Results 11 to 20 of about 38,460 (214)

Molecular biology of the kallikrein-kinin system: from structure to function

Brazilian Journal of Medical and Biological Research, 1998
The participation of the kallikrein-kinin system, comprising the serine proteases kallikreins, the protein substrates kininogens and the effective peptides kinins, in some pathological processes like hypertension and cardiovascular diseases is still a ...
J.B. Pesquero, M. Bader
doaj   +1 more source

New tools to study contact activation.

Frontiers in Medicine, 2016
The recent availability of a sensitive chromogenic method approach for determination of FXIa activity has been explored for designing sensitive methods for FXIIa and Kallikrein, both using FXa formation as the read-out. For both enzymes the assay range 1-
Steffen Rosén
doaj   +1 more source

Pancreatic kallikrein protects against diabetic retinopathy in KK Cg-Ay/J and high-fat diet/streptozotocin-induced mouse models of type 2 diabetes

Diabetologia, 2019
Aims/hypothesisMany studies have shown that tissue kallikrein has effects on diabetic vascular complications such as nephropathy, cardiomyopathy and neuropathy, but its effects on diabetic retinopathy are not fully understood.
Ying Cheng, Xiaochen Yu, Jie Zhang, Yun-peng Chang, Mei Xue, Xiaoyu Li, Yun-hong Lu, Ting Li, Ziyu Meng, Long Su, Bei Sun, Liming Chen   +11 more
semanticscholar   +1 more source

Potassium Intake Prevents the Induction of the Renin-Angiotensin System and Increases Medullary ACE2 and COX-2 in the Kidneys of Angiotensin II-Dependent Hypertensive Rats

Frontiers in Pharmacology, 2019
In angiotensin II (Ang II)-dependent hypertensive rats there is an increased expression of proximal tubule angiotensinogen (AGT), collecting duct renin and angiotensin converting enzyme (ACE), which contributes to intratubular Ang II formation.
Alexis A. Gonzalez, Matias Gallardo, Carlos Cespedes, Carlos Cespedes, Carlos P. Vio, Carlos P. Vio   +5 more
doaj   +1 more source

Contact pathway in surgical and transcatheter aortic valve replacement

Frontiers in Cardiovascular Medicine, 2022
BackgroundAortic valve replacement is the gold standard treatment for severe symptomatic aortic stenosis, but thrombosis of bioprosthetic valves (PVT) remains a concern.ObjectiveTo analyze the factors involved in the contact pathway during aortic valve ...
María Eugenia de la Morena-Barrio, Javier Corral, Cecilia López-García, Víctor Alonso Jiménez-Díaz, Antonia Miñano, Pablo Juan-Salvadores, María Asunción Esteve-Pastor, José Antonio Baz-Alonso, Ana María Rubio, Francisco Sarabia-Tirado, Miguel García-Navarro, Juan García-Lara, Francisco Marín, Vicente Vicente, Eduardo Pinar, Sergio José Cánovas, Gonzalo de la Morena   +16 more
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Kallikrein Cleaves C3 and Activates Complement

Journal of Innate Immunity, 2017
The human plasma contact system is an immune surveillance system activated by the negatively charged surfaces of bacteria and fungi and includes the kallikrein-kinin, the coagulation, and the fibrinolytic systems.
Sarah Irmscher, N. Döring, L. D. Halder, Emeraldo A. H. Jo, I. Kopka, Christine Dunker, I. Jacobsen, Shanshan Luo, H. Slevogt, S. Lorkowski, N. Beyersdorf, P. Zipfel, C. Skerka   +12 more
semanticscholar   +1 more source

Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary Angioedema

New England Journal of Medicine, 2018
Background Hereditary angioedema is a life‐threatening illness caused by mutations in the gene encoding C1 inhibitor (also called C1 esterase inhibitor) that lead to overactivation of the kallikrein–bradykinin cascade.
E. Aygören‐Pürsün, A. Bygum, V. Grivcheva-Panovska, M. Magerl, J. Graff, U. Steiner, O. Fain, A. Huissoon, T. Kinaciyan, H. Farkas, R. Lleonart, H. Longhurst, W. Rae, M. Triggiani, W. Aberer, M. Cancian, A. Zanichelli, William B Smith, M. Baeza, A. Du-Thanh, M. Gompels, T. González-Quevedo, J. Greve, M. Guilarte, C. Katelaris, S. Dobo, M. Cornpropst, D. Clemons, L. Fang, P. Collis, W. Sheridan, M. Maurer, M. Cicardi   +32 more
semanticscholar   +1 more source

Cleavage of the vaspin N-terminus releases cell-penetrating peptides that affect early stages of adipogenesis and inhibit lipolysis in mature adipocytes

Adipocyte, 2021
Vaspin expression and function is related to metabolic disorders and comorbidities of obesity. In various cellular and animal models of obesity, diabetes and atherosclerosis vaspin has shown beneficial, protective and/or compensatory action.
Catherine A. Tindall, Estelle Erkner, Jan Stichel, Annette G. Beck-Sickinger, Anne Hoffmann, Juliane Weiner, John T. Heiker   +6 more
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Stable and Long-Lasting, Novel Bicyclic Peptide Plasma Kallikrein Inhibitors for the Treatment of Diabetic Macular Edema.

Journal of Medicinal Chemistry, 2018
Plasma kallikrein, a member of the kallikrein-kinin system, catalyzes the release of the bioactive peptide bradykinin, which induces inflammation, vasodilation, vessel permeability, and pain.
D. Teufel, G. Bennett, H. Harrison, Katerine van Rietschoten, S. Pavan, Catherine Stace, François Le Floch, T. Van Bergen, Elke Vermassen, Philippe Barbeaux, T. Hu, J. Feyen, M. Vanhove   +12 more
semanticscholar   +1 more source

Expression of kallikrein-related peptidase 7 is decreased in prostate cancer

Asian Journal of Andrology, 2015
Recent evidence suggests that the human kallikrein 7 (KLK7) is differentially regulated in a variety of tumors. The aim of this study was to determine the expression of kallikrein-related peptidase 7 and KLK7 in our large collection of prostate samples ...
Chong-Yu Zhang, Yu Zhu, Wen-Bin Rui, Jun Dai, Zhou-Jun Shen   +4 more
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