Results 51 to 60 of about 38,460 (214)
Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome
Journal of Experimental Medicine, 2014 Elevated kallikrein 5 expression is sufficient to trigger the majority of the clinical hallmarks of Netherton syndrome.
L. Furio +6 more
semanticscholar +1 more source
Kallikrein immobilized on magnetic beads for activity-based assays using mass spectrometry
Frontiers in Analytical ScienceA crucial step in drug discovery involves identifying active molecules, which depends on fast and efficient screening assay methods. Kallikreins a family of serine protease enzymes, play a pivotal role in biological fluids and tissues.
Camila Loreta Rocha +1 more
doaj +1 more source
Kinins and Kinin Receptors in Cardiovascular and Renal Diseases
Pharmaceuticals, 2021 This review addresses the physiological role of the kallikrein–kinin system in arteries, heart and kidney and the consequences of kallikrein and kinin actions in diseases affecting these organs, especially ischemic and diabetic diseases.
Jean-Pierre Girolami +3 more
doaj +1 more source
Activity of kallikrein-kinin system at patients with asiderotic anemia
Бюллетень сибирской медицины, 2004 The aim of investigation is to study the state of kallikrein-kinin system (KKS) and proteinase inhibitors at patients with asiderotic anemia prior to and after the treatment. 58 patients with asiderotic anemia prior to the treatment and in dynamics after
N. N. Zhilkova
doaj +1 more source
Journal of Experimental Medicine, 2009 Netherton syndrome (NS) is a severe genetic skin disease with constant atopic manifestations that is caused by mutations in the serine protease inhibitor Kazal-type 5 (SPINK5) gene, which encodes the protease inhibitor lymphoepithelial Kazal-type–related
Anaïs Briot +7 more
semanticscholar +1 more source
Kallikreins and lupus nephritis [PDF]
Journal of Clinical Investigation, 2009 The kidney kallikrein-kinin system plays important roles in inflammation, coagulation, angiogenesis, and regulation of vessel tone and permeability. In this issue of the JCI, Liu et al. provide data that suggest a protective role for kallikrein in animal models of anti-glomerular basement membrane(GBM) antibody-induced nephritis, an experimental model ...
C. Ponticelli, P. Meroni
openaire +2 more sources
Brazilian Journal of Medical and Biological Research, 2000 We have shown that tissue-type plasminogen activator (tPA) and plasma kallikrein share a common pathway for liver clearance and that the hepatic clearance rate of plasma kallikrein increases during the acute-phase (AP) response.
M.R. Nagaoka +2 more
doaj +1 more source
Biomedicines(1) Background: This cross-sectional investigation appreciated the role of serum C-reactive protein (CRP), several hematologic-cell markers, and salivary inflammation-related molecules [calprotectin (S100A8/A9), interleukin-1β (IL-1β), kallikrein] to ...
Carmen Silvia Caloian +11 more
doaj +1 more source
Vaspin inhibits kallikrein 7 by serpin mechanism
Cellular and Molecular Life Sciences, 2013 The molecular target of the adipokine vaspin (visceral adipose tissue-derived serpin; serpinA12) and its mode of action are unknown. Here, we provide the vaspin crystal structure and identify human kallikrein 7 (hK7) as a first protease target of vaspin ...
J. Heiker +9 more
semanticscholar +1 more source
Towards understanding the kallikrein-kinin system: insights from measurement of kinin peptides
Brazilian Journal of Medical and Biological Research, 2000 The kallikrein-kinin system is complex, with several bioactive peptides that are formed in many different compartments. Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium ...
D.J. Campbell
doaj +1 more source