Results 11 to 20 of about 4,812 (241)

Kinins in humans [PDF]

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2000
The kinin peptide system in humans is complex. Whereas plasma kallikrein generates bradykinin peptides, glandular kallikrein generates kallidin peptides. Moreover, a proportion of kinin peptides is hydroxylated on proline3of the bradykinin sequence. We established HPLC-based radioimmunoassays for nonhydroxylated and hydroxylated bradykinin and kallidin
A M, Duncan, A, Kladis, G L, Jennings, A M, Dart, M, Esler, D J, Campbell   +5 more
openaire   +2 more sources

The Kallikrein-Kinin System: Current and Future Pharmacological Targets

Journal of Pharmacological Sciences, 2005
The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). This complex system includes the precursors of kinins known as kininogens and mainly tissue and
Marie Eve Moreau, Nancy Garbacki, Giuseppe Molinaro, Nancy J. Brown, François Marceau, Albert Adam   +5 more
doaj   +1 more source

Kinin B1 Receptor Antagonism Prevents Acute Kidney Injury to Chronic Kidney Disease Transition in Renal Ischemia-Reperfusion by Increasing the M2 Macrophages Population in C57BL6J Mice

Biomedicines, 2023
Background: Chronic kidney disease (CKD) is a multifactorial, world public health problem that often develops as a consequence of acute kidney injury (AKI) and inflammation.
Gabriel Rufino Estrela, Raisa Brito Santos, Alexandre Budu, Adriano Cleis de Arruda, Jonatan Barrera-Chimal, Ronaldo Carvalho Araújo   +5 more
doaj   +1 more source

Molecular biology of the kallikrein-kinin system: from structure to function

Brazilian Journal of Medical and Biological Research, 1998
The participation of the kallikrein-kinin system, comprising the serine proteases kallikreins, the protein substrates kininogens and the effective peptides kinins, in some pathological processes like hypertension and cardiovascular diseases is still a ...
J.B. Pesquero, M. Bader
doaj   +1 more source

Bi-directional actions of estrogen on the renin-angiotensin system

Brazilian Journal of Medical and Biological Research, 1999
Estrogen stimulates the renin-angiotensin system by augmenting both tissue and circulating levels of angiotensinogen and renin. We show, however, that angiotensin converting enzyme (ACE) activity in the circulation and in tissues is reduced in two animal
K.B. Brosnihan, P.S. Senanayake, P. Li, C.M. Ferrario   +3 more
doaj   +1 more source

A role for extracellular amastigotes in the immunopathology of Chagas disease [PDF]

Memorias do Instituto Oswaldo Cruz, 1999
In spite of the growing knowledge obtained about immune control of Trypanosoma cruzi infection, the mechanisms responsible for the variable clinico-pathological expression of Chagas disease remain unknown.
Julio Scharfstein, Alexandre Morrot
doaj   +1 more source

Angiotensin-Converting Enzyme Inhibitor Protects Against Cisplatin Nephrotoxicity by Modulating Kinin B1 Receptor Expression and Aminopeptidase P Activity in Mice

Frontiers in Molecular Biosciences, 2020
Cisplatin is a highly effective chemotherapeutic agent. However, its use is limited by nephrotoxicity. Enalapril is an angiotensin I-converting enzyme inhibitor used for the treatment of hypertension, mainly through the reduction of angiotensin II ...
Gabriel R. Estrela, Gabriel R. Estrela, Frederick Wasinski, Marcos F. Gregnani, Leandro C. Freitas-Lima, Adriano C. Arruda, Rafael Leite Morais, Denise MAC Malheiros, Niels O. S. Camara, João Bosco Pesquero, Michael Bader, Michael Bader, Michael Bader, Michael Bader, Carlos Castilho Barros, Ronaldo Carvalho Araújo, Ronaldo Carvalho Araújo   +16 more
doaj   +1 more source

Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury

Molecules, 2010
Injury to the central nervous system initiates complex physiological, cellular and molecular processes that can result in neuronal cell death. Of interest to this review is the activation of the kinin family of neuropeptides, in particular bradykinin and
Anna V Leonard, Robert Vink, Emma Thornton, Jenna M Ziebell   +3 more
doaj   +1 more source

Evidence for the presence of a kininogen-like species in a case of total deficiency of low and high molecular weight kininogens

Brazilian Journal of Medical and Biological Research, 1998
Low and high molecular weight kininogens (LK and HK), containing 409 and 626 amino acids with masses of ~65 and 120 kDa after glycosylation, respectively, are coded by a single gene mapped to the human chromosome 3 by alternative splicing of the ...
D. Veloso
doaj   +1 more source

Deletion of Kinin B2 Receptor Alters Muscle Metabolism and Exercise Performance. [PDF]

PLoS ONE, 2015
Metabolic syndrome is a cluster of metabolic risk factors such as obesity, diabetes and cardiovascular diseases. Mitochondria is the main site of ATP production and its dysfunction leads to decreased oxidative phosphorylation, resulting in lipid ...
Felipe C G Reis, Anderson S Haro, Aline V N Bacurau, Sandro M Hirabara, Frederick Wasinski, Milene S Ormanji, José B N Moreira, Beatriz H Kiyomoto, Clelia R A Bertoncini, Patricia C Brum, Rui Curi, Michael Bader, Reury F P Bacurau, João B Pesquero, Ronaldo C Araújo   +14 more
doaj   +1 more source