia Pavlopoulou, Georgios Pampalakis, Ioannis Michalopoulos, Georgia Sotiropoulou   +3 more
doaj   +2 more sources

Insights into platypus crural gland transcriptomics – venom and beyond [PDF]

BMC Genomics
Background The platypus (Ornithorhynchus anatinus) is one of 15 confirmed venomous mammals worldwide, and possesses a unique venom system, termed the crural system.
Adele Gonsalvez, Emma Peel, Carolyn J. Hogg, Katherine Belov   +3 more
doaj   +2 more sources

Kallikrein related peptidases 7 and 10 and their substrate desmoglein 3 are upregulated in early stage pancreatic cancerous lesions [PDF]

Scientific Reports
Differential expression of Kallikreins (KLKs) was described for established metastatic pancreatic ductal adenocarcinoma (PDAC), but their potential as markers for early detection is not known.
Jillian Eisenhauer, Ryan Argo, Alicia K. Fleming Martinez, Emir Maldosevic, Ligia I. Bastea, Cody J. Wehrkamp, Heike R. Döppler, Brandy H. Edenfield, Jason T. Lewis, Michael B. Wallace, Peter Storz   +10 more
doaj   +2 more sources

Dysregulated serum levels of human tissue kallikreins, hK7 and hK10, as potential biomarkers of asthma [PDF]

Biochemistry and Biophysics Reports
Background: Asthma is a highly prevalent inflammatory disease worldwide with limited diagnostic and therapeutic approaches. Objective: This study was conducted to explore the possible role of hK7 and hK10 in asthma progression and evaluate them as ...
Samina Ejaz, Faiz-ul-Hassan Nasim, Iqra Abdullah, Sami Ahmad, Muhammad Ashraf   +4 more
doaj   +2 more sources

Gene network analyses point to the importance of human tissue kallikreins in melanoma progression

BMC Medical Genomics, 2011
Background A wide variety of high-throughput microarray platforms have been used to identify molecular targets associated with biological and clinical tumor phenotypes by comparing samples representing distinct pathological states.
Landman Gilles, Rezze Gisele G, Almeida Otávio M, Esteves Gustavo H, Martins Waleska K, Marques Sarah M, Carvalho Alex F, L Reis Luiz F, Duprat João P, Stolf Beatriz S   +9 more
doaj   +2 more sources

Inhibition of Growth and Induction of Apoptosis of Human Prostate Cancer Cells by Enzymatic Blockage of Kallikreins [PDF]

Prostate Cancer
Fabienne Lehner, Souzan Salemi, Christopher Millan, Christoph Kündig, Daniel Eberli   +4 more
doaj   +2 more sources

Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis

eLife, 2022
Atherosclerosis preferentially occurs in arterial regions exposed to disturbed blood flow (d-flow), while regions exposed to stable flow (s-flow) are protected.
Darian Williams, Marwa Mahmoud, Renfa Liu, Aitor Andueza, Sandeep Kumar, Dong-Won Kang, Jiahui Zhang, Ian Tamargo, Nicolas Villa-Roel, Kyung-In Baek, Hwakyoung Lee, Yongjin An, Leran Zhang, Edward W Tate, Pritha Bagchi, Jan Pohl, Laurent O Mosnier, Eleftherios P Diamandis, Koichiro Mihara, Morley D Hollenberg, Zhifei Dai, Hanjoong Jo   +21 more
doaj   +1 more source

Kallikreins emerge as new regulators of viral infections

Cellular and Molecular Life Sciences, 2021
Kallikrein-related peptidases (KLKs) or kallikreins have been linked to diverse (patho) physiological processes, such as the epidermal desquamation and inflammation, seminal clot liquefaction, neurodegeneration, and cancer.
G. Pampalakis, E. Zingkou, C. Panagiotidis, G. Sotiropoulou   +3 more
semanticscholar   +1 more source