Results 31 to 40 of about 15,476,282 (336)
Mechanism and therapy of hereditary angioedema typ III and role of the contact system in inflammatory diseases [PDF]
, 2014 Combinations of proinflammatory and procoagulant reactions are associated with a variety of disorders affecting the cardiovascular system. Vascular leakage contributes to the pathology of conditions such as, sepsis, allergy and anaphylactic reactions ...
Björkqvist, Jenny
core +1 more source
The new era of anticoagulation: factor XI and XII inhibitors
Bleeding, Thrombosis and Vascular Biology, 2023 The two last decades have witnessed a revolution in the field of anticoagulation, mainly due to the advent of direct anticoagulant with targeted action against single coagulation proteins. However, the residual risk of cardio- and cerebrovascular events,
Domenico Prisco +3 more
doaj +1 more source
Science-Business eXchange, 2014 Researchers have found that inhibiting either factor XII or factor XI can provide thromboprotection without increasing the risk of bleeding. Both targets could eliminate the main drawback of existing anticoagulants.
openaire +1 more source
Mechanisms and regulation of the polyphosphate/factor XII-driven contact system in thrombosis and hemostasis [PDF]
, 2016 Blood coagulation leading to fibrin formation is essential to prevent loss of blood (hemostasis), but can also contribute to occlusion of vessels (thrombosis).
Labberton, Linda
core +1 more source
Journal of Medical Case Reports, 2020 Background This case report presents a case of a patient with global cerebral infarction of uncertain etiology following an emergency surgery for acute type A aortic dissection. As a result, factor XII deficiency was revealed postoperatively.
Keisuke Yoshida +5 more
doaj +1 more source
Factor XII (Hageman) Levels in Women with Recurrent Pregnancy Loss
Journal of Pregnancy, 2014 Objective. To evaluate factor XII levels in women with recurrent pregnancy loss (RPL) in a tertiary referral hospital. Methods. Women who were referred to our hospital for two consecutive abortions or three abortions in between 2007 and 2013 were ...
A. Seval Ozgu-Erdinc +5 more
doaj +1 more source
TH Open, 2019 The contributions of coagulation factor XI (FXI) and FXII to human clot formation is not fully known. Patients with deficiency in FXI have a variable mild bleeding risk, whereas FXII deficiency is not associated with bleeding.
José W. P. Govers-Riemslag +7 more
doaj +1 more source
Factor XII/XIIa inhibitors: Their discovery, development, and potential indications.
European journal of medicinal chemistry, 2020 Coagulation factor XII (FXII), a S1A serine protease, was discovered more than fifty years ago. However, its in vivo functions and its three-dimensional structure started to be disclosed in the last decade.
C. Davoine +3 more
semanticscholar +1 more source
The contact system proteases play disparate roles in streptococcal sepsis
Haematologica, 2020 Sepsis causes an activation of the human contact system, an inflammatory response mechanism against foreign surfaces, proteins and pathogens. The serine proteases of the contact system, factor XII and plasma kallikrein, are decreased in plasma of septic ...
Juliane Köhler +9 more
doaj +1 more source
Coagulation factor XII contributes to hemostasis when activated by soil in wounds.
Blood Advances, 2020 Bleeding is a common contributor to death and morbidity in animals and provides strong selective pressure for the coagulation system to optimize hemostasis for diverse environments.
L. J. Juang +7 more
semanticscholar +1 more source