Results 1 to 10 of about 15,476,183 (237)

Roles of Factor XII in Innate Immunity [PDF]

Frontiers in Immunology, 2019
Factor XII (FXII) is the zymogen of serine protease, factor XIIa (FXIIa). FXIIa enzymatic activities have been extensively studied and FXIIa inhibition is emerging as a promising target to treat or prevent thrombosis without creating a hemostatic defect.
Thomas Renné, Evi X. Stavrou, Evi X. Stavrou   +2 more
doaj   +6 more sources

Factor XII–driven coagulation traps bacterial infections [PDF]

Journal of Experimental Medicine
Factor XII drives thrombosis but is dispensable for hemostasis, making it an anticoagulant drug target. This study shows that factor XII–triggered coagulation traps pathogens and limits bacterial dissemination, highlighting a role of prothrombotic ...
Sandra Konrath, Katrin F Nickel, Lynn M Butler   +2 more
exaly   +3 more sources

A brief comparison of human factor XII-Ala188 and factor XII-Pro188 [PDF]

Research and Practice in Thrombosis and Haemostasis
Aleksandr Shamanaev, David Gailani
doaj   +4 more sources

Factor XII Structure-Function Relationships. [PDF]

Semin Thromb Hemost, 2023
Factor XII (FXII), the zymogen of the protease FXIIa, contributes to pathologic processes such as bradykinin-dependent angioedema and thrombosis through its capacity to convert the homologs prekallikrein and factor XI to the proteases plasma kallikrein ...
Shamanaev A, Litvak M, Ivanov I, Srivastava P, Sun MF, Dickeson SK, Kumar S, He TZ, Gailani D.   +8 more
europepmc   +2 more sources

Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains. [PDF]

Blood Adv, 2022
Key Points The FXII EGF1 domain promotes surface binding, FXII activation on surfaces, and FXIIa activation of prekallikrein on surfaces. The FXII FN2 and KNG domains are part of a mechanism that restricts FXII activation in the absence of a surface.
Shamanaev A, Ivanov I, Sun MF, Litvak M, Srivastava P, Mohammed BM, Shaban R, Maddur A, Verhamme IM, McCarty OJT, Law RHP, Gailani D.   +11 more
europepmc   +2 more sources

Identification of the factor XII contact activation site enables sensitive coagulation diagnostics. [PDF]

Nat Commun, 2021
Contact activation refers to the process of surface-induced activation of factor XII (FXII), which initiates blood coagulation and is captured by the activated partial thromboplastin time (aPTT) assay.
Heestermans M, Naudin C, Mailer RK, Konrath S, Klaetschke K, Jämsä A, Frye M, Deppermann C, Pula G, Kuta P, Friese MA, Gelderblom M, Sickmann A, Preston RJS, Nofer JR, Rose-John S, Butler LM, Salomon O, Stavrou EX, Renné T.   +19 more
europepmc   +2 more sources

Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease.

Blood, 2023
A hypercoagulable state, chronic inflammation, and increased risk of venous thrombosis and stroke are prominent features in patients with sickle cell disease (SCD).
Sparkenbaugh EM, Henderson MW, Miller-Awe M, Abrams C, Ilich A, Trebak F, Ramadas N, Vital S, Bohinc D, Bane KL, Chen C, Patel M, Wallisch M, Renné T, Gruber A, Cooley B, Gailani D, Kasztan M, Vercellotti GM, Belcher JD, Gavins FE, Stavrou EX, Key NS, Pawlinski R.   +23 more
europepmc   +2 more sources

Antithrombotic coating with sheltered positive charges prevents contact activation by controlling factor XII-biointerface binding. [PDF]

Nat Mater
Antithrombotic surfaces that prevent coagulation activation without interfering with haemostasis are required for blood-contacting devices. Such materials would restrain device-induced thrombogenesis and decrease the need for anticoagulant use, thereby ...
Ji H, Yu K, Abbina S, Xu L, Xu T, Cheng S, Vappala S, Arefi SMA, Rana MM, Chafeeva I, Drayton M, Gonzalez K, Liu Y, Grecov D, Conway EM, Zhao W, Zhao C, Kizhakkedathu JN.   +17 more
europepmc   +2 more sources

Single-chain factor XII: a new form of activated factor XII [PDF]

Current Opinion in Hematology, 2017
Purpose of review Exposure of blood to foreign surfaces induces reciprocal conversion of the plasma proteins factor XII (fXII) and plasma prekallikrein (PPK) to the proteases α-fXIIa and α-kallikrein. This process, called contact activation, has a range of effects on host defence mechanisms, including promoting coagulation. The
Ivan, Ivanov, Anton, Matafonov, David, Gailani   +2 more
openaire   +3 more sources

Homozygous missense variant F12 (Gly506Asp) associated with severe factor XII deficiency: a case report [PDF]

Journal of Medical Case Reports, 2023
Background Factor XII deficiency can be related to either homozygous or compound heterozygous pathogenic variants in the F12 gene. The disease is commonly known as Hageman trait and is inherited in both autosomal recessive or dominant patterns ...
Mansour Aljabry, Aljoud Algazlan, Nouf Alsubaie, Shatha Bin Dher, Hassan Semar Aljabri, Ghazi S. Alotaibi   +5 more
doaj   +2 more sources