Results 1 to 10 of about 16,582 (161)

Kininogen enhances seizure susceptibility in mice possibly through bradykinin-induced modulation of calcium transients in glutamatergic and GABAergic neurons [PDF]

Frontiers in Pharmacology
BackgroundPreviously we showed that elevated cerebrospinal fluid (CSF) levels of kininogen during the acute phase of encephalitis are associated with symptomatic epilepsy.
Arijit Ghosh, Arijit Ghosh, Jiwen Huang, Jiwen Huang, Qian Wang, Qian Wang, Yanling Gong, Yanling Gong, Srishti Jain, Srishti Jain, Abhimanyu Thakur, Abhimanyu Thakur, Amiyangshu De, Amiyangshu De, Meixi Gong, Meixi Gong, Yoshie Kiyohara, Yoshie Kiyohara, Jingtai Hu, Lingyan Jin, Sharba Bandyopadhyay, Sharba Bandyopadhyay, Fang Chen, Shengtian Li   +23 more
doaj   +2 more sources

Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis

EBioMedicine, 2020
Background: High-molecular-weight kininogen is a cofactor of the human contact system, an inflammatory response mechanism that is activated during sepsis.
Bernd Kreikemeyer, Marcus Frank, Sonja Oehmcke-Hecht   +2 more
exaly   +3 more sources

Activated partial thromboplastin time prolongation without hemorrhagic dienhesis: a study of a chinese family coexisting with hereditary KNG1 p.Arg240 mutation and --SEA/αα genotype thalassemia [PDF]

Annals of Hematology
High molecular weight kininogen (HK) deficiency is a rare autosomal recessive disorder caused by mutations in the KNG1 gene. This study reports a 66-year-old male Chinese patient who presented with significantly prolonged activated partial thromboplastin
Zhiyao Bai, Jiayi Hu, Yanling Jin, Xiaodong Li, Jiqin Sun, Fan Zhang, Di Wu, Fengxiao Zhao, Ping Ji   +8 more
doaj   +2 more sources

Bacterial factors required for biofilm formation in Staphylococcus epidermidis are linked to contact activation [PDF]

Frontiers in Cellular and Infection Microbiology
Staphylococcus epidermidis is a leading cause of device-associated bloodstream infections, where biofilm formation contributes to persistence in direct contact with host plasma.
Annika Rademacher, Katharina Ekat, Romy Skusa, Lotte Scharnagl, Frederike Knipp, Christoph Warnke, Julia Marcinek, Selina Tobien, Marcus Frank, Marcus Frank, Valeria Khaimov, Holger Rohde, Bernd Kreikemeyer, Sonja Oehmcke-Hecht   +13 more
doaj   +2 more sources

Gene polymorphisms of miR-323b and miR-1343 that regulate kininogen L are associated with schizophrenia susceptibility: A preliminary population‑based study [PDF]

Biomolecules & Biomedicine
miR-SNP is a type of functional single nucleotide polymorphism (SNP) that affects the regulatory functions of miRNA genes, miRNA binding sites, or components of miRNA biogenesis.
Xiaoyu Liu, Mengdi Jin, Mingjia Yang, Lijuan Yan, Weijiao Zhao, Lizhuo Liu, Hongmin Wang, Yongzhuo Ding, Yanyan Sun, Yanchi Zhang, Qiong Yu   +10 more
doaj   +2 more sources

A novel assay of excess plasma kallikrein-kinin system activation in hereditary angioedema [PDF]

Frontiers in Allergy
BackgroundCleaved high-molecular-weight kininogen (HKa) is a disease state biomarker of kallikrein-kinin system (KKS) activation in patients with hereditary angioedema due to C1 inhibitor deficiency (HAE-C1INH), the endogenous inhibitor of plasma ...
Dan Sexton, Ryan Faucette, Melody Rivera-Hernandez, Jon A. Kenniston, Nikolaos Papaioannou, Janja Cosic, Kris Kopacz, Gary Salmon, Chantal Beauchemin, Salomé Juethner, Dave Yeung   +10 more
doaj   +2 more sources

Dextran sodium sulfate‐induced colitis in male BALB/c mice leads to albuminuria and increased markers of inflammation and tissue damage in the kidney [PDF]

Physiological Reports
Inflammatory molecules originating from an inflamed gut can promote systemic inflammation. We studied how acute intestinal injury affects the kidneys and the kallikrein‐kinin system in mice with dextran sodium sulfate (DSS)‐induced colitis.
Hanne Salmenkari, Krishna Adeshara, Anniina Pirttiniemi, Jere Lindén, Sanna Lehtonen, Niina Sandholm, Per‐Henrik Groop, Markku Lehto   +7 more
doaj   +2 more sources

Bradykinin release avoids high molecular weight kininogen endocytosis. [PDF]

PLoS ONE, 2015
Human H-kininogen (120 kDa) plays a role in many pathophysiological processes and interacts with the cell surface through protein receptors and proteoglycans, which mediate H-kininogen endocytosis.
Igor Z Damasceno, Katia R B Melo, Fabio D Nascimento, Daianne S P Souza, Mariana S Araujo, Sinval E G Souza, Misako U Sampaio, Helena B Nader, Ivarne L S Tersariol, Guacyara Motta   +9 more
doaj   +1 more source

Depressed Kallikrein Generation in Women With Preeclampsia: A Matched Cross-Sectional Study

Frontiers in Medicine, 2022
ObjectiveThe pathophysiology of preeclampsia is not fully understood. Disturbances in the contact system are associated with preeclampsia. Few studies have investigated the association between preeclampsia and alterations in the contact system in plasma.
Anne Cathrine Godtfredsen, Anne Cathrine Godtfredsen, Jørgen Brodersen Gram, Jørgen Brodersen Gram, Stephanie Thuy Duong Pham, Britta Blume Dolleris, Jan Stener Jørgensen, Johannes Jakobsen Sidelmann, Johannes Jakobsen Sidelmann, Yaseelan Palarasah, Yaseelan Palarasah   +10 more
doaj   +1 more source

Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond

Frontiers in Physiology, 2023
Human plasma kallikrein (PKa) is obtained by activating its precursor, prekallikrein (PK), historically named the Fletcher factor. Human PKa and tissue kallikreins are serine proteases from the same family, having high- and low-molecular weight ...
Guacyara Motta, Luiz Juliano, Jair Ribeiro Chagas   +2 more
doaj   +1 more source