Results 41 to 50 of about 6,579 (265)

Bradykinin, as a Reprogramming Factor, Induces Transdifferentiation of Brain Astrocytes into Neuron-like Cells

Biomedicines, 2021
Kinins are endogenous, biologically active peptides released into the plasma and tissues via the kallikrein-kinin system in several pathophysiological events. Among kinins, bradykinin (BK) is widely distributed in the periphery and brain. Several studies
Tsong-Hai Lee, Pei-Shan Liu, Su-Jane Wang, Ming-Ming Tsai, Velayuthaprabhu Shanmugam, Hsi-Lung Hsieh   +5 more
doaj   +1 more source

The Cattle Fever Tick, Rhipicephalus microplus, as a Model for Forward Pharmacology to Elucidate Kinin GPCR Function in the Acari

Frontiers in Physiology, 2019
The success of the acaricide amitraz, a ligand of the tick tyramine/octopamine receptor (a G protein-coupled receptor; GPCR), stimulated interest on arthropod-specific GPCRs as targets to control tick populations.
Caixing Xiong, Dwight Baker, Patricia V. Pietrantonio   +2 more
doaj   +1 more source

Altered glucose homeostasis and hepatic function in obese mice deficient for both kinin receptor genes. [PDF]

PLoS ONE, 2012
The Kallikrein-Kinin System (KKS) has been implicated in several aspects of metabolism, including the regulation of glucose homeostasis and adiposity. Kinins and des-Arg-kinins are the major effectors of this system and promote their effects by binding ...
Carlos C Barros, Anderson Haro, Fernanda J V P Russo, Ines Schadock, Sandro S Almeida, Rosane A Ribeiro, Emerielle C Vanzela, Valeria P Lanzoni, Flavio C Barros, Milton R Moraes, Marcelo A Mori, Reury F P Bacurau, Martin Wurtele, Antônio C Boschero, Everardo M Carneiro, Michael Bader, Joao B Pesquero, Ronaldo C Araujo   +17 more
doaj   +1 more source

Kinins and Their Receptors as Potential Therapeutic Targets in Retinal Pathologies

Cells, 2021
The kallikrein-kinin system (KKS) contributes to retinal inflammation and neovascularization, notably in diabetic retinopathy (DR) and neovascular age-related macular degeneration (AMD).
Rahmeh Othman, Gael Cagnone, Jean-Sébastien Joyal, Elvire Vaucher, Réjean Couture   +4 more
doaj   +1 more source

Kinins as mediators of intestinal secretion

, 1989
Kinins are small peptides that have diverse biological actions. Concentrations of kinins in the nanomolar or subnanomolar range induce intestinal smooth muscle contraction and evoke mucosal electrolyte secretion.
J. F. Kachur, T. S. Gaginella
core   +1 more source

Non-Pharmacological Activation of the Renal Kallikrein–Kinin System: Dietary Potassium as a Novel Renoprotective Approach

Drugs and Drug Candidates
Chronic kidney disease (CKD) has emerged as a pervasive global health concern, for which there are no known curative treatments. Consequently, there is an imperative for the implementation of preventive and kidney-protective strategies.
Leopoldo Ardiles, Carlos D. Figueroa
doaj   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Reliable measurement of plasma kinin peptides: Importance of preanalytical variables

Research and Practice in Thrombosis and Haemostasis, 2022
Background The kallikrein‐kinin system is involved in many (patho)physiological processes and kinin peptides are considered potential clinical biomarkers.
Tanja Gangnus, Bjoern B. Burckhardt
doaj   +1 more source

Kinins and endothelial control of vascular smooth muscle

, 1995
Plasma and vascular kinins stimulate the production of endothelium-derived nitric oxide, prostacyclin and hyperpolarizing factor (which regulates the function of vascular smooth muscle), and endothelial interactions with blood cells.
Vanhoutte, PM, Mombouli, JV
core   +1 more source

The Mitogen‐Activated Protein Kinase GhNTF3 Modulates the Arbuscular Mycorrhizal Symbiosis‐Immunity Trade‐Off in Cotton by Regulating Salicylic Acid Biosynthesis

Advanced Science, EarlyView.
AM symbiosis induces GhWAK13 to promote fungal colonization. GhNTF3 negatively regulates symbiosis by promoting SA biosynthesis. GhWAK13 sequesters GhNTF3 at the membrane, limiting its nuclear translocation and relieving SA‐mediated suppression. Under Verticillium stress, GhNTF3 enters the nucleus and interacts with GhJAZ6 to activate SA signaling ...
Shuangjie Jia, Jingshang Wen, Jihang Li, Meina Feng, Yiming He, Ruojun Liu, Qian Liu, Junli Zhang, Kai Cheng, Xiangyu Zhang, Xiao Zhang   +10 more
wiley   +1 more source