Results 1 to 10 of about 38,460 (214)

Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation

Nature reviews. Immunology, 2021
During severe inflammatory and infectious diseases, various mediators modulate the equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review describes the interactive roles of the renin–angiotensin system, the complement system,
Zivile Bekassy, Ingrid Lopatko Fagerström, M. Bader, D. Karpman   +3 more
semanticscholar   +1 more source

Safety and Outcomes Associated with the Pharmacological Inhibition of the Kinin–Kallikrein System in Severe COVID-19

Viruses, 2021
Background: Coronavirus disease 19 (COVID-19) can develop into a severe respiratory syndrome that results in up to 40% mortality. Acute lung inflammatory edema is a major pathological finding in autopsies explaining O2 diffusion failure and hypoxemia ...
Eli Mansour, A. Palma, R. G. Ulaf, L. C. Ribeiro, A. F. Bernardes, T. A. Nunes, Marcus V. Agrela, Bruna Bombassaro, M. Monfort-Pires, R. L. Camargo, E. Araújo, N. S. Brunetti, Alessandro S Farias, A. L. Falcão, T. M. Santos, P. Trabasso, R. P. Dertkigil, S. Dertkigil, M. Moretti, L. Velloso   +19 more
semanticscholar   +1 more source

Specific Targeting of Plasma Kallikrein for Treatment of Hereditary Angioedema: A Revolutionary Decade.

Journal of Allergy and Clinical Immunology: In Practice, 2021
Hereditary angioedema (HAE) is a rare, chronic, genetic disease that presents with nonpruritic angioedema of the face, extremities, airway (can be life-threatening), genitourinary system, and abdomen.
P. Busse, Allen Kaplan
semanticscholar   +1 more source

Reviewing clinical considerations and guideline recommendations of C1 inhibitor prophylaxis for hereditary angioedema

Clinical and Translational Allergy, 2022
Background Hereditary angioedema (HAE), a rare disease that is characterized by painful and recurring non‐allergic swelling episodes, is caused by the deficiency or dysfunction of C1 inhibitor (C1INH) protein.
John Anderson, Njeri Maina
doaj   +1 more source

Kallikrein‐1 Blockade Inhibits Aortic Expansion in a Mouse Model and Reduces Prostaglandin E2 Secretion From Human Aortic Aneurysm Explants

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. The kinin B2 receptor agonist, bradykinin, has been implicated in AAA pathogenesis through promoting inflammation.
Corey S. Moran, Erik Biros, Smriti M. Krishna, Susan K. Morton, Daniel J. Sexton, Jonathan Golledge   +5 more
doaj   +1 more source

Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome

eLife, 2020
COVID-19 patients can present with pulmonary edema early in disease. We propose that this is due to a local vascular problem because of activation of bradykinin 1 receptor (B1R) and B2R on endothelial cells in the lungs.
F. L. van de Veerdonk, M. Netea, M. van Deuren, J. V. D. van der Meer, Q. de Mast, R. Brüggemann, H. van der Hoeven   +6 more
semanticscholar   +1 more source

Pathophysiological Response to SARS-CoV-2 Infection Detected by Infrared Spectroscopy Enables Rapid and Robust Saliva Screening for COVID-19

Biomedicines, 2022
Fourier transform infrared (FTIR) spectroscopy provides a (bio)chemical snapshot of the sample, and was recently used in proof-of-concept cohort studies for COVID-19 saliva screening.
Seth T. Kazmer, Gunter Hartel, Harley Robinson, Renee S. Richards, Kexin Yan, Sebastiaan J. van Hal, Raymond Chan, Andrew Hind, David Bradley, Fabian Zieschang, Daniel J. Rawle, Thuy T. Le, David W. Reid, Andreas Suhrbier, Michelle M. Hill   +14 more
doaj   +1 more source

Blood Kallikrein-8 and Non-Amnestic Mild Cognitive Impairment: An Exploratory Study

Journal of Alzheimer's Disease Reports, 2023
Background: Blood kallikrein-8 is supposed to be a biomarker for mild cognitive impairment (MCI) due to Alzheimer’s disease (AD), a precursor of AD dementia. Little is known about the association of kallikrein-8 and non-AD type dementias.
Sara Schramm, Nela Krizanovic, Ulla Roggenbuck, Karl-Heinz Jöckel, Arne Herring, Kathy Keyvani, Martha Jokisch   +6 more
doaj   +1 more source

The contact system proteases play disparate roles in streptococcal sepsis

Haematologica, 2020
Sepsis causes an activation of the human contact system, an inflammatory response mechanism against foreign surfaces, proteins and pathogens. The serine proteases of the contact system, factor XII and plasma kallikrein, are decreased in plasma of septic ...
Juliane Köhler, Claudia Maletzki, Dirk Koczan, Marcus Frank, Carolin Trepesch, Alexey S. Revenko, Jeffrey R. Crosby, A. Robert Macleod, Stefan Mikkat, Sonja Oehmcke-Hecht   +9 more
doaj   +1 more source

Blocking domain 6 of high molecular weight kininogen to understand intrinsic clotting mechanisms

Research and Practice in Thrombosis and Haemostasis, 2022
Background The contact system is initiated by factor (F) XII activation and the assembly of high molecular weight kininogen (HK) with either FXI or prekallikrein (PK) on a negatively charged surface.
Pradeep K. Singh, Zu‐Lin Chen, Katharina Horn, Erin H. Norris   +3 more
doaj   +1 more source