Results 41 to 50 of about 30,372 (240)

Drugging the undruggable: activity-based protein profiling offers opportunities for targeting the KLK activome

Cancer Biology & Therapy, 2022
The vast majority of the human proteome is yet to be functionally characterized thus hindering ongoing investigations on potential drug resistance mechanisms and advanced treatment options.
Kristi Y. Lee, Cindy H. Chau, Douglas K. Price, William D. Figg   +3 more
doaj   +1 more source

Inhibitor regulation of tissue kallikrein activity in the synovial fluid of patients with rheumatoid athritis [PDF]

, 1994
Tissue kallikrein (TK) and 1-antitrypsin (AT)/TK complexes can be detected in SF from patients with RA if components of the fluids which interfere with the detection of TK are removed.
Bhoola, K. D., Elson, C. J., Dieppe, P. A., Worthy, K., Rahman, M. M., Fink, Edwin   +5 more
core   +1 more source

Alzheimer’s Disease: In Vitro and In Vivo Evidence of Activation of the Plasma Bradykinin-Forming Cascade and Implications for Therapy

Cells
The plaques associated with Alzheimer’s disease are formed as a result of the aggregation of Aβ peptides, which vary in length from 38 to 43 amino acids.
Allen P. Kaplan, Berhane Ghebrehiwet, Kusumam Joseph   +2 more
doaj   +1 more source

Serum proteases prevent bacterial biofilm formation: role of kallikrein and plasmin

Virulence, 2021
Biofilm formation is a general strategy for bacterial pathogens to withstand host defense mechanisms. In this study, we found that serum proteases inhibit biofilm formation by Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, and ...
Jesús Arenas, Zalan Szabo, Jelle van der Wal, Coen Maas, Tahira Riaz, Tone Tønjum, Jan Tommassen   +6 more
doaj   +1 more source

Investigation of a Serine Protease Inhibitor Active in the Infectious Stage of the Human Liver Fluke Opisthorchis viverrini

Pathogens
Serine protease inhibitors (serpins) participate in the regulation of inflammation, blood coagulation, and complement activation in humans. This research aimed to identify and characterize such inhibitors of the human liver fluke Opisthorchis viverrini ...
Rosnanee Salang, Wansika Phadungsil, Amornrat Geadkaew-Krenc, Rudi Grams   +3 more
doaj   +1 more source

Kallikrein-like amidase activity in renal ischemia and reperfusion

Brazilian Journal of Medical and Biological Research, 2000
We assessed a kallikrein-like amidase activity probably related to the kallikrein-kinin system, as well as the participation of leukocyte infiltration in renal ischemia and reperfusion.
M.D. Carattino, F. Cueva, T.M. Fonovich-de-Schroeder, A. Zuccollo   +3 more
doaj   +1 more source

Activity of kallikrein-kinin system in children in norm and at some pathological states

Бюллетень сибирской медицины, 2009
Proteolytic systems of tissue and blood plasma take part in the processes of adaptation and protection of an organism, as well as in development of pathological reactions.
Ye. I. Kondratiyeva, T. Ye. Tropova, G. A. Sukhanova, A. A. Terentiyeva, T. S. Krivonogova, V. V. Gorev, N. P. Stepanenko, Ye. Yu. Tyuteva   +7 more
doaj   +1 more source

FEATURES KALLIKREIN-KININ SYSTEMS AND DYSFUNCTIONS ENDOTHELIUM AT NEWBORNS WITH HYPOXEMIC DEFEAT OF THE CENTRAL NERVOUS SYSTEM

Бюллетень сибирской медицины, 2013
Proteolytic systems of tissue and blood plasma take part in the processes of adaptation and protection of an organism, as well as in development of pathological reactions.
V. A. Zhelev, A. S. Pogudina, V. V. Gorev   +2 more
doaj   +1 more source

Human Tissue Kallikreins-Related Peptidases Are Targets for the Treatment of Skin Desquamation Diseases

Frontiers in Medicine, 2022
Human tissue Kallikrein-related peptidases (hKLKs) are serine proteases distributed in several tissues that are involved in several biological processes.
Marcelo B. Zani, Aquiles M. Sant'Ana, Rafael C. Tognato, Jair R. Chagas, Luciano Puzer   +4 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source