A brief comparison of human factor XII-Ala188 and factor XII-Pro188 [PDF]
Research and Practice in Thrombosis and HaemostasisAleksandr Shamanaev, David Gailani
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Cardiopulmonary bypass in a pediatric patient with factor XII deficiency [PDF]
The Journal of ExtraCorporeal TechnologyThe safe use of cardiopulmonary bypass (CPB) relies upon the ability to administer, monitor, and reverse anticoagulation. Although rare, the factor XII deficient patient creates a challenge for the perfusionist due to resultant complications in ...
Fenske Julie M. +2 more
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Homozygous missense variant F12 (Gly506Asp) associated with severe factor XII deficiency: a case report [PDF]
Journal of Medical Case Reports, 2023 Background Factor XII deficiency can be related to either homozygous or compound heterozygous pathogenic variants in the F12 gene. The disease is commonly known as Hageman trait and is inherited in both autosomal recessive or dominant patterns ...
Mansour Aljabry +5 more
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Coagulation factor XII haploinsufficiency is protective against venous thromboembolism in a population-scale multidimensional analysis [PDF]
Nature CommunicationsCoagulation factor XII has been identified as a potential drug target that could prevent thrombosis without increasing the risk of bleeding. However, human data to support the development of factor XII-directed therapeutics are lacking.
Amelia K. Haj +20 more
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Hereditary factor XII deficiency in an adult patient: A case report [PDF]
SAGE Open Medical Case Reports, 2022 Factor XII deficiency is a rare autosomal recessive health condition usually discovered incidentally during routine coagulation screening before surgery after investigating a prolongation of the activated partial thromboplastin time.
Rehab Y Al-Ansari +3 more
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Congenital hemophilia A with low activity of factor XII: a case report and literature review [PDF]
Italian Journal of Pediatrics, 2021 Background Congenital hemophilia A is a recessive inherited hemorrhagic disorder. According to the activity of functional coagulation factors, the severity of hemophilia A is divided into three levels: mild, moderate and severe.
Baoyu Lei, Chuang Liang, Haiyan Feng
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An unanticipated prolonged baseline ACT during cardiac surgery due to factor XII deficiency [PDF]
Annals of Cardiac Anaesthesia, 2022 Factor XII (FXII) deficiency is a congenital disorder inherited as an autosomal recessive condition. In his heterozygous form, it is relatively common in the general population.
Heleen J.C L. Apostel +3 more
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Roles of Factor XII in Innate Immunity [PDF]
Frontiers in Immunology, 2019 Factor XII (FXII) is the zymogen of serine protease, factor XIIa (FXIIa). FXIIa enzymatic activities have been extensively studied and FXIIa inhibition is emerging as a promising target to treat or prevent thrombosis without creating a hemostatic defect.
Thomas Renné +2 more
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Factor XII–driven coagulation traps bacterial infections [PDF]
Journal of Experimental MedicineLynn Butler +2 more
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Phenotypic and genetic analyses of four cases of coagulation factor XII deficiency
Hematology, 2022 Objectives To identify the clinical phenotypic and molecular pathogeneses of four cases of coagulation factor XII deficiency and to deepen the cognition of this disease.Methods Coagulation tests were performed through one stage of coagulation on a STAGO ...
Shanshan Li +7 more
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