Results 21 to 30 of about 17,108 (133)
Towards understanding the kallikrein-kinin system: insights from measurement of kinin peptides
Brazilian Journal of Medical and Biological Research, 2000 The kallikrein-kinin system is complex, with several bioactive peptides that are formed in many different compartments. Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium ...
D.J. Campbell
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Serum bridging molecules drive candidal invasion of human but not mouse endothelial cells.
PLoS Pathogens, 2022 During hematogenously disseminated candidiasis, blood borne fungi must invade the endothelial cells that line the blood vessels to infect the deep tissues.
Quynh T Phan +9 more
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Maternal serum proteomic profiles of pregnant women with type 1 diabetes
Scientific Reports, 2022 Despite improvement in the care of diabetes over the years, pregnancy complicated by type 1 diabetes (T1DM) is still associated with adverse maternal and neonatal outcomes.
Paweł Gutaj +9 more
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Assembly of Bioactive Superstructures via Metal–Phenolic Complexation for Blood Purification
Angewandte Chemie, Volume 138, Issue 40, 28 September 2026.Bioactive superstructures are assembled via metal–phenolic‐mediated assembly on agarose templates, followed by modification with human serum albumin. These superstructures demonstrate high bilirubin adsorption efficiency, strong antibacterial activity, and anticoagulant activity, providing a strategy for the rational design of multifunctional blood ...
Po Wang +12 more
wiley +2 more sources
Drugs of the Kallikrein–Kinin System: An Overview
Drugs and Drug Candidates, 2023 The kallikrein–kinin system consists of the two kininogen substrates present in the blood plasma, and two serine proteases: the plasma and tissue kallikreins.
François Marceau
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Kininogen Cleavage Assay: Diagnostic Assistance for Kinin-Mediated Angioedema Conditions. [PDF]
PLoS ONE, 2016 Angioedema without wheals (AE) is a symptom characterised by localised episodes of oedema presumably caused by kinin release from kininogen cleavage. It can result from a hereditary deficiency in C1 Inhibitor (C1Inh), but it can present with normal level
Rémi Baroso +7 more
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Mutant plasminogen in hereditary angioedema is bypassing FXII/kallikrein to generate bradykinin
Frontiers in Physiology, 2023 Hereditary angioedema (HAE) is characterized by recurrent localized edema in various organs, which can be potentially fatal. There are different types of hereditary angioedema, which include genetic deficiency of C1 inhibitor (C1-INH) and hereditary ...
Stefan Hintze +12 more
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Stem Cells International, 2019 Background/Objectives. Carbonic anhydrase 1 (CA1)/kininogen and selenoprotein W (SelW)/14-3-3η signal transduction orchestrate oxidative stress, which can also be regulated by nitric oxide (NO).
Wan-cheng Yu +6 more
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Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles
Mass Spectrometry Reviews, EarlyView.ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág +5 more
wiley +1 more source
Plasma Prekallikrein: Its Role in Hereditary Angioedema and Health and Disease
Frontiers in Medicine, 2018 Plasma prekallikrein (PK) has a critical role in acute attacks of hereditary angioedema (HAE). Unlike C1 inhibitor, its levels fall during HAE attacks with resultant cleaved high-molecular-weight kininogen.
Alvin H. Schmaier
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