Results 41 to 50 of about 17,108 (133)

Cathepsin L in cancer: Context‐dependent functions, microenvironmental regulation and translational opportunities

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Cathepsin L (CTSL) acts as a context‐dependent facilitator of tumour progression rather than a universal oncogenic driver. CTSL's pro‐tumorigenic functions are critically evaluated alongside its inherent biochemical constraints and family‐wide redundancy. CTSL‐related biology may provide translational opportunities in selected contexts.
Yujun Wu, Qin Huang, Zixuan Ding, Lin Fu, Mu Yang, Bi Peng, Pengbo Hu, Yuanhui Liu   +7 more
wiley   +1 more source

The effect of estrogen-containing birth control pills on the constituents of bradykinin expression in plasma

Journal of Allergy and Clinical Immunology: Global
Background: Hereditary angioedema with C1-inhibitor deficiency (HAE-C1INH) is a rare autosomal disorder presenting with recurrent angioedema. Estrogen-containing medications trigger angioedema in some patients, and conversely, progesterone may decrease ...
Janette M. Birmingham, MS, Juan Wisnivesky, MD, DrPH, Paula J. Busse, MD   +2 more
doaj   +1 more source

Normal thromboelastography with a markedly prolonged activated partial thromboplastin time in severe prekallikrein deficiency: Implications for perioperative hemostatic assessment

Transfusion, Volume 66, Issue 10, Page 2031-2036, October 2026.
Abstract Background Prekallikrein (PK) deficiency is a rare contact factor deficiency that can markedly prolong the activated partial thromboplastin time (aPTT) without a bleeding phenotype. Because viscoelastic hemostatic assays also rely on contact activation, their behavior in severe PK deficiency is relevant to perioperative evaluation of isolated ...
Jeremy W. Jacobs, Anton Matafonov, Patricia G. Baxter, Qiufang Cheng, Garrett S. Booth, Deva Sharma, Benjamin F. Tillman, David Gailani   +7 more
wiley   +1 more source

T-kininogen inhibits kinin-mediated activation of ERK in endothelial cells

Biological Research, 2002
Serum levels of T-kininogen increase dramatically as rats approach the end of their lifespan. Stable expression of the protein in Balb/c 3T3 fibroblasts leads to a dramatic inhibition of cell proliferation, as well as inhibition of the ERK signaling ...
ELIAS LEIVA-SALCEDO, VIVIANA PEREZ, CLAUDIO ACUÑA-CASTILLO, ROBIN WALTER, FELIPE SIERRA   +4 more
doaj  

Evidence for the presence of a kininogen-like species in a case of total deficiency of low and high molecular weight kininogens

Brazilian Journal of Medical and Biological Research, 1998
Low and high molecular weight kininogens (LK and HK), containing 409 and 626 amino acids with masses of ~65 and 120 kDa after glycosylation, respectively, are coded by a single gene mapped to the human chromosome 3 by alternative splicing of the ...
D. Veloso
doaj   +1 more source

A novel detection method of cleaved plasma high‐molecular‐weight kininogen reveals its correlation with Alzheimer's pathology and cognitive impairment

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018
Introduction Accumulation of β‐amyloid is a pathological hallmark of Alzheimer's disease (AD). β‐Amyloid activates the plasma contact system leading to kallikrein‐mediated cleavage of intact high‐molecular‐weight kininogen (HKi) to cleaved high‐molecular‐
Hitomi Yamamoto‐Imoto, Daria Zamolodchikov, Zu‐Lin Chen, S. Lloyd Bourne, Syeda Rizvi, Pradeep Singh, Erin H. Norris, Frances Weis‐Garcia, Sidney Strickland   +8 more
doaj   +1 more source

Tunable Fabrication of 2D‐Layered Magnesium Nanosilicates With Hemostatic Properties

Small Science, Volume 6, Issue 9, September 2026.
Tunable 2D magnesium nanosilicates form bioactive protein coronas, support cellular internalization, and promote hemostatic activity. These nanoclays enable shear‐thinning gel formation and reduce clotting time and blood loss, highlighting their potential for wound‐management applications. Tunable fabrication of inorganic two‐dimensional (2D) nanoclays
Anna L. Keller, Kanwar Abhay Singh, Saptarshi Biswas, Kavita Kadu, Sarah E. Miller, Weijian Hua, Sridevi Conjeevaram, Vaaridhi Ramanuja, Shounak Roy, Samantha Foster, Changwoo Do, Wei‐Ren Chen, Yifei Jin, Akhilesh K. Gaharwar   +13 more
wiley   +1 more source

Preliminary Evaluation of a Novel Lupus Anticoagulant Activity Assay Unaffected by Anticoagulants

Journal of Clinical Laboratory Analysis, Volume 40, Issue 15, August 2026.
A novel one‐step lupus anticoagulant (LA) assay based on the LA‐sensitivity ratio (LA‐SR) was developed to simplify diagnostic testing and reduce potential interference from anticoagulants. The LA‐SR method showed good agreement with guideline‐based LA testing (dRVVT and/or LA‐sensitive APTT) for the detection of LA and demonstrated limited influence ...
Ayu Hidaka, Risa Kaneshige, Seika Nakamura, Yukari Motoki, Junzo Nojima   +4 more
wiley   +1 more source

Roles for the Kallikrein-Kinin System in Inflammatory Exudation and Pain: Lessons From Studies on Kininogen-Deficient Rats

Journal of Pharmacological Sciences, 2003
: Roles for the kallikrein-kinin system in inflammation have been investigated extensively, and many reviews on this topic have been published during the 50 years since the discovery of bradykinin in 1949. Recent progress in the field has been remarkable
Akinori Ueno, Sachiko Oh-ishi
doaj   +1 more source

Factor XI Inhibition for Ischemic Stroke Secondary Prevention: Pharmacology, Clinical Evidence, and Future Directions

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Ischemic stroke remains a leading cause of death and disability worldwide, and bleeding (particularly intracranial hemorrhage) continues to limit conventional antithrombotic therapy in secondary prevention, even with direct oral anticoagulants.
Federica Ferrari, Roberto Federico Villa
wiley   +1 more source