Kinins’ Contribution to Postoperative Pain in an Experimental Animal Model and Its Implications [PDF]
Brain Sciences, 2023 Postoperative pain causes discomfort and disability, besides high medical costs. The search for better treatments for this pain is essential to improve recovery and reduce morbidity and risk of chronic postoperative pain.
Cassia Regina Silva +2 more
exaly +4 more sources
Involvement of the Kinin B1 Receptor in Increased Permeability of Cerebral Microvessels in Rats Subjected to Autoimmune Encephalomyelitis [PDF]
CellsKinins are vasoactive peptides that are involved in various cellular mechanisms, including the inflammatory response. Kinins, released in vessel walls, exacerbate inflammation by modulating the production and release of pro-inflammatory factors via two ...
Grzegorz Sulkowski +3 more
doaj +2 more sources
Effect of Kinins on the Hepatic Oxidative Stress in Mice Treated with a Methionine-Choline Deficient Diet [PDF]
Biomedicines, 2023 Non-alcoholic fatty liver is the leading cause of hepatic disease worldwide and ranges from simple steatosis to non-alcoholic steatohepatitis (NASH) due to cell injury, oxidative stress, and apoptosis.
Mariana Silva Thomaz +5 more
doaj +2 more sources
Kinins and Kinin Receptors in Cardiovascular and Renal Diseases
Pharmaceuticals, 2021 This review addresses the physiological role of the kallikrein–kinin system in arteries, heart and kidney and the consequences of kallikrein and kinin actions in diseases affecting these organs, especially ischemic and diabetic diseases.
François Alhenc-Gelas +2 more
exaly +3 more sources
A fluorescently-tagged tick kinin neuropeptide triggers peristalsis and labels tick midgut muscles [PDF]
Scientific ReportsTicks are blood-feeding arthropods that require heme for their successful reproduction. During feeding they also acquire pathogens that are subsequently transmitted to humans, wildlife and/or livestock.
Jonathan R. Hernandez +2 more
doaj +2 more sources
Role of Kinins in Hypertension and Heart Failure
Pharmaceuticals, 2020 The kallikrein–kinin system (KKS) is proposed to act as a counter regulatory system against the vasopressor hormonal systems such as the renin-angiotensin system (RAS), aldosterone, and catecholamines.
Suhail Hamid +3 more
doaj +1 more source
Journal of Translational Medicine, 2022 Background The kallikrein-kinin system is assumed to have a multifunctional role in health and disease, but its in vivo role in humans currently remains unclear owing to the divergence of plasma kinin level data published ranging from the low picomolar ...
Tanja Gangnus +2 more
doaj +1 more source
Identification of Human Kinin-Forming Enzyme Inhibitors from Medicinal Herbs
Molecules, 2021 The goal of this study was to assess the pharmacological effects of black tea (Camellia sinensis var. assamica) water extract on human kinin-forming enzymes in vitro. Tea is a highly consumed beverage in the world.
Hassan Madkhali +6 more
doaj +1 more source
Kinins and Their Receptors in Infectious Diseases
Pharmaceuticals, 2020 Kinins and their receptors have been implicated in a series of pathological alterations, representing attractive pharmacological targets for several diseases. The present review article aims to discuss the role of the kinin system in infectious diseases.
Ana Paula A. Dagnino +2 more
doaj +1 more source
A Systematic Review of Molecular Imaging Agents Targeting Bradykinin B1 and B2 Receptors
Pharmaceuticals, 2020 Kinins, bradykinin and kallidin are vasoactive peptides that signal through the bradykinin B1 and B2 receptors (B1R and B2R). B2R is constitutively expressed in healthy tissues and mediates responses such as vasodilation, fluid balance and retention ...
Joseph Lau +4 more
doaj +1 more source