Results 51 to 60 of about 30,372 (240)
Renal and vascular effects of kallikrein inhibition in a model of Lonomia obliqua venom-induced acute kidney injury. [PDF]
PLoS Neglected Tropical Diseases, 2019 BACKGROUND:Lonomia obliqua venom is nephrotoxic and acute kidney injury (AKI) is the main cause of death among envenomed victims. Mechanism underlying L.
Markus Berger +10 more
doaj +1 more source
Advanced Science, EarlyView.We report a chromogenic release‐based assay system with protease‐cleavage peptide‐modified calcium carbonate microspheres for colorimetric detection of Porphyromonas (P.) gingivalis activity. In response to Arg‐specific gingipain secreted by P. gingivalis, the supernatant becomes colored, enabling colorimetric analysis and providing the monitoring of ...
Yuki Hiruta +9 more
wiley +1 more source
Role of Serine Proteases at the Tumor-Stroma Interface
Frontiers in Immunology, 2022 During tumor development, invasion and metastasis, the intimate interaction between tumor and stroma shapes the tumor microenvironment and dictates the fate of tumor cells.
Ravichandra Tagirasa, Euna Yoo
doaj +1 more source
Advanced Science, EarlyView.SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang +9 more
wiley +1 more source
A Missing Link Between a High Salt Intake and Blood Pressure Increase
Journal of Pharmacological Sciences, 2006 .: It is widely accepted that a high sodium intake triggers blood pressure rise. However, only one-third of the normotensive subjects were reported to show salt-sensitivity in their blood pressure.
Makoto Katori, Masataka Majima
doaj +1 more source
Advanced Science, EarlyView.By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo +15 more
wiley +1 more source
The complex role of kininogens in hereditary angioedema
Frontiers in Allergy, 2022 Human high molecular weight kininogen (HK) is the substrate from which bradykinin is released as a result of activation of the plasma “contact” system, a cascade that includes the intrinsic coagulation pathway, and a fibrinolytic pathway leading to the ...
Allen P. Kaplan +2 more
doaj +1 more source
The hyaluronan-binding serine protease from human plasma cleaves HMW and LMW kininogen and releases bradykinin [PDF]
, 2002 The influence of the hyaluronanbinding protease (PHBSP), a plasma enzyme with FVII- and pro-urokinase-activating potency, on components of the contact phase (kallikrein/kinin) system was investigated.
Fink, E. +4 more
core +1 more source
Mechanisms involved in hereditary angioedema with normal C1-inhibitor activity
Frontiers in Physiology, 2023 Patients with the inherited disorder hereditary angioedema (HAE) suffer from episodes of soft tissue swelling due to excessive bradykinin production.
Aleksandr Shamanaev +9 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim Ceftriaxone is a cephalosporin commonly used for the treatment of acute, severe infections; however, there are conflicting data on its disposition properties in children, making it a suitable case study for the evaluation of the appropriateness of extrapolation approaches based on exposure matching principles for paediatric patients and exploring ...
Daniel Valente Neves +7 more
wiley +1 more source