Results 31 to 40 of about 30,372 (240)
Expression of kallikrein-related peptidase 7 is decreased in prostate cancer
Asian Journal of Andrology, 2015 Recent evidence suggests that the human kallikrein 7 (KLK7) is differentially regulated in a variety of tumors. The aim of this study was to determine the expression of kallikrein-related peptidase 7 and KLK7 in our large collection of prostate samples ...
Chong-Yu Zhang +4 more
doaj +1 more source
Not more than three tissue kallikreins identified from organs of the guinea pig [PDF]
, 1999 The large and varied multigene families of tissue kallikreins of rat and mouse are considered to selectively release as many bioactive peptides. In order to determine whether a similar family of enzymes is expressed in the organs of the guinea pig ...
Fiedler, F. +5 more
core +1 more source
Inhibition of Plasma Kallikrein with Aprotinin in porcine endotoxin Shock [PDF]
, 1993 Activation of the contact phase of coagulation has been implicated in the pathogenesis of septic shock. We wanted to determine if inhibition of plasma kallikrein can prevent arterial hypotension and liberation of kinins from kininogen, induced by an ...
Siebeck, Matthias +8 more
core +1 more source
Dextran sulfate activates contact system and mediates arterial hypotension via B2 kinin receptors [PDF]
, 1994 To define some of the mechanisms underlying dextran sulfate (DXS)-induced hypotension, we investigated the effects of either the plasma kallikrein inhibitor des-Pro2-[Arg15] aprotinin (BAY x 4620) or the specific bradykinin B2-receptor antagonist Hoe-140
Cheronis, J. C. +16 more
core +2 more sources
Stem Cells International, 2018 Delayed administration of kallikrein after cerebral infarction can improve neurological function. However, the appropriate kallkrein treatment time after ischemic stroke has not been illuminated.
Yaohui Ni +7 more
doaj +1 more source
Visualisation of tissue kallikrein, kininogen and kinin receptors in human skin following trauma and in dermal diseases [PDF]
, 2004 During dermal injury and inflammation the serine proteases kallikreins cleave endogenous, multifunctional substrates (kininogens) to form bradykinin and kallidin.
Valeske, Klaus +15 more
core +1 more source
Angewandte Chemie, EarlyView.Chemical peptide synthesis allows the generation of structurally highly diverse compounds suited for ligand development, but current methods in parallel peptide synthesis limit the achievable library size to a few thousand. A strategy is presented based on combinatorial pairing of short peptides via disulfide linkage that enables the generation and ...
Anne Zarda +5 more
wiley +2 more sources
Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond
Frontiers in Physiology, 2023 Human plasma kallikrein (PKa) is obtained by activating its precursor, prekallikrein (PK), historically named the Fletcher factor. Human PKa and tissue kallikreins are serine proteases from the same family, having high- and low-molecular weight ...
Guacyara Motta +2 more
doaj +1 more source
Drugs and Drug CandidatesChronic kidney disease (CKD) has emerged as a pervasive global health concern, for which there are no known curative treatments. Consequently, there is an imperative for the implementation of preventive and kidney-protective strategies.
Leopoldo Ardiles, Carlos D. Figueroa
doaj +1 more source
Biology of Sex Differences, 2011 Background Mouse kallikrein 1b26 (klk1b26) protein is more abundant in male submandibular glands (SMGs) than in female ones. This sexual dimorphism has been thought to be due to increased mRNA synthesis stimulated by androgen.
Kurihara Kinji +2 more
doaj +1 more source