American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2000 The kinin peptide system in humans is complex. Whereas plasma kallikrein generates bradykinin peptides, glandular kallikrein generates kallidin peptides. Moreover, a proportion of kinin peptides is hydroxylated on proline3of the bradykinin sequence. We established HPLC-based radioimmunoassays for nonhydroxylated and hydroxylated bradykinin and kallidin
A M, Duncan +5 more
openaire +2 more sources
Identification of Human Kinin-Forming Enzyme Inhibitors from Medicinal Herbs
Molecules, 2021 The goal of this study was to assess the pharmacological effects of black tea (Camellia sinensis var. assamica) water extract on human kinin-forming enzymes in vitro. Tea is a highly consumed beverage in the world.
Hassan Madkhali +6 more
doaj +1 more source
A Systematic Review of Molecular Imaging Agents Targeting Bradykinin B1 and B2 Receptors
Pharmaceuticals, 2020 Kinins, bradykinin and kallidin are vasoactive peptides that signal through the bradykinin B1 and B2 receptors (B1R and B2R). B2R is constitutively expressed in healthy tissues and mediates responses such as vasodilation, fluid balance and retention ...
Joseph Lau +4 more
doaj +1 more source
A tissue kallikrein in the synovial fluid of patients with rheumatoid arthritis [PDF]
, 1989 Tissue kallikrein is an enzyme that forms the vasoactive peptide kallidin from an endogenous substrate L-kininogen. Tissue kallikrein has been identified in joint fluids and in inflammatory infiltrates within synovial membranes.
Bhoola, K. D. +5 more
core +1 more source
Biomedicines, 2023 Background: Chronic kidney disease (CKD) is a multifactorial, world public health problem that often develops as a consequence of acute kidney injury (AKI) and inflammation.
Gabriel Rufino Estrela +5 more
doaj +1 more source
Extracellular aspartic protease SAP2 of Candida albicans yeast cleaves human kininogens and releases proinflammatory peptides, Met-Lys-bradykinin and des-Arg(9)-Met-Lys-bradykinin [PDF]
, 2012 Bradykinin-related peptides, universal mediators of inflammation collectively referred to as the kinins, are often produced in excessive amounts during microbial infections.
Guevara-Lora, Ibeth +7 more
core +1 more source
Visualisation of tissue kallikrein, kininogen and kinin receptors in human skin following trauma and in dermal diseases [PDF]
, 2004 During dermal injury and inflammation the serine proteases kallikreins cleave endogenous, multifunctional substrates (kininogens) to form bradykinin and kallidin.
Valeske, Klaus +15 more
core +1 more source
Molecular biology of the kallikrein-kinin system: from structure to function
Brazilian Journal of Medical and Biological Research, 1998 The participation of the kallikrein-kinin system, comprising the serine proteases kallikreins, the protein substrates kininogens and the effective peptides kinins, in some pathological processes like hypertension and cardiovascular diseases is still a ...
J.B. Pesquero, M. Bader
doaj +1 more source
Bi-directional actions of estrogen on the renin-angiotensin system
Brazilian Journal of Medical and Biological Research, 1999 Estrogen stimulates the renin-angiotensin system by augmenting both tissue and circulating levels of angiotensinogen and renin. We show, however, that angiotensin converting enzyme (ACE) activity in the circulation and in tissues is reduced in two animal
K.B. Brosnihan +3 more
doaj +1 more source
A role for extracellular amastigotes in the immunopathology of Chagas disease [PDF]
Memorias do Instituto Oswaldo Cruz, 1999 In spite of the growing knowledge obtained about immune control of Trypanosoma cruzi infection, the mechanisms responsible for the variable clinico-pathological expression of Chagas disease remain unknown.
Julio Scharfstein, Alexandre Morrot
doaj +1 more source