Results 21 to 30 of about 38,460 (214)

Twenty year Risk of Prostate Cancer Death by Midlife Prostate specific Antigen and a Panel of Four Kallikrein Markers in a Large Population based Cohort of Healthy Men

European Urology, 2018
Background Prostate-specific antigen (PSA) screening reduces prostate cancer deaths but leads to harm from overdiagnosis and overtreatment. Objective To determine the long-term risk of prostate cancer mortality using kallikrein blood markers measured at ...
D. Sjoberg, A. Vickers, M. Assel, A. Dahlin, Bing Ying Poon, D. Ulmert, H. Lilja   +6 more
semanticscholar   +1 more source

The Long-Term Outcome Comparison of Different Time-Delayed Kallikrein Treatments in a Mouse Cerebral Ischemic Model

Stem Cells International, 2018
Delayed administration of kallikrein after cerebral infarction can improve neurological function. However, the appropriate kallkrein treatment time after ischemic stroke has not been illuminated.
Yaohui Ni, Kefu Cai, Yujie Hu, Chuan-hui Wang, Yuanyuan Zhang, Hua Huang, Xing Su, Jin-hua Gu   +7 more
doaj   +1 more source

Evaluation of avoralstat, an oral kallikrein inhibitor, in a Phase 3 hereditary angioedema prophylaxis trial: The OPuS‐2 study

Allergy. European Journal of Allergy and Clinical Immunology, 2018
Effective inhibition of plasma kallikrein may have significant benefits for patients with hereditary angioedema due to deficiency of C1 inhibitor (C1‐INH‐HAE) by reducing the frequency of angioedema attacks.
M. Riedl, E. Aygören‐Pürsün, J. Baker, H. Farkas, John Anderson, J. Bernstein, L. Bouillet, P. Busse, M. Manning, M. Magerl, M. Gompels, A. Huissoon, H. Longhurst, W. Lumry, B. Ritchie, R. Shapiro, D. Soteres, A. Banerji, M. Cancian, D. Johnston, T. Craig, D. Launay, H. Li, M. Liebhaber, T. Nickel, J. Offenberger, W. Rae, R. Schrijvers, M. Triggiani, H. Wedner, S. Dobo, M. Cornpropst, D. Clemons, L. Fang, P. Collis, W. Sheridan, Marcus Maurer   +36 more
semanticscholar   +1 more source

Kallikrein‐8 inhibition attenuates Alzheimer's disease pathology in mice

Alzheimer's & Dementia, 2016
Memory loss and increased anxiety are clinical hallmarks of Alzheimer's disease (AD). Kallikrein‐8 is a protease implicated in memory acquisition and anxiety, and its mRNA is known to be up‐regulated in AD‐affected human hippocampus.
Arne Herring, Yvonne Münster, T. Akkaya, S. Moghaddam, Katharina Deinsberger, Jakob Meyer, Julia Zahel, Eduardo H. Sanchez-Mendoza, Yachao Wang, Dirk M. Hermann, T. Arzberger, Sarah Teuber-Hanselmann, K. Keyvani   +12 more
semanticscholar   +1 more source

Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond

Frontiers in Physiology, 2023
Human plasma kallikrein (PKa) is obtained by activating its precursor, prekallikrein (PK), historically named the Fletcher factor. Human PKa and tissue kallikreins are serine proteases from the same family, having high- and low-molecular weight ...
Guacyara Motta, Luiz Juliano, Jair Ribeiro Chagas   +2 more
doaj   +1 more source

Exogenous kallikrein protects against diabetic nephropathy.

Kidney International, 2016
The kallikrein-kinin system has been shown to be involved in the development of diabetic nephropathy, but specific mechanisms are not fully understood. Here, we determined the renal-protective role of exogenous pancreatic kallikrein in diabetic mice and ...
Wenjuan Liu, Yeping Yang, Yemei Liu, Xiaolan Lu, Shizhe Guo, Meng Wu, Meng Wang, Linling Yan, Qinghua Wang, Xiaolong Zhao, Xian Tong, Ji Hu, Yiming Li, R. Hu, R. Stanton, Zhaoyun Zhang   +15 more
semanticscholar   +1 more source

Non-Pharmacological Activation of the Renal Kallikrein–Kinin System: Dietary Potassium as a Novel Renoprotective Approach

Drugs and Drug Candidates
Chronic kidney disease (CKD) has emerged as a pervasive global health concern, for which there are no known curative treatments. Consequently, there is an imperative for the implementation of preventive and kidney-protective strategies.
Leopoldo Ardiles, Carlos D. Figueroa
doaj   +1 more source

Interference of kallikrein 1b26 (klk1b26) translation by microRNA specifically expressed in female mouse submandibular glands: an additional mechanism for sexual dimorphism of klk1b26 protein in the glands

Biology of Sex Differences, 2011
Background Mouse kallikrein 1b26 (klk1b26) protein is more abundant in male submandibular glands (SMGs) than in female ones. This sexual dimorphism has been thought to be due to increased mRNA synthesis stimulated by androgen.
Kurihara Kinji, Nakanishi Nobuo, Tomomura Akito   +2 more
doaj   +1 more source

Drugging the undruggable: activity-based protein profiling offers opportunities for targeting the KLK activome

Cancer Biology & Therapy, 2022
The vast majority of the human proteome is yet to be functionally characterized thus hindering ongoing investigations on potential drug resistance mechanisms and advanced treatment options.
Kristi Y. Lee, Cindy H. Chau, Douglas K. Price, William D. Figg   +3 more
doaj   +1 more source

Alzheimer’s Disease: In Vitro and In Vivo Evidence of Activation of the Plasma Bradykinin-Forming Cascade and Implications for Therapy

Cells
The plaques associated with Alzheimer’s disease are formed as a result of the aggregation of Aβ peptides, which vary in length from 38 to 43 amino acids.
Allen P. Kaplan, Berhane Ghebrehiwet, Kusumam Joseph   +2 more
doaj   +1 more source