Results 1 to 10 of about 74,387 (246)

Bradykinin reduces wound healing in human umbilical vein endothelial cells via downregulation of vascular endothelial growth factor A [PDF]

Journal of Inflammation
Introduction Hereditary angioedema (HAE) is characterized by acute swelling attacks triggered by abnormally elevated levels of bradykinin. Despite persistently high bradykinin levels, patients experience only intermittent swelling episodes.
Nevena Dimitrova, Angelina Gierke, Raphael Möhrle, Julia Nemeth, Cornelia Brunner, Thomas K. Hoffmann, Jens Greve, Janina Hahn, Robin Lochbaum   +8 more
doaj   +2 more sources

Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice

Nature Communications, 2023
An important role for liver in the regulation of adipose tissue thermogenesis upon cold exposure has been suggested; however, the underlying mechanisms remain incompletely defined.
Fei Xiao, Haizhou Jiang, Zi Li, Xiaoxue Jiang, Shanghai Chen, Yuguo Niu, Hanrui Yin, Yousheng Shu, Bo Peng, Wei Lu, Xiaoying Li, Zhigang Li, Shujue Lan, Xiaoyan Xu, Feifan Guo   +14 more
doaj   +1 more source

The des-Arg9-bradykinin/B1R axis: Hepatic damage in COVID-19

Frontiers in Physiology, 2022
Patients infected by the SARS-CoV-2 virus are commonly diagnosed with threatening liver conditions associated with drug-induced therapies and systemic viral action.
Gabriel Moreira de M Mendes, Gabriel Moreira de M Mendes, Israel Júnior Borges Do Nascimento, Israel Júnior Borges Do Nascimento, Paulo HS. Marazzi-Diniz, Izabela B. Da Silveira, Izabela B. Da Silveira, Matheus F. Itaborahy, Matheus F. Itaborahy, Luiz E. Viana, Luiz E. Viana, Filipe A. Silva, Monique F Santana, Rebecca AA. Pinto, Bruna G. Dutra, Marcus Vinicius G. Lacerda, Stanley A. Araujo, David Wanderley, Paula VT. Vidigal, Paulo HC Diniz, Thiago Verano-Braga, Robson AS. Santos, M Fatima Leite   +22 more
doaj   +1 more source

Bradykinin-induced angioedema in the emergency department

International Journal of Emergency Medicine, 2022
Background Acute airway angioedema commonly occurs through two distinct mechanisms: histamine- and bradykinin-dependent. Although they respond to distinct treatments, these two potentially life-threatening states present similarly.
Jacques Hébert, Jean-Nicolas Boursiquot, Hugo Chapdelaine, Benoit Laramée, Marylin Desjardins, Rémi Gagnon, Nancy Payette, Oleksandra Lepeshkina, Matthieu Vincent   +8 more
doaj   +1 more source

Kinin-B2 receptor mediated neuroprotection after NMDA excitotoxicity is reversed in the presence of kinin-B1 receptor agonists. [PDF]

PLoS ONE, 2012
Kinins, with bradykinin and des-Arg(9)-bradykinin being the most important ones, are pro-inflammatory peptides released after tissue injury including stroke.
Antonio H Martins, Janaina M Alves, Dinely Perez, Marimeé Carrasco, Wilmarie Torres-Rivera, Vesna A Eterović, Pedro A Ferchmin, Henning Ulrich   +7 more
doaj   +1 more source

Increased plasma bradykinin level is associated with cognitive impairment in Alzheimer's patients

Neurobiology of Disease, 2020
Alzheimer's disease (AD) is characterized by the presence of proteinaceous brain deposits, brain atrophy, vascular dysfunction, and chronic inflammation.
Pradeep K. Singh, Zu-Lin Chen, Dhiman Ghosh, Sidney Strickland, Erin H. Norris   +4 more
doaj   +1 more source

Sensitive mass spectrometric determination of kinin-kallikrein system peptides in light of COVID-19

Scientific Reports, 2021
The outbreak of COVID-19 has raised interest in the kinin–kallikrein system. Viral blockade of the angiotensin-converting enzyme 2 impedes degradation of the active kinin des-Arg(9)-bradykinin, which thus increasingly activates bradykinin receptors known
Tanja Gangnus, Bjoern B. Burckhardt
doaj   +1 more source

The Bradykinin System Contributes to the Regulation of Prostaglandin-Endoperoxide Synthase 2 Expression in Human Amnion Fibroblasts: Implications for Term and Preterm Birth

Frontiers in Endocrinology, 2022
BackgroundBradykinin (BK) and its biologically active metabolite des-Arg9 bradykinin (DABK) play a pivotal role in inflammation. Since chorioamnionitis is the leading cause of preterm birth and prostaglandin E2 (PGE2) derived from the amnion is key to ...
Xiao-tian Ni, Wang-sheng Wang, Wang-sheng Wang, Yun Liu, Yi-kai Lin, Yi-kai Lin, Fan Zhang, Fan Zhang, Wen-jia Lei, Wen-jia Lei, Li-jun Ling, Fan Pan, Fan Pan, Ya-nan Zhu, Ya-nan Zhu, Meng-die Li, Meng-die Li, Tao Duan, Ming Liu, Kang Sun, Kang Sun   +20 more
doaj   +1 more source

Different Prostanoids Are Involved in Bradykinin-Induced Endothelium-Dependent and -Independent Vasoconstriction in Rat Mesenteric Resistance Arteries

Journal of Pharmacological Sciences, 2004
Mechanisms underlying bradykinin-induced vasoconstriction were investigated in rat perfused mesenteric vascular beds with active tone. In preparations with intact endothelium, bolus injections of bradykinin (1 to 1,000 pmol) dose-dependently produced ...
Hideki Nawa, Yuji Kurosaki, Hiromu Kawasaki   +2 more
doaj   +1 more source

Dysregulated Bradykinin: Mystery in the Pathogenesis of COVID-19

Mediators of Inflammation, 2022
The COVID-19 pandemic is rapidly spreading, and health care systems are being overwhelmed with the huge number of cases, with a good number of cases requiring intensive care.
Aisha Tabassum, Mohammad Shahid Iqbal, Sadia Sultan, Raghad Ali Alhuthali, Deena Ismail Alshubaili, Raghad Salah Sayyam, Lama Mohammed Abyad, Ahmed H. Qasem, Ahmad F. Arbaeen   +8 more
doaj   +1 more source