Results 61 to 70 of about 38,460 (214)

Protease: Serpin complexes to assess contact system and intrinsic pathway activation

Research and Practice in Thrombosis and Haemostasis, 2020
Mounting evidence suggests that a variety of disease states are pathophysiologically related to activation of the contact system in vivo. The plasma contact system is composed of a cascade of serine proteases initiated by surface activation of factor XII,
Michael W. Henderson, Denis F. Noubouossie, Anton Ilich, Kathy J. Wilson, Rafal Pawlinski, Dougald M. Monroe, Nigel S. Key   +6 more
doaj   +1 more source

Kallikrein inhibitors.

Federation proceedings, 1979
So far the Cl inactivator, alpha 2-macroglobulin, antithrombin III (in the presence of heparin), and alpha 1-antitrypsin have been identified as inhibitors of plasma kallikrein; alpha 1-antitrypsin reacts slowly also with tissue kallikreins. Of the various naturally occurring kallikrein inhibitors the basic trypsin-kallikrein inhibitor of bovine organs,
Fritz, Hans, Fink, Edwin, Truscheit, Ernst   +2 more
openaire   +2 more sources

Predictive Value of Four Kallikrein Markers for Pathologically Insignificant Compared With Aggressive Prostate Cancer in Radical Prostatectomy Specimens: Results From the European Randomized Study of Screening for Prostate Cancer Section Rotterdam

European Urology, 2013
Background Treatment decisions can be difficult in men with low-risk prostate cancer (PCa). Objective To evaluate the ability of a panel of four kallikrein markers in blood—total prostate-specific antigen (PSA), free PSA, intact PSA, and kallikrein ...
S. Carlsson, A. Maschino, F. Schröder, C. Bangma, E. Steyerberg, T. H. van der Kwast, G. V. van Leenders, A. Vickers, H. Lilja, M. Roobol   +9 more
semanticscholar   +1 more source

Influence of “mild” stress on the level of biochemical markers of pathology in the submandibular glands of rats

Journal of Education, Health and Sport
Background. Stress is one of the important causes of the development of pathological processes in the body. The salivary glands play a certain role in the pathogenesis of post-stress pathological reactions Aim.
Ya. Yuzkiv
doaj   +1 more source

Cleavage Activation of Human-adapted Influenza Virus Subtypes by Kallikrein-related Peptidases 5 and 12*

Journal of Biological Chemistry, 2013
Background: Cleavage of the influenza HA precursor by host proteases is a critical step in the virus life cycle. Results: The airway-secreted proteases kallikrein 5 and kallikrein 12 were found to cleave and activate influenza HA.
B. S. Hamilton, G. Whittaker
semanticscholar   +1 more source

Prostate Specific Kallikrein-related Peptidases and Their Relation to Prostate Cancer Biology and Detection; Established Relevance and Emerging Roles

Thrombosis and Haemostasis, 2013
summary Kallikreins are a family of serine proteases with a range of tissue-specific and essential proteolytic functions. Among the best studied are the prostate tissue-specific KLK2 and KLK3 genes and their secreted protease products, human kallikrein 2,
Daniel L. J. Thorek, M. Evans, S. Carlsson, D. Ulmert, H. Lilja   +4 more
semanticscholar   +1 more source

Modulation of the Plasma Kallikrein-Kinin System Proteins Performed by Heparan Sulfate Proteoglycans

Frontiers in Physiology, 2017
Human plasma kallikrein-kinin system proteins are related to inflammation through bradykinin. In the proximity of its target cells, high molecular weight kininogen (H-kininogen) is the substrate of plasma kallikrein, which releases bradykinin from H ...
Guacyara Motta, Ivarne L. S. Tersariol
doaj   +1 more source

Thromboinflammatory complications of Bothrops snakebite envenoming: the case of B. lanceolatus endemic to the Caribbean Island of Martinique

Frontiers in Immunology
Snakebite envenoming remains a predominant neglected disease in tropical and subtropical regions, with high rates of morbidity and mortality worldwide. Bothrops snakebite envenoming.
Caroline Rapon, Jonathan Florentin, Jonathan Florentin, Fatima Radouani, Fatima Radouani, Prisca Jalta, Prisca Jalta, Florian Negrello, Florian Negrello, Papa Gueye, Papa Gueye, Olivier Pierre-Louis, Remi Neviere, Dabor Resiere, Dabor Resiere   +14 more
doaj   +1 more source

Kallikreins [PDF]

Biochemical Journal, 1969
E, Werle, F, Fiedler
openaire   +2 more sources

Kallikrein Cascades in Traumatic Spinal Cord Injury: In Vitro Evidence for Roles in Axonopathy and Neuron Degeneration

Journal of Neuropathology and Experimental Neurology, 2013
Kallikreins (KLKs) are a family of 15 secreted serine proteases with emerging roles in neurological disease. To illuminate their contributions to the pathophysiology of spinal cord injury (SCI) we evaluated acute through chronic changes in the ...
M. Radulović, Hyesook Yoon, Nadya Larson, Jianmin Wu, Rachel Linbo, J. Burda, E. Diamandis, S. Blaber, M. Blaber, M. Fehlings, I. Scarisbrick   +10 more
semanticscholar   +1 more source