Results 11 to 20 of about 30,372 (240)

The 3rd International Symposium on Kallikreins and Kallikrein-Related Peptidases [PDF]

Biological Chemistry, 2010
No abstract ...
Magdolen, Viktor, Schmitt, Manfred, Sommerhoff, Christian P., Fritz, Hans   +3 more
openaire   +5 more sources

Kallikrein inhibitors. [PDF]

Federation proceedings, 1979
So far the Cl inactivator, alpha 2-macroglobulin, antithrombin III (in the presence of heparin), and alpha 1-antitrypsin have been identified as inhibitors of plasma kallikrein; alpha 1-antitrypsin reacts slowly also with tissue kallikreins. Of the various naturally occurring kallikrein inhibitors the basic trypsin-kallikrein inhibitor of bovine organs,
Fritz, Hans, Fink, Edwin, Truscheit, Ernst   +2 more
core   +4 more sources

Reviewing clinical considerations and guideline recommendations of C1 inhibitor prophylaxis for hereditary angioedema

Clinical and Translational Allergy, 2022
Background Hereditary angioedema (HAE), a rare disease that is characterized by painful and recurring non‐allergic swelling episodes, is caused by the deficiency or dysfunction of C1 inhibitor (C1INH) protein.
John Anderson, Njeri Maina
doaj   +1 more source

Kallikrein‐1 Blockade Inhibits Aortic Expansion in a Mouse Model and Reduces Prostaglandin E2 Secretion From Human Aortic Aneurysm Explants

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. The kinin B2 receptor agonist, bradykinin, has been implicated in AAA pathogenesis through promoting inflammation.
Corey S. Moran, Erik Biros, Smriti M. Krishna, Susan K. Morton, Daniel J. Sexton, Jonathan Golledge   +5 more
doaj   +1 more source

Pathophysiological Response to SARS-CoV-2 Infection Detected by Infrared Spectroscopy Enables Rapid and Robust Saliva Screening for COVID-19

Biomedicines, 2022
Fourier transform infrared (FTIR) spectroscopy provides a (bio)chemical snapshot of the sample, and was recently used in proof-of-concept cohort studies for COVID-19 saliva screening.
Seth T. Kazmer, Gunter Hartel, Harley Robinson, Renee S. Richards, Kexin Yan, Sebastiaan J. van Hal, Raymond Chan, Andrew Hind, David Bradley, Fabian Zieschang, Daniel J. Rawle, Thuy T. Le, David W. Reid, Andreas Suhrbier, Michelle M. Hill   +14 more
doaj   +1 more source

Blood Kallikrein-8 and Non-Amnestic Mild Cognitive Impairment: An Exploratory Study

Journal of Alzheimer's Disease Reports, 2023
Background: Blood kallikrein-8 is supposed to be a biomarker for mild cognitive impairment (MCI) due to Alzheimer’s disease (AD), a precursor of AD dementia. Little is known about the association of kallikrein-8 and non-AD type dementias.
Sara Schramm, Nela Krizanovic, Ulla Roggenbuck, Karl-Heinz Jöckel, Arne Herring, Kathy Keyvani, Martha Jokisch   +6 more
doaj   +1 more source

The contact system proteases play disparate roles in streptococcal sepsis

Haematologica, 2020
Sepsis causes an activation of the human contact system, an inflammatory response mechanism against foreign surfaces, proteins and pathogens. The serine proteases of the contact system, factor XII and plasma kallikrein, are decreased in plasma of septic ...
Juliane Köhler, Claudia Maletzki, Dirk Koczan, Marcus Frank, Carolin Trepesch, Alexey S. Revenko, Jeffrey R. Crosby, A. Robert Macleod, Stefan Mikkat, Sonja Oehmcke-Hecht   +9 more
doaj   +1 more source

Lithium treatment reduces the renal kallikrein excretion rate [PDF]

, 1990
Lithium treatment reduces the renal kallikrein excretion rate. Lithium salts are widely used agents for the prophylactic treatment of affective disorders. Lithium salts may be associated with distal nephron dysfunction.
Marin-Grez, Marcos, Sauer, Heinrich, Gross, Peter, Reinhard, Caroline, Fink, Edwin   +4 more
core   +1 more source

Blocking domain 6 of high molecular weight kininogen to understand intrinsic clotting mechanisms

Research and Practice in Thrombosis and Haemostasis, 2022
Background The contact system is initiated by factor (F) XII activation and the assembly of high molecular weight kininogen (HK) with either FXI or prekallikrein (PK) on a negatively charged surface.
Pradeep K. Singh, Zu‐Lin Chen, Katharina Horn, Erin H. Norris   +3 more
doaj   +1 more source

A tissue kallikrein in the synovial fluid of patients with rheumatoid arthritis [PDF]

, 1989
Tissue kallikrein is an enzyme that forms the vasoactive peptide kallidin from an endogenous substrate L-kininogen. Tissue kallikrein has been identified in joint fluids and in inflammatory infiltrates within synovial membranes.
Bhoola, K. D., Selwyn, B. M., Dieppe, P. A., Figueroa, C. D., Swan, A., Fink, Edwin   +5 more
core   +1 more source