Results 11 to 20 of about 6,579 (265)
Kinins and Kinin Receptors in Cardiovascular and Renal Diseases [PDF]
Pharmaceuticals, 2021 This review addresses the physiological role of the kallikrein–kinin system in arteries, heart and kidney and the consequences of kallikrein and kinin actions in diseases affecting these organs, especially ischemic and diabetic diseases.
François Alhenc-Gelas +2 more
exaly +5 more sources
Kinins’ Contribution to Postoperative Pain in an Experimental Animal Model and Its Implications [PDF]
Brain Sciences, 2023 Postoperative pain causes discomfort and disability, besides high medical costs. The search for better treatments for this pain is essential to improve recovery and reduce morbidity and risk of chronic postoperative pain.
Indiara Brusco +3 more
doaj +3 more sources
Role of Kinins in Hypertension and Heart Failure [PDF]
Pharmaceuticals, 2020 The kallikrein–kinin system (KKS) is proposed to act as a counter regulatory system against the vasopressor hormonal systems such as the renin-angiotensin system (RAS), aldosterone, and catecholamines.
Suhail Hamid +3 more
doaj +4 more sources
Kinins and Their Receptors in Infectious Diseases [PDF]
Pharmaceuticals, 2020 Kinins and their receptors have been implicated in a series of pathological alterations, representing attractive pharmacological targets for several diseases. The present review article aims to discuss the role of the kinin system in infectious diseases.
Ana Paula A. Dagnino +2 more
doaj +2 more sources
Involvement of the Kinin B1 Receptor in Increased Permeability of Cerebral Microvessels in Rats Subjected to Autoimmune Encephalomyelitis [PDF]
CellsKinins are vasoactive peptides that are involved in various cellular mechanisms, including the inflammatory response. Kinins, released in vessel walls, exacerbate inflammation by modulating the production and release of pro-inflammatory factors via two ...
Grzegorz Sulkowski +3 more
doaj +2 more sources
The Kallikrein-Kinin System: Current and Future Pharmacological Targets
Journal of Pharmacological Sciences, 2005 The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). This complex system includes the precursors of kinins known as kininogens and mainly tissue and
Nancy J. Brown +2 more
exaly +3 more sources
Effect of Kinins on the Hepatic Oxidative Stress in Mice Treated with a Methionine-Choline Deficient Diet [PDF]
Biomedicines, 2023 Non-alcoholic fatty liver is the leading cause of hepatic disease worldwide and ranges from simple steatosis to non-alcoholic steatohepatitis (NASH) due to cell injury, oxidative stress, and apoptosis.
Mariana Silva Thomaz +5 more
doaj +2 more sources
A fluorescently-tagged tick kinin neuropeptide triggers peristalsis and labels tick midgut muscles [PDF]
Scientific ReportsTicks are blood-feeding arthropods that require heme for their successful reproduction. During feeding they also acquire pathogens that are subsequently transmitted to humans, wildlife and/or livestock.
Jonathan R. Hernandez +2 more
doaj +2 more sources
Inflammation, kinins, and kinin receptors [PDF]
, 2008 Evidence is accumulating that the pathogenesis of many diseases is triggered by inappropriate inflammatory responses. These serious complications may occur when the tightly regulated inflammatory network is out of balance and it is now clear that this can eventually cause substantial harm to own cells and tissues.
Bengtson, Sara
openaire +3 more sources
Journal of Translational Medicine, 2022 Background The kallikrein-kinin system is assumed to have a multifunctional role in health and disease, but its in vivo role in humans currently remains unclear owing to the divergence of plasma kinin level data published ranging from the low picomolar ...
Tanja Gangnus +2 more
doaj +1 more source