Results 31 to 40 of about 38,460 (214)

Serum proteases prevent bacterial biofilm formation: role of kallikrein and plasmin

Virulence, 2021
Biofilm formation is a general strategy for bacterial pathogens to withstand host defense mechanisms. In this study, we found that serum proteases inhibit biofilm formation by Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, and ...
Jesús Arenas, Zalan Szabo, Jelle van der Wal, Coen Maas, Tahira Riaz, Tone Tønjum, Jan Tommassen   +6 more
doaj   +1 more source

Plasma Kallikrein Mediates Vascular Endothelial Growth Factor–Induced Retinal Dysfunction and Thickening

Investigative Ophthalmology and Visual Science, 2016
Purpose Plasma kallikrein is a serine protease and circulating component of inflammation, which exerts clinically significant effects on vasogenic edema. This study examines the role of plasma kallikrein in VEGF-induced retinal edema.
A. Clermont, Nivetha Murugesan, Qunfang Zhou, T. Kita, P. Robson, Louise J. Rushbrooke, D. Michael Evans, L. P. Aiello, E. Feener   +8 more
semanticscholar   +1 more source

Investigation of a Serine Protease Inhibitor Active in the Infectious Stage of the Human Liver Fluke Opisthorchis viverrini

Pathogens
Serine protease inhibitors (serpins) participate in the regulation of inflammation, blood coagulation, and complement activation in humans. This research aimed to identify and characterize such inhibitors of the human liver fluke Opisthorchis viverrini ...
Rosnanee Salang, Wansika Phadungsil, Amornrat Geadkaew-Krenc, Rudi Grams   +3 more
doaj   +1 more source

Kallikrein-like amidase activity in renal ischemia and reperfusion

Brazilian Journal of Medical and Biological Research, 2000
We assessed a kallikrein-like amidase activity probably related to the kallikrein-kinin system, as well as the participation of leukocyte infiltration in renal ischemia and reperfusion.
M.D. Carattino, F. Cueva, T.M. Fonovich-de-Schroeder, A. Zuccollo   +3 more
doaj   +1 more source

Predicting High-Grade Cancer at Ten-Core Prostate Biopsy Using Four Kallikrein Markers Measured in Blood in the ProtecT Study

Journal of the National Cancer Institute, 2015
Background: Many men with elevated prostate-specific antigen (PSA) levels in serum do not have aggressive prostate cancer and undergo unnecessary biopsy.
R. Bryant, D. Sjoberg, A. Vickers, M. Robinson, R. Kumar, L. Marsden, M. Davis, P. Scardino, J. Donovan, D. Neal, H. Lilja, F. Hamdy   +11 more
semanticscholar   +1 more source

Activity of kallikrein-kinin system in children in norm and at some pathological states

Бюллетень сибирской медицины, 2009
Proteolytic systems of tissue and blood plasma take part in the processes of adaptation and protection of an organism, as well as in development of pathological reactions.
Ye. I. Kondratiyeva, T. Ye. Tropova, G. A. Sukhanova, A. A. Terentiyeva, T. S. Krivonogova, V. V. Gorev, N. P. Stepanenko, Ye. Yu. Tyuteva   +7 more
doaj   +1 more source

Improving the Specificity of Screening for Lethal Prostate Cancer Using Prostate-specific Antigen and a Panel of Kallikrein Markers: A Nested Case–Control Study

European Urology, 2015
Background A disadvantage of prostate-specific antigen (PSA) for the early detection of prostate cancer (PCa) is that many men must be screened, biopsied, and diagnosed to prevent one death.
P. Stattin, A. Vickers, D. Sjoberg, R. Johansson, T. Granfors, M. Johansson, K. Pettersson, P. Scardino, G. Hallmans, H. Lilja   +9 more
semanticscholar   +1 more source

FEATURES KALLIKREIN-KININ SYSTEMS AND DYSFUNCTIONS ENDOTHELIUM AT NEWBORNS WITH HYPOXEMIC DEFEAT OF THE CENTRAL NERVOUS SYSTEM

Бюллетень сибирской медицины, 2013
Proteolytic systems of tissue and blood plasma take part in the processes of adaptation and protection of an organism, as well as in development of pathological reactions.
V. A. Zhelev, A. S. Pogudina, V. V. Gorev   +2 more
doaj   +1 more source

Human Tissue Kallikreins-Related Peptidases Are Targets for the Treatment of Skin Desquamation Diseases

Frontiers in Medicine, 2022
Human tissue Kallikrein-related peptidases (hKLKs) are serine proteases distributed in several tissues that are involved in several biological processes.
Marcelo B. Zani, Aquiles M. Sant'Ana, Rafael C. Tognato, Jair R. Chagas, Luciano Puzer   +4 more
doaj   +1 more source

A Four-kallikrein Panel Predicts High-grade Cancer on Biopsy: Independent Validation in a Community Cohort

European Urology, 2015
Background A statistical model based on four kallikrein markers (total prostate-specific antigen [tPSA], free PSA [fPSA], intact PSA, and human kallikrein-related peptidase 2) in blood can predict risk of Gleason score ≥7 (high-grade) cancer at prostate ...
K. Braun, D. Sjoberg, A. Vickers, H. Lilja, A. Bjartell   +4 more
semanticscholar   +1 more source